Abstract
Acne is a long-lasting inflammatory skin condition that impacts the sebaceous units of the hair follicles, affecting around 85–90% of the population. Due to the potential for permanent facial scarring and negative social consequences, as well as the limitations of conventional medications like drug resistance and difficulties following treatment plans, it’s crucial to investigate non-pharmacological options for treating acne, among which radiofrequency(RF) shows distinct superiority. To assess the impact of RF in the management of acne vulgaris, we conducted a thorough examination of scientific literature (including clinical trials and scientific reviews) through electronic databases like MEDLINE and PubMed. Our analysis indicates that RF could be a viable substitute for acne treatment due to its notable effectiveness and minimal adverse effects.
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References
Sachdeva M, Tan J, Lim J et al (2021) The prevalence, risk factors, and psychosocial impacts of acne vulgaris in medical students: a literature review. Int J Dermatol 60:792–798. https://doi.org/10.1111/ijd.15280
Cruz S, Vecerek N, Elbuluk N (2023) Targeting inflammation in acne: current treatments and future prospects. Am J Clin Dermatol 24:681–694. https://doi.org/10.1007/s40257-023-00789-1
Rozas M, Hart de Ruijter A, Fabrega MJ et al (2021) From dysbiosis to healthy skin: major contributions of cutibacterium acnes to skin homeostasis.Microorganisms 9. https://doi.org/10.3390/microorganisms9030628
Kolli S, Pecone D, Pona A et al (2019) Topical retinoids in acne vulgaris: a systematic review. Am J Clin Dermatol 20:345–365. https://doi.org/10.1007/s40257-019-00423-z
Xu HX, Li HY (2019) Acne, the skin microbiome, and antibiotic treatment. Am J Clin Dermatol 20:335–344. https://doi.org/10.1007/s40257-018-00417-3
Khalil S, Bardawil T, Stephan C et al (2017) Retinoids: a journey from the molecular structures and mechanisms of action to clinical uses in dermatology and adverse effects. J Dermatol Treat 28:684–696. https://doi.org/10.1080/09546634.2017.1309349
Svoboda R, Nawaz N, Zaenglein A (2022) Hormonal treatment of acne and hidradenitis suppurativa in adolescent patients. Dermatol Clin 40:167–178. https://doi.org/10.1016/j.det.2021.12.004
Karadag AS, Aslan Kayıran M, Wu CY et al (2020) Antibiotic resistance in acne: changes, consequences and concerns. J Eur Acad Dermatol Venereol 35:73–78. https://doi.org/10.1111/jdv.16686
de Vries FMC, Meulendijks AM, Driessen RJB et al (2018) The efficacy and safety of non-pharmacological therapies for the treatment of acne vulgaris: a systematic review and best-evidence synthesis. J Eur Acad Dermatol Venereol 32:1195–1203. https://doi.org/10.1111/jdv.14881
Wilczynski S, Stolecka-Warzecha A, Deda A et al (2019) In vivo dynamic thermal imaging of skin radiofrequency treatment. J Cosmet Dermatol 18:1307–1316. https://doi.org/10.1111/jocd.12775
Bonjorno AR, Gomes TB, Pereira MC et al (2020) Radiofrequency therapy in esthetic dermatology: a review of clinical evidences. J Cosmet Dermatol 19:278–281. https://doi.org/10.1111/jocd.13206
Lolis MS, Goldberg DJ (2012) Radiofrequency in cosmetic dermatology: a review. Dermatol Surg 38:1765–1776. https://doi.org/10.1111/j.1524-4725.2012.02547.x
Ekelem C, Thomas L, Van Hal M et al (2019) radiofrequency therapy and noncosmetic cutaneous conditions. Dermatol Surg 45:908–930. https://doi.org/10.1097/DSS.0000000000001925
Abraham MT, Mashkevich G (2007) Monopolar radiofrequency skin tightening. Facial Plast Surg Clin North Am 15:169–177. https://doi.org/10.1016/j.fsc.2007.01.005
Gentile RD, Kinney BM, Sadick NS (2018) Radiofrequency technology in face and neck rejuvenation. Facial Plast Surg Clin North Am 26:123–134. https://doi.org/10.1016/j.fsc.2017.12.003
Ruiz-Esparza J, Gomez JB (2003) Nonablative radiofrequency for active acne vulgaris: the use of deep dermal heat in the treatment of moderate to severe active acne vulgaris (thermotherapy): a report of 22 patients. Dermatol Surg 29:333–339. https://doi.org/10.1046/j.1524-4725.2003.29081.x. (discussion 339)
