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Efficacy and safety of 595-nm pulsed dye laser treating port wine stains in Vietnamese patients: analysis of 124 cases and optimal treatment regimens

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The purpose of this study is to determine the efficacy and safety of 595-nm pulsed dye laser (PDL) for port wine stains (PWS) treatment in Vietnamese patients. The study also analyzed the association between the response to treatment and the characteristics of patients and treatment regimens. Parallelly, the study contributed to further optimal treatment sessions for different subjects based on the data collected. One hundred twenty-five patients who underwent 595-nm PDL to treat PWS were included in the study, in which data from 124 patients was retrospectively analyzed. Data on demographic characteristics of patients, treatment regimens, and clinical improvement were collected. SPSS version 25 was used to analyze the relationship between associated factors and the response rate. The overall response rate of Vietnamese patients who had Fitzpatrick skin classification type III and IV was 73.4%. Age, gender, treatment sessions, and lesion positions were generally not associated with the response rate. The lesion grade was the sole element that affected the clinical improvement. The lesion grade 1 had the best response (100%) even after a short duration of treatment (six to ten treatments). Lesion grade 4 demanded over 16 treatments to reach > 60% of improvement. The lesion grades 1 and 2 could be blanched with regimen < 10 treatments while regimens exceeding 15 treatments should be carefully considered for lesions at grade 3 after evaluating associated conditions. Lesions at grade 4 demanded ≥ 16 treatments to reach acceptable outcomes. These results could help physicians establish a reasonable treatment strategy for patients.

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Data availability

Data used in this study could be provided by contacting the correspondence author upon reasonable requests.


  1. Barsky SH, Rosen S, Geer DE, Noe JM (1980) The nature and evolution of port wine stains: a computer-assisted study. J Invest Dermatol 74:154–157

    Article  CAS  PubMed  Google Scholar 

  2. Elias AJ, Hand JL, Tollefson MM, Davis DMR (2021) The anatomic distribution of isolated and syndrome-associated port-wine stain. Pediatr Dermatol 38:77–82

    Article  PubMed  Google Scholar 

  3. Shirley MD, Tang H, Gallione CJ, Baugher JD, Frelin LP, Cohen B, North PE, Marchuk DA, Comi AM, Pevsner J (2013) Sturge–Weber syndrome and port-wine stains caused by somatic mutation in GNAQ. N Engl J Med 368:1971–1979

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Lian CG, Sholl LM, Zakka LR, Liu C, Xu S, Stanek E, Garcia E, Jia Y, MacConaill LE, Murphy GF (2014) Novel genetic mutations in a sporadic port-wine stain. JAMA Dermatol 150:1336–1340

    Article  PubMed  Google Scholar 

  5. Nguyen V, Hochman M, Mihm MC Jr, Nelson JS, Tan W (2019) The pathogenesis of port wine stain and Sturge Weber syndrome: complex interactions between genetic alterations and aberrant MAPK and PI3K activation. Int J Mol Sci 20:2243

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Spring LK, Krakowski AC (2019) Port-Wine Birthmark and Hemangioma. In: Alam M (ed) Evidence-Based Procedural Dermatology. Springer International Publishing, Cham, pp 1003–1031.

    Chapter  Google Scholar 

  7. Sabeti S, Ball KL, Burkhart C, Eichenfield L, Faith EF, Frieden IJ, Geronemus R, Gupta D, Krakowski AC, Levy ML (2021) Consensus statement for the management and treatment of port-wine birthmarks in sturge-weber syndrome. JAMA Dermatol 157:98–104

    Article  PubMed  PubMed Central  Google Scholar 

  8. Loffeld A, Zaki I, Abdullah A, Lanigan S (2005) Study of patient-reported morbidity following V-beam pulsed-dye laser treatment of port wine stains. Lasers Med Sci 20:114–116

    Article  CAS  PubMed  Google Scholar 

  9. Koster PH, van der Horst CM, Bossuyt PM, van Gemert MJ (2001) Prediction of portwine stain clearance and required number of flashlamp pumped pulsed dye laser treatments. Lasers Surg Med: Official J Am Soc Laser Med Surg 29:151–155

