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Chinese Journal of Polymer Science

, Volume 35, Issue 6, pp 693–699 | Cite as

Poly(β-cyclodextrin)-mediated polylactide-cholesterol stereocomplex micelles for controlled drug delivery

Rapid Communication

Abstract

A series of host-guest interaction-adjusted polylactide stereocomplex micelles was prepared via the self-assembly of 4-armed poly(ethylene glycol)-block-poly(L-lactide/D-lactide)-cholesterol (4-armed PEG-b-PLLA/PDLA-CHOL) and poly(β-cyclodextrin) (PCD) with the molar ratios of CHOL/β-CD at 1:0.5, 1:1, and 1:2 in an aqueous environment. The hydrodynamic diameters of the micelles ranged from 84.1 nm to 107 nm depending on the molar ratio of CHOL/β-CD. It was shown that the micelle with the largest proportion of PCD possessed excellent abilities in drug release, cell internalization as well as proliferation inhibitory effect toward human A549 lung cancer cells. The results demonstrated that the stereocomplex and host-guest interactions-mediated PLA micelles exhibited great potential in sustained drug delivery.

Keywords

Polylactide Stereocomplex micelle Poly(β-cyclodextrin) Host-guest interaction Controlled drug delivery 

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Supplementary material

10118_2017_1932_MOESM1_ESM.pdf (413 kb)
Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery

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Copyright information

© Chinese Chemical Society, Institute of Chemistry, Chinese Academy of Sciences and Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunChina
  2. 2.Institute of Molecular Sciences, CNRS, Université Paris-SudUniversité Paris SaclayOrsayFrance

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