Sadick NS, Nassar AH, Dorizas AS et al (2014) Bipolar and multipolar radiofrequency. Dermatol Surg 40 Suppl 12:S174-179. https://doi.org/10.1097/DSS.0000000000000201
Kim S (2008) The dual treatment of acne vulgaris using two kinds of ELOS (electro optical synergy) system: a simultaneous split-face trial. J Cosmet Laser Ther 10:213–216. https://doi.org/10.1080/14764170802071173
Prieto VG, Zhang PS, Sadick NS (2005) Evaluation of pulsed light and radiofrequency combined for the treatment of acne vulgaris with histologic analysis of facial skin biopsies. J Cosmet Laser Ther 7:63–68. https://doi.org/10.1080/14764170500231848
Kassim AT, Goldberg DJ (2013) Assessment of the safety and efficacy of a bipolar multi-frequency radiofrequency device in the treatment of skin laxity. J Cosmet Laser Ther 15:114–117. https://doi.org/10.3109/14764172.2013.764438
Yu JN, Huang P (2011) Use of a TriPollar radio-frequency device for the treatment of acne vulgaris. J Cosmet Laser Ther 13:50–53. https://doi.org/10.3109/14764172.2011.564626
Sadick NS, Shaoul J (2004) Hair removal using a combination of conducted radiofrequency and optical energies–an 18-month follow-up. J Cosmet Laser Ther 6:21–26. https://doi.org/10.1080/14764170410029013
Yoo KH, Ahn GR, Seok J et al (2017) Successful treatment of smallpox scars by using radiofrequency device with single microneedle. Int Wound J 14:1399–1400. https://doi.org/10.1111/iwj.12771
Ahn GR, Kim JM, Park SJ et al (2020) Selective sebaceous gland electrothermolysis using a single microneedle radiofrequency device for acne patients: a prospective randomized controlled study. Lasers Surg Med 52:396–401. https://doi.org/10.1002/lsm.23152
Cucu C, Butacu AI, Niculae BD et al (2021) Benefits of fractional radiofrequency treatment in patients with atrophic acne scars - literature review. J Cosmet Dermatol 20:381–385. https://doi.org/10.1111/jocd.13900
Kaminaka C, Uede M, Nakamura Y et al (2014) Histological studies of facial acne and atrophic acne scars treated with a bipolar fractional radiofrequency system. J Dermatol 41:435–438. https://doi.org/10.1111/1346-8138.12483
Kaminaka C, Uede M, Matsunaka H et al (2015) Clinical studies of the treatment of facial atrophic acne scars and acne with a bipolar fractional radiofrequency system. J Dermatol 42:580–587. https://doi.org/10.1111/1346-8138.12864
Kaminaka C, Furukawa F, Yamamoto Y (2016) Long-term clinical and histological effects of a bipolar fractional radiofrequency system in the treatment of facial atrophic acne scars and acne vulgaris in Japanese patients: a series of eight cases. Photomed Laser Surg 34:657–660. https://doi.org/10.1089/pho.2016.4116
Hendricks AJ, Farhang SZ (2022) Dermatologic facial applications of Morpheus8 fractional radiofrequency microneedling. J Cosmet Dermatol 21(Suppl 1):S11–S19. https://doi.org/10.1111/jocd.15231
Lee KR, Lee EG, Lee HJ et al (2013) Assessment of treatment efficacy and sebosuppressive effect of fractional radiofrequency microneedle on acne vulgaris. Lasers Surg Med 45:639–647. https://doi.org/10.1002/lsm.22200
Kim ST, Lee KH, Sim HJ et al (2014) Treatment of acne vulgaris with fractional radiofrequency microneedling. J Dermatol 41:586–591. https://doi.org/10.1111/1346-8138.12471
Hellman J (2015) Retrospective study of the use of a fractional radio frequency ablative device in the treatment of acne vulgaris and related acne scars. J Cosmet Dermatol Sci Appl 05:311–316. https://doi.org/10.4236/jcdsa.2015.54038
Lee SJ, Goo JW, Shin J et al (2012) Use of fractionated microneedle radiofrequency for the treatment of inflammatory acne vulgaris in 18 Korean patients. Dermatol Surg 38:400–405. https://doi.org/10.1111/j.1524-4725.2011.02267.x
Zeng R, Liu Y, Zhao W et al (2020) A split-face comparison of a fractional microneedle radiofrequency device and fractional radiofrequency therapy for moderate-to-severe acne vulgaris. J Cosmet Dermatol 19:2566–2571. https://doi.org/10.1111/jocd.13299
