Abstract
Pancreatic cancer (PC) is a leading cause of cancer death and its incidence and mortality have shown an increasing trend. Despite improvements in outcomes, another treatment option is required for PC. Laser ablation (LA) has been evaluated for the treatment of various types of cancer. The aim of this study was to assess the safety and feasibility of a novel cylindrical light diffuser in a xenograft model of PC. This study was performed using a customized high-power laser system. PANC-1 cells and BALB/c mice were used for experiments at a laser power of 5 W for 40 to 200 s at five different energy levels (n = 30). There was no acute bleeding or major complication. Using the cylindrical light diffuser, tumors were irradiated with similar size in each energy group. A correlation between laser dose and tumor necrosis was observed. Pearson’s correlation for the relation between the amount of necrosis area and laser ablation energy on day 3 was 0.78 (p < 0.01). No statistical difference of necrosis area was exhibited when the necrosis area of each harvested tumor analyzed by dividing into 5 specimens for each energy. The study demonstrates that LA treatment using a cylindrical light diffuser induced remarkable tumor necrosis at histopathologic examinations. Laser ablation dosage and tumor response were strongly correlated, and the ablation procedure resulted in homogeneous tissue necrosis. No adverse event was encountered. These findings suggest that the devised cylindrical light diffuser offers a safe and effective means of treating pancreatic cancer.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209–249
Ferlay J, Partensky C, Bray F (2016) More deaths from pancreatic cancer than breast cancer in the EU by 2017. Acta Oncol 55:1158–1160
Paniccia A, Edil BH, Schulick RD, Byers JT, Meguid C, Gajdos C, McCarter MD (2014) Neoadjuvant FOLFIRINOX application in borderline resectable pancreatic adenocarcinoma: a retrospective cohort study. Medicine (Baltimore) 93:e198
Kim YI, Song KB, Lee YJ, Park KM, Hwang DW, Lee JH, Shin SH, Kwon JW, Ro JS, Kim SC (2019) Management of isolated recurrence after surgery for pancreatic adenocarcinoma. Br J Surg 106:898–909
Yamamoto T, Uchida Y, Terajima H (2019) Clinical impact of margin status on survival and recurrence pattern after curative-intent surgery for pancreatic cancer. Asian J Surg 42:93–99
Esposito I, Kleeff J, Bergmann F, Reiser C, Herpel E, Friess H, Schirmacher P, Büchler MW (2008) Most pancreatic cancer resections are R1 resections. Ann Surg Oncol 15:1651–1660
DiMagno EP, Buxton JL, Regan PT, Hattery RR, Wilson DA, Suarez JR, Green PS (1980) Ultrasonic endoscope. Lancet 1:629–631
Di Matteo FM, Saccomandi P, Martino M, Pandolfi M, Pizzicannella M, Balassone V, Schena E, Pacella CM, Silvestri S, Costamagna G (2018) Feasibility of EUS-guided Nd:YAG laser ablation of unresectable pancreatic adenocarcinoma. Gastrointest Endosc 88:168-174 e161
Schena E, Saccomandi P, Fong Y (2017) Laser ablation for cancer: past, present and future. J Funct Biomater 8:020019
Lee J, Park HY, Kim WW, Jeong JY, Lee YD, Choi MH, Kim S, Park JY, Jung JH (2017) Combination treatment with photodynamic therapy and laser ablation in breast cancer: an animal model study. Photomed Laser Surg 35:505–512
Rosenberg C, Tadir Y, Braslavsky D, Fisch B, Karni Z, Ovadia J (1990) Endometrial laser ablation in rabbits: a comparative study of three laser types. Lasers Surg Med 10:66–73
Ueki M, Inoki C, Ueda M, Tsutsumi A, Nakazato M, Daikuzono N (1996) Experimental and clinical studies on balloon laserthermia using Nd: YAG laser for uterine endometrial cancer. Lasers Surg Med 18:178–186
McKenzie AL (1990) Physics of thermal processes in laser-tissue interaction. Phys Med Biol 35:1175–1209
Azadgoli B, Baker RY (2016) Laser applications in surgery. Ann Transl Med 4:452
Francica G, Petrolati A, Di Stasio E, Pacella S, Stasi R, Pacella CM (2012) Effectiveness, safety, and local progression after percutaneous laser ablation for hepatocellular carcinoma nodules up to 4 cm are not affected by tumor location. AJR Am J Roentgenol 199:1393–1401
Beisland HO, Sander S, Fossberg E (1985) Neodymium:YAG laser irradiation of urinary bladder tumors. Follow-up study of 100 consecutively treated patients. Urology 25:559–563
Kramer MW, Bach T, Wolters M, Imkamp F, Gross AJ, Kuczyk MA, Merseburger AS, Herrmann TR (2011) Current evidence for transurethral laser therapy of non-muscle invasive bladder cancer. World J Urol 29:433–442
Kang HW, Kim J, Oh J (2012) Enhanced photocoagulation with catheter-based diffusing optical device. J Biomed Opt 17:118001
Funding
This work was supported by the Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (Project Number: 1711139013, KMDF_PR_20200901_0155) (NTIS, KMDF-RnD 202016B01) and INHA UNIVERSITY research grant.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of interest
The authors declare no competing interests.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Lee, J., Lee, S., Truong, V.G. et al. Laser ablation of pancreatic cancer using a cylindrical light diffuser. Lasers Med Sci 37, 2615–2621 (2022). https://doi.org/10.1007/s10103-022-03527-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10103-022-03527-x