Skip to main content

Advertisement

Log in

The effects of photobiomodulation therapy in individuals with tinnitus and without hearing loss

  • Original Article
  • Published:
Lasers in Medical Science Aims and scope Submit manuscript

Abstract

To verify the effect of photobiomodulation therapy (PBMT) in individuals with chronic tinnitus without hearing loss, 20 patients who met the inclusion criteria were randomly divided into group 1: active low-level laser (LLL) and group 2: equipment without laser (placebo). Upon anamnesis, data collection, and audiological exams, the Tinnitus Handicap Inventory (THI) and the Visual-Analog Scale (EVA) were applied to measure the level of discomfort with tinnitus and the level of discomfort before and after laser treatment. The protocol used included 12 active LLL sessions for group 1 and not active for group 2, varying red and infrared wavelengths. There was a reduction in the disadvantage of individuals with tinnitus after the intervention and between the initial and final sessions, regardless of the intervention, although group 1 showed a greater reduction than group 2, regardless of point in time of assessment and number of session. There was no statistical difference as to group and point in time for the high-frequency audiometry and acuphenometry outcomes. Individuals with chronic tinnitus reduced the complaint, regardless of point in time and group of intervention; however, the group that received PBMT improved the level of satisfaction, regardless of point in time of assessment and number of session.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Mowafy ZME, Alsayed ARS, Hassan MESM (2016) Effect of Low Intensity Laser on Severe Tinnitus in Idiopathic Sudden Hearing Loss Patients. Int J Med Health Sci 3(6):1–6

    Google Scholar 

  2. Ngao CF, Tan TS, Narayanan RR (2013) The effectiveness of transmeatal low-power laser stimulation in treating tinnitus. Eur ArchOtorhinolaryngol 271(5):975–980

    Article  Google Scholar 

  3. Oostendorp RAB, Bakker I, Elvers H, Mikolajewska E, Michiels S, De Hertogh W et al (2016) Cervicogenic somatosensory tinnitus: an indication for manual therapy? Part 1. Man Ther 23:120–123

    Article  PubMed  Google Scholar 

  4. Sanchez TG, Medeiros IRT, Levy CPD, Ramalho JRO, Bento RF (2005) Tinnitus in normally hearing patients: clinical aspects and repercussions. Rev Bras Otorrinolaringol 71(4):427–431

    Article  Google Scholar 

  5. Oiticica J, Bittar RS (2015) Tinnitus prevalence in the city of São Paulo. Braz J Otorhinolaryngol 81(2):167–176

    Article  PubMed  Google Scholar 

  6. Suzuki FAB, Suzuki FA, Onishi ET, Penido NO (2018) Psychoacoustic classification of persistent tinnitus. Braz J Otorhinolaryngol 84(5):583–590

    Article  PubMed  Google Scholar 

  7. Dobie RA (2004) Overview: suffering from tinnitus. In: Snow JB. Tinnitus: theory and management cap. 1, p. 1–7. Shelton: PMPH-USA

  8. Tunkel DE, Bauer CA, Sun GH, Rosenfeld RM, Chandrasekhar SS, Cunningham ER et al (2014) Clinical Practice Guideline: tinnitus. Otolaryngol Head Neck Surg 151(2):1–40

    Article  Google Scholar 

  9. Santos AS (2016) Avaliação dos ensaios clínicos homeopáticos quanto a sua eficácia no tratamento de pacientes com zumbido. Monografia, Escola Baiana de Medicina e Saúde Pública.

  10. Montazeri K, Mahmoudian S, Razaghi Z, Farhadi M (2017) Alterations in auditory electrophysiological responses associated with temporary suppression of tinnitus induced by low-level laser therapy: a before-after case series. J Lasers Med Sci 8(1):38–45

    Article  Google Scholar 

  11. Henry JA, Roberts LE, Caspary DM, Theodoroff SM, Salvi RJ (2014) Underlying mechanisms of tinnitus: review and clinical implications. J Am Acad Audiol 25(1):5–22