Min S, Park SY, Yoon JY et al (2015) Comparison of fractional microneedling radiofrequency and bipolar radiofrequency on acne and acne scar and investigation of mechanism: comparative randomized controlled clinical trial. Arch Dermatol Res 307:897–904. https://doi.org/10.1007/s00403-015-1601-z
Li J, Duan F, Kuang J (2022) Meta-analysis of fractional radiofrequency treatment for acne and/or acne scars. J Cosmet Dermatol 21:6754–6766. https://doi.org/10.1111/jocd.15348
Shin JU, Lee SH, Jung JY et al (2012) A split-face comparison of a fractional microneedle radiofrequency device and fractional carbon dioxide laser therapy in acne patients. J Cosmet Laser Ther 14:212–217. https://doi.org/10.3109/14764172.2012.720023
Kwon HH, Park HY, Choi SC et al (2018) Novel device-based acne treatments: comparison of a 1450-nm diode laser and microneedling radiofrequency on mild-to-moderate acne vulgaris and seborrhoea in Korean patients through a 20-week prospective, randomized, split-face study. J Eur Acad Dermatol Venereol 32:639–644. https://doi.org/10.1111/jdv.14714
Seok J, Kim JH, Kim JM et al (2019) Effects of intradermal radiofrequency treatment and intense pulsed light therapy in an acne-induced rabbit ear model. Sci Rep 9:5056. https://doi.org/10.1038/s41598-019-41322-x
Kim J, Lee YI, Kim J et al (2020) Safety of combined fractional microneedle radiofrequency and CO2 as an early intervention for inflammatory acne and scarring treated with concomitant isotretinoin. Dermatol Surg 46:e71–e77. https://doi.org/10.1097/DSS.0000000000002364
Austin GK, Struble SL, Quatela VC (2022) Evaluating the effectiveness and safety of radiofrequency for face and neck rejuvenation: a systematic review. Lasers Surg Med 54:27–45. https://doi.org/10.1002/lsm.23506
Dierickx CC (2006) The role of deep heating for noninvasive skin rejuvenation. Lasers Surg Med 38:799–807. https://doi.org/10.1002/lsm.20446
Polder KD, Bruce S (2011) Radiofrequency: thermage. Facial Plast Surg Clin North Am 19:347–359. https://doi.org/10.1016/j.fsc.2011.04.006
Naouri M, Mazer JM (2016) Non-insulated microneedle fractional radiofrequency for the treatment of scars and photoaging. J Eur Acad Dermatol Venereol 30:499–502. https://doi.org/10.1111/jdv.12890
Syder NC, Chen A, Elbuluk N (2023) Radiofrequency and radiofrequency microneedling in skin of color: a review of usage, safety, and efficacy. Dermatol Surg 49:489–493. https://doi.org/10.1097/DSS.0000000000003733
Paasch U, Bodendorf MO, Grunewald S et al (2009) Skin rejuvenation by radiofrequency therapy: methods, effects and risks. J Dtsch Dermatol Ges 7:196–203. https://doi.org/10.1111/j.1610-0387.2008.06780.x
(2020) Consensus recommendations for 4th generation non-microneedling monopolar radiofrequency for skin tightening: a delphi consensus panel. J Drugs Dermatol 19:20–26. https://doi.org/10.36849/JDD.2020.4807
Min S, Park SY, Yoon JY et al (2016) Fractional microneedling radiofrequency treatment for acne-related post-inflammatory erythema. Acta Derm Venereol 96:87–91. https://doi.org/10.2340/00015555-2164
Jung YJ, Ro YS, Ryu HJ et al (2020) Therapeutic effects of a new invasive pulsed-type bipolar radiofrequency for facial erythema associated with acne vulgaris and rosacea. J Cosmet Laser Ther 22:205–209. https://doi.org/10.1080/14764172.2021.1880599
Funding
This study was supported by National Natural Science Foundation of China (82304040); Jiangsu Provincial “Double Innovation Doctors” Program (grant number JSSCBS20211610); Provincial Natural Science Foundation of Yunnan(202301AT070393).
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XZ and RZ conceptualized the review idea. MZ and YL supervised the work.XZ involved in writing-original draft preparation. RZ and YL involved in writing-reviewing and editing. All authors have read and approved the final manuscript.
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Zhang, X., Zhou, M., Liu, Y. et al. Recent advances in the treatment of acne using radiofrequency techniques. Lasers Med Sci 39, 92 (2024). https://doi.org/10.1007/s10103-024-04039-6
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DOI: https://doi.org/10.1007/s10103-024-04039-6