Chinese Journal of Polymer Science

, Volume 36, Issue 5, pp 604–611 | Cite as

Comparative Studies on Hydrophilic and Hydrophobic Segments Grafted Poly(vinyl chloride)

  • Yan Zhang
  • Zi-Peng Yuan
  • Yu Qin
  • Ji Dai
  • Tao Zhang


Poly(vinyl chloride) (PVC) is one of the mostly produced plastics in the world and is widely used in single-use medical devices. However, the additives that are often necessary for PVC arouse concerns of its safety, thus quests the modifications of PVC itself. In this study, poly(ethylene glycol) (PEG) and polydimethylsiloxane (PDMS) segments were grafted onto PVC backbone in similar ways, and the chemical structures of the modified PVCs were characterized by Fourier transform infrared spectra, X-ray photoelectron spectra, thermogravimetric analysis and differential scanning calorimetry. Moreover, the water contact angle, protein adsorption, platelet adhesion, cell attachment and proliferation on different material surfaces were studied and compared. It was found that both PEG and PDMS grafting yielded improvement on biocompatibility compared with bare PVC, while hydrophobic PDMS grafted PVC showed more effective on cell attachment and proliferation than that of hydrophilic PEG grafted PVC.


Poly(vinyl chloride) Poly(ethylene glycol) Polydimethylsiloxane Grafting Biomedical properties 


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This work was financially supported by the National Natural Science Foundation of China (No. 81671792), National Key R&D program of China (No. 2016YFC0104100), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).


  1. 1.
    Allsopp, M. W.; Vianello, G., “Poly(vinyl chloride)” in “Ullmann’s encyclopedia of industrial chemistry, 7th Ed.”; ed. by Elvers, B., John Wiley & Sons, New York, 2014.Google Scholar
  2. 2.
    Blass, C. R., in “The role of poly(vinyl chloride) in healthcare”; Rapra Technology Limited, Shrewsbury, UK, 2001.Google Scholar
  3. 3.
    PVCMed Alliance, in “PVC medical devices”,, available on Feb. 11, 2017.Google Scholar
  4. 4.
    Lakshmi, S.; Jayakrishnan, A. Migration resistant, bloodcompatible plasticized polyvinyl chloride for medical and related applications. Artif. Organs 1998, 22(3), 222–229.CrossRefGoogle Scholar
  5. 5.
    Scientific Committee on Emerging and Newly-Identified Health Risks (SCENIHR), Scientific opinion on the safety of medical devices containing DEHP-plasticized PVC or other plasticizers on neonates and other groups possibly at risk. European Commission, Brussels, 2008.Google Scholar
  6. 6.
    Ferruti, P.; Barbucci, R.; Danzo, N.; Torrisi, A.; Puglisi, O.; Pignataro, S.; Spartano, P. Preparation and ESCA characterization of poly(vinyl chloride) surface-grafted with heparin-complexing poly(amido-amine) chains. Biomaterials 1982, 3(1), 33–37.CrossRefGoogle Scholar
  7. 7.
    Singh, J.; Ray, A. R.; Singhal, J. P.; Singh, H. Radiation-induced graft copolymerization of methacrylic acid on to poly(vinyl chloride) films and their thrombogenicity. Biomaterials 1990, 11(7), 473–476.CrossRefGoogle Scholar
  8. 8.
    Ji, J.; Feng, L.; Shen, J.; Barbosa, M. A. Preparation of albumin preferential surfaces on poly(vinyl chloride) membranes via surface self-segregation. J. Biomed. Mater. Res. 2002, 61(2), 252–295.CrossRefGoogle Scholar
  9. 9.
    Balakrishnan, B.; Kumar, D. S.; Yoshida, Y.; Jayakrishnan, A. Chemical modification of poly(vinyl chloride) resin using poly(ethylene glycol) to improve blood compatibility. Biomaterials 2005, 26(17), 3495–3502.CrossRefGoogle Scholar
  10. 10.
    Asadinezhad, A.; Novak, I.; Lehocky, M.; Bilek, F.; Vesel, A.; Junkar, I.; Saha, P.; Popelka, A. Polysaccharides coatings on medical-grade PVC: a probe into surface characteristics and the extent of bacterial adhesion. Molecules 2010, 15(2), 1007–1027.CrossRefGoogle Scholar
  11. 11.
    Bigot, S.; Louarn, G.; Kebir, N.; Burel, F. Click grafting of seaweed polysaccharides onto PVC surfaces using an ionic liquid as solvent and catalyst. Carbohyd. Polym. 2013, 98(2), 1644–1649.CrossRefGoogle Scholar
  12. 12.
    Neffe, A. T.; von Ruesten-Lange, M.; Braune, S.; Luetzow, K.; Roch, T.; Richau, K.; Jung, F.; Lendlein, A. Poly(ethylene glycol) grafting to poly(ether imide) membranes: influence on protein adsorption and thrombocyte adhesion. Macromol. Biosci. 2013, 13(12), 1720–1729.CrossRefGoogle Scholar
  13. 13.
    Patel, R.; Patel, M.; Ahn, S. H.; Sung, Y. K.; Lee, H. K.; Kim, J. H.; Sung, J. S. Bioinert membranes prepared from amphiphilic poly(vinyl chloride)-g-poly(oxyethylene methacrylate) graft copolymers. Mat. Sci. Eng. Mater. 2013, 33(3), 1662–1670.CrossRefGoogle Scholar
  14. 14.
    Dabagh, M.; Abdekhodaie, M. J.; Khorasani, M. T. Effects of polydimethylsiloxane grafting on the calcification, physical properties, and biocompatibility of polyurethane in a heart valve. J. Appl. Polym. Sci. 2005, 98(2), 758–766.CrossRefGoogle Scholar
  15. 15.
    Lakshmi, S.; Jayakrishnan, A. Synthesis, surface properties and performance of thiosulphate-substituted plasticized poly(vinyl chloride). Biomaterials 2002, 23(24), 4855–4862.CrossRefGoogle Scholar
  16. 16.
    Kainthan, R. K.; Gnanamani, M.; Ganguli, M.; Ghosh, T.; Brooks, D. E.; Maiti, S.; Kizhakkedathu, J. N. Blood compatibility of novel water soluble hyperbranched polyglycerol-based multivalent cationic polymers and their interaction with DNA. Biomaterials 2006, 27(31), 5377–5390.CrossRefGoogle Scholar
  17. 17.
    Gorbet, M. B.; Sefton, M. V. Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes. Biomaterials 2004, 25(26), 5681–5703.CrossRefGoogle Scholar

Copyright information

© Chinese Chemical Society, Institute of Chemistry, Chinese Academy of Sciences and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Yan Zhang
    • 1
  • Zi-Peng Yuan
    • 1
  • Yu Qin
    • 1
  • Ji Dai
    • 1
  • Tao Zhang
    • 1
  1. 1.Department of Biomedical Engineering, College of Engineering and Applied SciencesNanjing UniversityNanjingChina

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