A method to accelerate the gelation of disulfide-crosslinked hydrogels


A glutathione-disulfide-ended poly(ethylene glycol) (GSSG-PEG-GSSG) was designed. It is a much more efficient accelerator than glutathione disulfide (GSSG) for the gelation of an 8arm-PEG-SH polymer solution, and the gelation time can be tuned from hours to minutes at the physiological pH and temperature. A mechanism was proposed to explain the different behaviors of the GSSG and GSSG-PEG-GSSG gelation systems. Due to the ever-going thiol-disulfide exchange reaction, the thiol-disulfide hydrogels also showed interesting swelling behavior.

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Corresponding authors

Correspondence to Xinming Tong 童新明 or Yanbin Huang 黄延宾.

Additional information

This work was financially supported by the National Natural Science Foundation of China (No. 21004038).

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Yan, X., Yang, X., Tong, X. et al. A method to accelerate the gelation of disulfide-crosslinked hydrogels. Chin J Polym Sci 33, 118–127 (2015). https://doi.org/10.1007/s10118-015-1567-5

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  • Thiol-disulfide exchange
  • In situ gelation
  • Glutathione
  • PEG