    Article  PubMed  PubMed Central  Google Scholar 

  12. Rochkind S, Nissan M, Lubart R, Avran J, Bartal A (1988) The in-vivo-nerve response to direct low-energy-laser irradiation. Acta Neurochir 94(1–2):74–77

    Article  PubMed  CAS  Google Scholar 

  13. Shiomi Y, Takahashi H, Honjo I, Kojima H, Naito Y, Fujiki N (1997) Efficacy of transmeatal low power laser irradiation on tinnitus: a preliminary report. Auris Nasus Larynx 24(1):39–42

    Article  PubMed  CAS  Google Scholar 

  14. Schaffer M, Bone H, Sroka R, Schaffer PM, Reiser M, Dühmke E (2000) Effects of 780 nm diode laser irradiation on blood microcirculation: preliminary findings on time-dependent T1-weighted contrast-enhanced magnetic resonance imaging (MRI). J Photochem Photobiol B 54(1):55–60

    Article  PubMed  CAS  Google Scholar 

  15. Farivar S, Malekshahabi T, Shiari R (2014) Biological effects of low-level laser therapy. J Lasers Med Sci 5(2):58–62

    PubMed  PubMed Central  Google Scholar 

  16. Spanemberg JC, Figueiredo MA, Cherubini K, Salun FG (2016) Low-level laser therapy: a review of its applications in the management of oral mucosal disorders. Altern Ther Health Med 22(6):24–30

    PubMed  Google Scholar 

  17. Pacheco JA, Schapochnik A (2018) Fotobiomodulação, com laser de baixa intensidade, fotobiomodulação, nos músculos mastigatórios masseter e temporal para tratamento de bruxismo. Rev Cient Mult Núcl Conhecim 7(9):114–120

    Google Scholar 

  18. Estrela JV, Duarte CCF, Almeida DNA, Araruna VR, Silva RMV, Cavalcanti RL et al (2014) Efeito do led na flacidez tissular facial. Rev Catussaba 3(2):29–36

    Google Scholar 

  19. Tenis CA, Martins MD, Gonçalves MLL, Silva DFTD, Cunha Filho JJD, Martins MAT et al (2018) Efficacy of light-emitting diode (LED) photobiomodulation in pain management, facial edema, trismus, and quality of life after extraction of retained lower third molars. Medicine 97(37):1–6

    Article  Google Scholar 

  20. Poloni MM, Marques NP, Ribeiro Junior NV, Sperandio FF, Hanemann JAC, de Carli ML (2018) Bell’s palsy treated with photobiomodulation in an adolescent: Rare case report and review of the published literature. Int J Paediatr Dent 28(6):658–662

    Article  PubMed  Google Scholar 

  21. Hamblin MR (2016) Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. AIMS Biophys 4(3):337–361

    Article  Google Scholar 

  22. Hamblin MR (2016) Shining light on the head: Photobiomodulation for brain disorders. BBA Clin 6:113–124

    Article  PubMed  PubMed Central  Google Scholar 

  23. Mirz F, Zachariae R, Andersen SE, Nielsen AG, Johansen LV, Bjerring P et al (1999) The low-power laser in the treatment of tinnitus. Clin Otolaryngol Allied Sci 24(4):346–354

    Article  PubMed  CAS  Google Scholar 

  24. Teggi R, Bellini C, Piccioni LO, Bussi M (2009) Transmeatal low-level laser therapy for chronic tinnitus with cochlear dysfunction. Audiol Neurotol 14(2):115–120

    Article  CAS  Google Scholar 

  25. Mollasadeghi A, Mirmohammadi SJ, Mehrparvar AH, Davari MH, Shokouh P, Mostaghaci M et al (2013) Efficacy of low-level laser therapy in the management of tinnitus due to noise-induced hearing loss: a double-blind randomized clinical trial. Scientific World J 28(2013):1–7

    Article  Google Scholar 

  26. Tamura A, Matsunobu T, Mizutari K, Niwa T, Kawauchi S, Satoh S et al (2015) Low-level laser therapy for prevention of noise-induced hearing loss in rats. Neurosci Lett 19(595):81–86

