Effects of diode low-level laser therapy on healing of tooth extraction sockets: a histopathological study in diabetic rats


Diabetes mellitus is mostly interrelated to deficiency in wound healing. Low-level laser therapy has been shown to exert reliable effects on the acceleration of wound healing process. This study aimed to determine the potential influence of low-level laser therapy (LLLT) on the healing of extraction sockets in diabetic rats. A total of 24 healthy male Wistar rats were selected for this study. After diabetes induction, the maxillary first molars of all rats were extracted bilaterally. Then, the animals were subjected either to Ga-Al-As laser at 808 nm or to Al-Ga-In-P laser at 660 nm at the right extracted socket every day for the next 14 days. The left sockets served as controls. Rats were sacrificed on the 3rd, 5th, 7th, and 14th days after tooth extraction. The samples were examined by a pathologist. LLLT at 808 nm was able to significantly repress inflammation, improve osteoid formation, and promote vascularization in comparison to the non-treated sockets. LLLT at 660 nm significantly suppressed inflammation and developed vascularization in comparison to the non-treated sockets, but failed to improve osteoid formation in the treated sockets. This study suggests that LLLT could be considered as a reliable treatment for wound healing in diabetic experimental rats.

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This paper has been financially supported by the Vice Chancellor for Research of Mashhad University of Medical Sciences (MUMS) (Grant number: 931747). The results described in this study was part of a D.D.S student thesis.

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Correspondence to Hamideh Salari Sedigh or Reyhaneh Shafieian.

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Dalirsani, Z., Ghazi, N., Delavarian, Z. et al. Effects of diode low-level laser therapy on healing of tooth extraction sockets: a histopathological study in diabetic rats. Lasers Med Sci (2021). https://doi.org/10.1007/s10103-021-03270-9

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  • Low-level laser therapy
  • Diabetes mellitus
  • Tooth socket