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Chinese Journal of Polymer Science

, Volume 36, Issue 10, pp 1139–1149 | Cite as

Multifunctional Nanoplatform Based on pH-responsive Micelle Coated with Discontinuous Gold Shell for Cancer Photothermo-chemotherapy and Photoacoustic Tomography

  • Yi Huang
  • Xiao-Xia Li
  • Lu Zhang
  • Xiao-Yan Chen
  • Cheng-Bo Liu
  • Jing-Qin Chen
  • Yong WangEmail author
  • Xin-Tao Shuai
Article
  • 81 Downloads

Abstract

Photothermo-chemotherapy, as a new strategy for cancer treatment, incorporates the complementary advantages of photothermal therapy and chemotherapy. In this study, a pH-sensitive diblock copolymer poly(aspartic acid-butanediamine)-poly(2-(diisopropylamino)ethyl methacrylate) (PAsp(DAB)-PDPA) was synthesized and self-assembled into doxorubicin-loaded micelle, which was further used as a template to form a gold nanoshell. After further modification with poly(ethylene glycol), the resulting nanoplatform provided good biocompatibility and desirable photo-thermal conversion efficiency to facilitate photothermal therapy. Meanwhile the nanoparticle also exhibited pH sensitivity, which prevented drug loss while circulating in the blood but enabled rapid drug release after endocytosis. An improved effect was achieved with the combination of photothermal therapy and chemotherapy. In addition, systemic delivery of the nanoplatform could be monitored by photoacoustic tomography. Thereby, this multifunctional nanoplatform would be highly potential for the diagnosis and therapy of cancer.

Keywords

Gold nanoshell Photoacoustic tomography Photothermo-chemotherapy pH-sensitive micelle 

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Notes

Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (No. U1401242), National Basic Research Program of China (No. 2015CB755500), Natural Science Foundation of the Guangdong Province (No. 2014A030312018) and the Fundamental Research Funds for the Central Universities (Nos. 17lgjc01 and 17lgpy08).

Supplementary material

10118_2018_2141_MOESM1_ESM.pdf (278 kb)
Multifunctional Nanoplatform Based on pH-responsive Micelle Coated with Discontinuous Gold Shell for Cancer Photothermo-Chemotherapy and Photoacoustic Tomography

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Copyright information

© Chinese Chemical Society, Institute of Chemistry, Chinese Academy of Sciences and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Yi Huang
    • 1
  • Xiao-Xia Li
    • 1
  • Lu Zhang
    • 1
  • Xiao-Yan Chen
    • 1
  • Cheng-Bo Liu
    • 2
  • Jing-Qin Chen
    • 2
  • Yong Wang
    • 1
    Email author
  • Xin-Tao Shuai
    • 1
  1. 1.PCFM Lab of Ministry of Education, School of Materials Science and EngineeringSun Yat-Sen UniversityGuangzhouChina
  2. 2.Research Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina

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