    Article  Google Scholar 

  27. Peng Z, Chen XQ, Gong SS, Chen CF (2012) Low-level laser therapy for tinnitus. Cochrane DB Syst Rev 1–15

  28. Tauber S, Baumgartner R, Schorn K, Beyer W (2000) Lightdosimetric quantitative analysis of the human petrous bone: experimental study for laser irradiation of the cochlea. Lasers Surg Med 28(1):18–26

    Article  Google Scholar 

  29. Tauber S, Schorn K, Beyer W, Baumgartner R (2003) Transmeatal cochlear laser (TCL) treatment of cochlear dysfunction: A feasibility study for chronic tinnitus. Lasers Med Sci 18(3):154–161

    Article  PubMed  CAS  Google Scholar 

  30. Procházková K, Sejna I, Schalek P, Rosina J, Hahn A (2015) A Combination of EGb 761 and soft laser therapy in chronic tinnitus. Update Hear Loss 1–9

  31. Ferreira MC, De Matos IL, De Toledo IP, Honório HM, Mondelli MFCG (2021) Effects of Low-Level Laser Therapy as a Therapeutic Strategy for Patients With Tinnitus: A Systematic Review. J Speech Lang Hear Res 64:279–298

    Article  PubMed  Google Scholar 

  32. WHO - World Health Organization. Grades of hearing impairment. 2017. <http://www.who.int/deafness/hearing_impairment_grades/en/>

  33. Ferreira PEA, Cunha F, Onishi ET, Branco-Barreiro FCA, Ganança FF (2005) Tinnitus handicap inventory: cross-cultural adaptation to Brazilian Portuguese. Pro-Fono R Atual Cient 17(3):303–310

    Article  Google Scholar 

  34. Dehkordi MA, Einolghozati S, Ghasemi SM, Abolbashari S, Meshkat M, Behzad H (2015) Effect of low-level laser therapy in the treatment of cochlear tinnitus: a double-blind, placebo-controlled study. Ear Nose Throat J 94(1):32–36

    PubMed  Google Scholar 

  35. Scheffer AR, Mondelli MFCG (2020) Tinnitus and Hearing Survey: adaptação cultural para o Português Brasileiro. Braz J Otorhinolaryngol in press

  36. Shore SE, Wu C (2019) Mechanisms of Noise-Induced Tinnitus: Insights from Cellular Studies. Neuron 103:8–20

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  37. Stohler NA, Reinau D, Jick SS, Bodmer D, Meier CR (2019) A study on the epidemiology of tinnitus in the United Kingdom. Clin Epidemiol 11:855–871

    Article  PubMed  PubMed Central  Google Scholar 

  38. Goodman SS, Bentler RA, Dittberner A, Mertes IB (2013) The effect of low-level laser therapy on hearing. ISRN Otolaryngol 2013:1–9

    Article  Google Scholar 

  39. Moon T, Lee MY, Jung JY, Chang SY, Chung PS, Rhee CK et al (2016) Safety assessment of trans-tympanic photobiomodulation. Lasers Med Sci 31(2):323–333

    Article  PubMed  Google Scholar 

  40. Okhovat A, Berjis N, Okhovat H, Malekpour A, Abtahi H (2011) Low-level laser for treatment of tinnitus: a self-controlled clinical trial. J Res Med Sci 16(1):33–8

    PubMed  PubMed Central  Google Scholar 

  41. Chang SY, Lee MY, Chung PS, Kim S, Choi B, Suh MW et al (2019) Enhanced mitochondrial membrane potential and ATP synthesis by photobiomodulation increases viability of the auditory cell line after gentamicin-induced intrinsic apoptosis. Nature 9:19248

    CAS  Google Scholar 

  42. Baguley D, McFerran D, Hall D (2013) Tinnitus Lancet 382:1600–1607

    Article  PubMed  Google Scholar 

  43. Chavantes MC (2009) Laser em Bio-medicina: princípios e prática. Atheneu, São Paulo, p 281

    Google Scholar 

  44. Ailioaie LM, Litscher G, Webwe M, Ailoaie C, Litscher D, Chiran DA (2014) Innovations and challenges by applying sublingual laser blood irradiation in juvenile idiopathic arthritis. Int J Photoenergy 2014:1–8

