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The effects of photobiomodulation using LED on the repair process of skin graft donor sites

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Abstract

The benefits of photobiomodulation (PBM) applied to wounds are well-described in the literature; however, its effects in skin graft donor sites have been poorly studied. The aim of this study is to evaluate the effects of LED PBM on re-epithelialization and wound quality of the skin donor site and on pain during repair process. This is a case series study that part of the patients received standard treatment and the others received standard treatment combined with PBM. Data collection was performed at the Burn Unit at a Public Hospital, Brazil. The study had 21 participants and 25 donor sites, 13 in the control group (conventional treatment with Membracel® bandage) and 12 in the experimental group (Membracel® + LED). Irradiation parameters were 1.53 J/cm2, 2.55 mW/cm2, 660 nm, 600 s in the immediate postoperative period as well as on the 1st, 3rd, 5th, and 7th days postoperatively. Pain was measured using the visual analog scale. The Bates-Jensen scale was used to monitor the re-epithelialization process and measurements were performed of donor skin sites in the postoperative period. Quantitative variables were expressed as mean ± standard deviation or median and interquartile range [p25; p75]. The comparison of the distribution of these variables between groups was performed using the Mann–Whitney test. No differences between groups were found for re-epithelialization time, area or quality of the wound. Regarding pain, a significant reduction was found on the 5th postoperative day in the experimental group compared to the control group. PBM did not induce changes in the re-epithelialization period, wound area or wound quality scores of the Bates-Jensen Scale but did induce a reduction in pain compared to the group treated with Membracel® alone.

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Data availability

The data that support the findings of this study are available from the corresponding author, [Mesquita-Ferrari, RA*], upon reasonable request.

Code availability

Not applicable.

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Funding

This work was supported by UNINOVE and the Brazilian fostering agencies: Coordination for the Improvement of Higher Education Personnel (CAPES; Contract grant number: 88882.365372/2019–01); The National Council for Scientific and Technological Development (CNPq) (306718/2018–9).

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Authors and Affiliations

  1. Postgraduate Program in Biophotonics Applied To Health Sciences, Universidade Nove de Julho, Liberdade, São Paulo, Brazil

    Rosadélia Malheiros Carboni, Marcela Leticia Leal Gonçalves, Daniela Fátima Teixeira Silva, Sandra Kalil Bussadori, Kristianne Porta Santos Fernandes, Anna Carolina Ratto Tempestini Horliana & Raquel Agnelli Mesquita-Ferrari

  2. Department of Plastic Surgery, Burn Center Unit, Hospital Geral “Dr, José Pangella” de Vila Penteado, São Paulo, Brazil

    Elaine Marlene Tacla

  3. Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho, Liberdade, São Paulo, Brazil

    Sandra Kalil Bussadori & Raquel Agnelli Mesquita-Ferrari

Authors
  1. Rosadélia Malheiros Carboni
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  2. Marcela Leticia Leal Gonçalves
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  3. Elaine Marlene Tacla
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  4. Daniela Fátima Teixeira Silva
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  7. Anna Carolina Ratto Tempestini Horliana
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  8. Raquel Agnelli Mesquita-Ferrari
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Correspondence to Raquel Agnelli Mesquita-Ferrari.

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Carboni, R.M., Gonçalves, M.L.L., Tacla, E.M. et al. The effects of photobiomodulation using LED on the repair process of skin graft donor sites. Lasers Med Sci 37, 1881–1890 (2022). https://doi.org/10.1007/s10103-021-03447-2

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