Chinese Journal of Polymer Science

, Volume 33, Issue 1, pp 118–127 | Cite as

A method to accelerate the gelation of disulfide-crosslinked hydrogels

  • Xiaoshan Yan
  • Xiaotong Yang
  • Xinming Tong (童新明)Email author
  • Yanbin Huang (黄延宾)Email author


A glutathione-disulfide-ended poly(ethylene glycol) (GSSG-PEG-GSSG) was designed. It is a much more efficient accelerator than glutathione disulfide (GSSG) for the gelation of an 8arm-PEG-SH polymer solution, and the gelation time can be tuned from hours to minutes at the physiological pH and temperature. A mechanism was proposed to explain the different behaviors of the GSSG and GSSG-PEG-GSSG gelation systems. Due to the ever-going thiol-disulfide exchange reaction, the thiol-disulfide hydrogels also showed interesting swelling behavior.


Thiol-disulfide exchange In situ gelation Glutathione PEG 


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Copyright information

© Chinese Chemical Society, Institute of Chemistry, Chinese Academy of Sciences and Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Key Laboratory of Advanced Materials (MOE), Department of Chemical EngineeringTsinghua UniversityBeijingChina

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