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DNA hydrogels formed of bended DNA scaffolds and properties study

Chinese Journal of Polymer Science volume 35, pages 1307–1314 (2017)Cite this article

Abstract

In recent years, DNA supramolecular hydrogels have attracted much attention due to their injectability, biocompatibility, responsiveness and self-healing properties. In this work, we designed a linear DNA brick containing one duplex with two cytosine (C)-rich sequence on both ends. This brick can first assemble to form duplex under pH 8 condition. After adjusting the pH to 5, the C-rich sequence tends to form intermolecular i-motif structure, which joins the linear DNA molecules together to form interlocked cyclic structures and yield the DNA hydrogel. By adjusting the length and bending curvature of the duplex part of the molecule, one can change the basic unit of the hydrogel structure to tune the properties of the DNA hydrogel.

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Authors and Affiliations

  1. Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China

    Hao-yang Jia, Jie-zhong Shi, Yu Shao & Dong-sheng Liu  (刘冬生)

Authors
  1. Hao-yang Jia
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  2. Jie-zhong Shi
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  3. Yu Shao
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  4. Dong-sheng Liu  (刘冬生)
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Corresponding author

Correspondence to Dong-sheng Liu  (刘冬生).

Additional information

This work was financially supported by the National Basic Research Program of China (973 program, No. 2013CB932803), the National Natural Science Foundation of China (No. 21534007) and the Beijing Municipal Science & Technology Commission.

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Jia, Hy., Shi, Jz., Shao, Y. et al. DNA hydrogels formed of bended DNA scaffolds and properties study. Chin J Polym Sci 35, 1307–1314 (2017). https://doi.org/10.1007/s10118-017-1978-6

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  • DOI: https://doi.org/10.1007/s10118-017-1978-6

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