    Article  Google Scholar 

  45. Silva T, Silva FC, Gomes AO, Viana AO, Gonçalves MLL, Rodrigues MFSD et al (2018) Effect of photobiomodulation treatment in the sublingual, radial artery region, and along the spinal column in individuals with multiple sclerosis. Medicine 97(19):1–4

    Article  Google Scholar 

  46. Salahaldin AH, Abdulhadi K, Bener A (2012) Low-level laser therapy in patients with complaints of tinnitus: a clinical study. ISRN Otolaryngol 2012:1–5

    Article  Google Scholar 

  47. Oppitz SJ, Silva LCL, Garcia MV, Silveira AF (2018) Limiares de audibilidade de altas frequências em indivíduos adultos normo-ouvintes. CoDAS 30(4):1–7

    Article  Google Scholar 

  48. Mirz F, Zachariae R, Andersen SE, Nielsen AG, Johansen LV, Bjerring P et al (1999) The low-power laser in the treatment of tinnitus. Clin Otolaryngol 24:346–354

    Article  PubMed  CAS  Google Scholar 

  49. Park YM, Na WS, Park IY, Suh MW, Rhee CK, Chung PS et al (2013) Trans-canal laser irradiation reduces tinnitus perception of salicylate treated rat. Neurosci Lett 544:131–135

    Article  PubMed  CAS  Google Scholar 

  50. Rhee C-K, Bahk CW, Kim SH, Ahn JC, Jung JY, Chung PS, Suh MW (2012) Effect of low-level laser treatment on cochlea hair cell recovery after acute acoustic trauma. J Biomed Optics 17(6):068002

    Article  Google Scholar 

  51. Montazeri K, Mahmoudian S, Razaghi Z, Farhadi M (2017) Alterations in Auditory Electrophysiological Responses Associated With Temporary Suppression of Tinnitus Induced by Low-Level Laser Therapy: A Before-After Case Series. J Lasers Med Sci 8(Suppl 1):S38–S45

    Article  PubMed  PubMed Central  Google Scholar 

  52. Okhovat A, Berjis N, Okhovat H, Malekpour A, Abtahi H (2011) Low-level laser for treatment of tinnitus: a self-controlled clinical trial. JRMS 16(1):33–38

    PubMed  PubMed Central  Google Scholar 

  53. Chandra N, Chang K, Lee A, Shekhawat GS, Searchifield GD (2018) Psychometric validity, reliability, and responsiveness of the Tinnitus Functional Index. J Am Acad Audiol 29(7):609–625

    Article  PubMed  Google Scholar 

  54. Siedentopf CM, Ischebeck A, Haala IA, Mottaghy FM, Schikora D, Verius M et al (2007) Neural correlates of transmeatal cochlear laser (TCL) stimulation in healthy human subjects. Neurosci Lett 411:189–193

    Article  PubMed  CAS  Google Scholar 

  55. Swain SK, Nayak S, Ravan JR, Sahu MC (2016) Tinnitus and its current treatment–Still an enigma in medicine. J Formos Med Assoc 115(3):139–144

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

Maria Fernanda, Capoani Garcia Mondelli, and Maria Cristina Chavantes: study conception and design, assistance in data interpretation, submission and procedures of the article, preparation, correction, and final approval of the version to be submitted for publication.

Mirele Regina Silva: data collection, data analysis, data interpretation, literature review, and preparation of article.

Amanda Rodrigues Scheffer: collaboration in data collection and preparation of article.

Roberto Sávio de Assunção Bastos: critical review of relevant intellectual content.

Corresponding author

Correspondence to Mirele Regina Silva.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This work carried out at the Speech Therapy Department, Bauru School of Dentistry, University of São Paulo – USP – Bauru (SP), Brazil.

Rights and permissions

Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Silva, M.R., Scheffer, A.R., de Assunção Bastos, R.S. et al. The effects of photobiomodulation therapy in individuals with tinnitus and without hearing loss. Lasers Med Sci 37, 3485–3494 (2022). https://doi.org/10.1007/s10103-022-03614-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10103-022-03614-z

Keywords

Navigation