Skip to main content
SpringerLink
Log in

Release of ibuprofen from PEG-PLLA electrospun fibers containing poly(ethylene glycol)-b-poly(α-hydroxy octanoic acid) as an additive

  • Published:
Chinese Journal of Polymer Science Aims and scope Submit manuscript

Abstract

Poly(α-hydroxy octanoic acid) was first used as an additive for the preparation of electrospun ultra-fine fibers of poly(ethylene glycol)-b-poly(L-lactide) (PEG-PLLA). Ibuprofen was loaded in the electrospun ultra-fine fibers. The results from environmental scanning electron microscopy (ESEM), wide angle X-ray diffraction (WAXD) and differential scanning calorimetry (DSC) demonstrated that ibuprofen could be perfectly entrapped in the fibers electrospun from PEG-PLLA using α-hydroxy octanoic acid or PEG-b-poly(α-hydroxy octanoic acid) (PEG-PHOA) as additives. Compared with electrospun PEG-PLLA fibers which entrapped 20 wt% ibuprofen, the PEG-PLLA electrospun fibers containing PEG-PHOA exhibited integral and robust after 1 week incubated in 37°C, pH 7.4 phosphate buffer solution with 10 μg/mL proteinase K. Compared with electrospun fibers without PEG-PHOA, the concentration of proteinase K in release media had less effect on the release rate of ibuprofen. An unique release profile was found from PEG-PLLA fiber after the incorporation of PEG-PHOA. Enzyme degradation experiments demonstrated that PEG-PHOA but not α-hydroxy octanoic acid monomer was the crucial factor for integrity maintenance of the electrospun fibers, which may be due to the enzyme degradation tolerance property of the PEG-PHOA polymer additive.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Biondi, M., Ungaro, F., Quaglia, F. and Netti, P.A., Adv. Drug Deliv. Rev., 2008, 60: 229

    Article  CAS  Google Scholar 

  2. Vasir, J.K. and Labhasetwar, V., Adv. Drug Deliv. Rev., 2007, 59: 718

    Article  CAS  Google Scholar 

  3. Kretlow, J.D., Klouda, L. and Mikos, A.G., Adv. Drug Deliv. Rev., 2007, 59: 263

    Article  CAS  Google Scholar 

  4. Saito, N., Murakami, N., Takahashi, J., Horiuchi, H., Ota, H., Kato, H., Okada, T., Nozaki, K. and Takaoka, K., Adv. Drug Deliv. Rev., 2005, 57: 1037

    Article  CAS  Google Scholar 

  5. Jilek, S., Merkle, H.P. and Walter, E., Adv. Drug Deliv. Rev., 2005, 57: 377

    Article  CAS  Google Scholar 

  6. Cerral, P., Tricoli, M., Lelli, L. and Guerra, G.D., J. Mater. Sci. Mater. Med., 1994, 5: 308

    Article  Google Scholar 

  7. Kissel, T., Li, Y. and Unger, F., Adv. Drug Deliv. Rev., 2002, 54: 99

    Article  CAS  Google Scholar 

  8. Anderson, J.M. and Shive, M.S., Adv. Drug Deliv. Rev., 1997, 28: 5

    Article  CAS  Google Scholar 

  9. Yasukawa, T., Kimura, H., Tabata, Y. and Ogura, Y., Adv. Drug Deliv. Rev., 2001, 52: 25

    Article  CAS  Google Scholar 

  10. Vila, A., Gill, H., McCallion, O. and Alonso, M.J., J. Control. Release, 2004, 98: 231

    Article  CAS  Google Scholar 

  11. Hayashi, T., Prog. Polym. Sci., 1994, 19(4): 663

    Article  CAS  Google Scholar 

  12. Blanco, E., Bey, E.A., Dong, Y., Weinberg, B.D., Sutton, D.M., Boothman, D.A. and Gao, J.M., J. Control. Release, 2007, 122: 365

    Article  CAS  Google Scholar 

  13. Choi, K.S. and Kim, D.J., J. Appl. Polym. Sci., 2002, 83: 435

    Article  CAS  Google Scholar 

  14. Xiong, X.Y., Li, Y.P., Li, Z.L., Zhou, C.L., Tam, K.C., Liu, Z.Y. and Xie, G.X., J. Control. Release, 2007, 120: 11

    Article  CAS  Google Scholar 

  15. Xiong, X.Y., Tam, K.C. and Gan, L.H., J. Control. Release., 2005, 103: 73

    Article  CAS  Google Scholar 

  16. Kasperczyk, J., Jelonek, K., Dobrzyñski, P. and Jarz, B., J. Control. Release, 2006, 116: e5

    Article  CAS  Google Scholar 

  17. Urata, T., Arimori, K. and Nakano, M., J. Control. Release, 1999, 58: 133

    Article  CAS  Google Scholar 

  18. Ishihara, T., Izumo, N., Higaki, M., Shimada, E., Hagi, T., Mine, L., Ogawa, Y. and Mizushima, Y., J. Control. Release, 2005, 105: 68