    Article  CAS  Google Scholar 

  10. Tomson N, Lim S, Abdullah A, Lanigan S (2006) The treatment of port-wine stains with the pulsed-dye laser at 2-week and 6-week intervals: a comparative study. Br J Dermatol 154:676–679

    Article  CAS  PubMed  Google Scholar 

  11. Sadeghinia A, Moghaddas S, Tavakolpour S, Teimourpour A, Danespazhooh M, Mahmoudi H (2019) Treatment of port wine stains with 595-nm pulsed dye laser in 27 pediatric patients: a prospective study in the Iranian population. J Cosmet Laser Ther 21:373–377

    Article  PubMed  Google Scholar 

  12. Bae YSC, Ng E, Geronemus RG (2016) Successful treatment of two pediatric port wine stains in darker skin types using 595 nm laser. Lasers Surg Med 48:339–342

    Article  PubMed  Google Scholar 

  13. Wareham WJ, Cole RP, Royston SL, Wright PA (2009) Adverse effects reported in pulsed dye laser treatment for port wine stains. Lasers Med Sci 24:241–246

    Article  PubMed  Google Scholar 

  14. Woo SH, Ahn HH, Kim SN, Kye YC (2006) Treatment of vascular skin lesions with the variable pulse 595 nm pulsed dye laser. Dermatol Surg 32:41–48

    Article  CAS  PubMed  Google Scholar 

  15. Shi W, Wang J, Lin Y, Geng J, Wang H, Gong Y, Liu H, Zhang F (2014) Treatment of port wine stains with pulsed dye laser: a retrospective study of 848 cases in Shandong Province, People’s Republic of China. Drug Design Dev Ther 8:2531–2538

    Google Scholar 

  16. Li D, Chen B, Zhang H, Yuan Y, Fan W, Ying Z (2020) Retrospective study of the treatment of port-wine stains with 595-nm pulsed dye laser in 261 Chinese patients. Lasers Med Sci 35:1811–1819

    Article  PubMed  Google Scholar 

  17. Chatrath S, Silverberg JI (2023) Phenotypic differences of atopic dermatitis stratified by age. JAAD Int 11:1–7

    Article  PubMed  Google Scholar 

  18. Yu W, Ma G, Qiu Y, Chen H, Jin Y, Yang X, Hu X, Wang T, Chang L, Zhou H (2016) Why do port-wine stains (PWS) on the lateral face respond better to pulsed dye laser (PDL) than those located on the central face? J Am Acad Dermatol 74:527–535

    Article  PubMed  Google Scholar 

  19. Brightman LA, Geronemus RG, Reddy KK (2015) Laser treatment of port-wine stains. Clin Cosmet Investig Dermatol 8:27–33

    PubMed  PubMed Central  Google Scholar 

  20. Chapas AM, Eickhorst K, Geronemus RG (2007) Efficacy of early treatment of facial port wine stains in newborns: a review of 49 cases. Lasers Surg Med 39:563–568

    Article  PubMed  Google Scholar 

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Authors and Affiliations



Conceptualization, HTT; methodology, HTT; formal analysis and investigation, HTT, NXT, LTP, VTDT; data visualization, DVQH, NTM, PDH, VTDT; writing—original draft preparation, NXT, LTP, DVQH, NTM, PDH; writing—review and editing, HTT, VTDT; supervision, HTT

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Correspondence to Hoang Thanh Tuan.

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Ethics approval

The study complies with the Declaration of Helsinki. Ethical approval was waived by the Investigation Review Board of Hoang Tuan Clinic in view of the retrospective nature of the study and all the procedures being performed were part of the routine care.

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All patients agreed to the publication of their data.

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The authors declare no competing interests.

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Tuan, H.T., Tru, N.X., Phong, L.T. et al. Efficacy and safety of 595-nm pulsed dye laser treating port wine stains in Vietnamese patients: analysis of 124 cases and optimal treatment regimens. Lasers Med Sci 38, 258 (2023).

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