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Long-term results of micropulse laser trabeculoplasty with 577-nm yellow wavelength in patients with uncontrolled primary open-angle glaucoma and pseudoexfoliation glaucoma

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Abstract

Our aim was to evaluate the long-term results of micropulse laser trabeculoplasty (MLT) with 577-nm yellow wavelength in the treatment of glaucoma. We reviewed the medical records of 51 patients (51 eyes) with uncontrolled primary open-angle glaucoma or pseudoexfoliation glaucoma who underwent 180° MLT for the first time. The success of MLT was defined as an IOP reduction of ≥ 20% and IOP < 21 mmHg after treatment. If the number of medications was increased or further laser trabeculoplasty or glaucoma surgery was required after treatment, the case was considered unsuccessful. The mean duration of patient follow-up was 18.39 ± 12.17 months (range 3–52 months). Patients included in the study used 2–4 types of antiglaucoma eye drops (mean 3.43 ± 0.7). The mean number of MLT spots was 65.54 ± 6.19, and the mean energy level was 750.98 ± 101.73 mJ. The decrease in intraocular pressure compared to baseline measurements was: 16.72 ± 11.87%, 15.07 ± 13.76%, 12.63 ± 14.29%, 16.66 ± 19.32%, and 16.75 ± 19.78% during follow-up at 3, 6, 12, 24, and 36–48 months. Successful response was achieved in 35.41%, 36.95%, 34.21%, 40%, 41.17%, and 42.85% of patients during 3, 6, 12, 18, 24, and 36–48 months of follow-ups, respectively. Of the 51 eyes studied, 12 patients (23.5%) underwent post-MLT glaucoma surgery, and 7 patients (13.7%) had cataract surgery, whose follow-up data were subsequently censored. The reduction of intraocular pressure showed a significant correlation with baseline intraocular pressure, while age and laser power showed no correlation (p > 0.05). MLT is a novel treatment option for patients with glaucoma with favorable long-term outcomes and a good safety profile.

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Authors and Affiliations

  1. Department of Ophthalmology, Fatih Sultan Mehmet Training and Research Hospital, University of Health Sciences, Istanbul, Turkey

    Sevda Aydin Kurna, Ayse Demirciler Sonmez & Murat Yamic

  2. Department of Ophthalmology, Bahçeşehir University, Istanbul, Turkey

    Ahmet Altun

Authors
  1. Sevda Aydin Kurna
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  2. Ayse Demirciler Sonmez
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  3. Murat Yamic
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  4. Ahmet Altun
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Contributions

All the authors contributed to the study’s conception and design. Material preparation, data collection, and analysis were performed by Sevda Aydın Kurna, Ayse Demirciler Sonmez, and Murat Yamic. The first draft of the manuscript was written by Sevda Aydın Kurna and all the authors commented on the previous versions of the manuscript. All the authors read and approved the final manuscript.

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Correspondence to Sevda Aydin Kurna.

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This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Institutional Review Board of Fatih Sultan Mehmet Training and Research Hospital (Date: 26–12-2016/No. 4722).

The computer software for statistical analysis is with the corresponding author and can be provided on request.

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The authors declare no competing interests.

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Aydin Kurna, S., Sonmez, A.D., Yamic, M. et al. Long-term results of micropulse laser trabeculoplasty with 577-nm yellow wavelength in patients with uncontrolled primary open-angle glaucoma and pseudoexfoliation glaucoma. Lasers Med Sci 37, 2745–2752 (2022). https://doi.org/10.1007/s10103-022-03550-y

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