    Article  CAS  Google Scholar 

  19. Gao, H., Yang, Y.W., Fan, Y.G. and Ma, J.B., J. Control. Release, 2006, 112: 301

    Article  CAS  Google Scholar 

  20. Lee, E.S., Oh, K.T., Kim, D., Youn, Y.S. and Bae, Y.H., J. Control. Release, 2007, 123: 19

    Article  CAS  Google Scholar 

  21. Xie, Z.G., Guan, H.L., Chen, X.S., Lv, C.H., Chen, L., Xu, X.L., Shi, Q. and Jing, X.B., J. Control. Release, 2007, 117(2): 210

    Article  CAS  Google Scholar 

  22. Trimaille, T., Möller, M. and Gurny, R., J. Polym. Sci. Part A: Polym. Chem., 2004, 42: 4379

    Article  CAS  Google Scholar 

  23. Kenawy, E.R., Bowlin, G.L., Mansfield, K., Layman, J., Simpson, D.G., Sanders, E.H. and Wnek, G.E., J. Control. Release, 2002, 81: 57

    Article  CAS  Google Scholar 

  24. Trimaille, T., Mondon, K., Gurny, R and Möller, M., Int. J. Pharm., 2006, 319: 147

    Article  CAS  Google Scholar 

  25. Zeng, J., Chen, X.S. and Jing, X.B., J. Appl. Polym. Sci., 2003, 89: 1085

    Article  CAS  Google Scholar 

  26. Zeng, J., Xu, X.Y., Chen, X.S., Liang, Q.Z., Bian, X.C., Yang, L.X. and Jing, X.B., J.Control. Release, 2003, 92: 227

    Article  CAS  Google Scholar 

  27. Zeng, J., Yang, L.X., Liang, Q.Z., Zhang, X.F., Guan, H.L., Xu, X.L., Chen, X.S. and Jing, X.B., J. Control. Release, 2005, 105: 43

    Article  CAS  Google Scholar 

  28. Lee, J.H., Go, A.K., Oh, S.H., Lee, K.E. and Yuk, S.H., Biomaterials, 2005, 26: 671

    Article  CAS  Google Scholar 

  29. Zhu, K.J., Xiangzhou, L. and Shilin, Y., J. Appl. Polym. Sci., 1990, 29: 1

    Article  Google Scholar 

  30. Wang, H., Deng, Y.J., Wang Y.L. and Zheng, H., Chinese Journal of Synthetic Chemistry, 2008, 16(1): 53

    Google Scholar 

  31. Kim, K., Luu, Y.K., Chang, C., Fang, D.F., Hsiao, B.S., Chu, B. and Hadjiargyrou, M., J. Control. Release, 2004, 98: 47

    Article  CAS  Google Scholar 

  32. Huang, Y.Y., Chung, T.W. and Tzeng, T.W., Int. J. Pharm., 1999, 182: 93

    Article  CAS  Google Scholar 

  33. Xu, X.L., Chen, X.S., Xu, X.Y., Lu, T.C., Wang, X., Yang, L.X. and Jing, X.B., J. Control. Release, 2006, 114: 307

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China

    Hao Wang & Ying-jie Deng  (邓英杰)

  2. School of Pharmaceutical Engineering, Pharmaceutical University, Shenyang, 110016, China

    Hong-rui Song

  3. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Hao Wang & Xue-si Chen  (陈学思)

Authors
  1. Hao Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hong-rui Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xue-si Chen  (陈学思)
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ying-jie Deng  (邓英杰)
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Xue-si Chen  (陈学思) or Ying-jie Deng  (邓英杰).

Additional information

This work was financially supported by the National Natural Science Foundation of China (Nos. 20274048, 50373043), the Chinese Academy of Sciences (No. KJCX2-SW-H07) and the “863 project” (No. 2002AA326100).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, H., Song, Hr., Chen, Xs. et al. Release of ibuprofen from PEG-PLLA electrospun fibers containing poly(ethylene glycol)-b-poly(α-hydroxy octanoic acid) as an additive. Chin J Polym Sci 28, 417–425 (2010). https://doi.org/10.1007/s10118-010-9041-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10118-010-9041-x

Keywords

Search

Navigation