Modulatory effect of photobiomodulation on stem cell epigenetic memory: a highlight on differentiation capacity

  • Arezoo Rezaie Nezhad Zamani
  • Shirin Saberianpour
  • Mohammad Hossein Geranmayeh
  • Farhad Bani
  • Leila Haghighi
  • Reza RahbarghaziEmail author
Review Article


Differentiation potential of stem cells into various lineages makes these cells as promising sources to treat multiple diseases. In this regard, the use of different strategies and protocols to increase differentiation capacity is highly demanded. Low-level laser therapy, a relatively noninvasive technique, has the capacity to accelerate the healing of numerous injuries and a portion of restorative capacity could be correlated with the stem cell activation and differentiation. Several mechanisms have been diagnosed to participate in orientation of stem cells to functional mature cells. Among them, the status of DNA methylation orchestrates the maintenance of tissue-specific gene expression during the differentiation procedure. DNA methylation is a momentous event in embryogenesis and functional maturation. This review article highlighted the potency of laser irradiation (low-level intensities) in the differentiation of stem cells by modulation of methylation. The analysis of these modalities could help us to understand the underlying mechanisms participating in the therapeutic effects of photobiomodulation.


Stem cells Low-level laser irradiation DNA methylation Differentiation 



We would thank the personnel of Stem Cell Research Center for collaboration.

Authors’ contributions

A.R.N.Z., S.S., M.H.G., F.B., and L.H. collected the data and wrote manuscript. R. R. conducted the study.

Funding information

This manuscript is supported by a grant from Tabriz University of Medical Sciences.

Compliance with ethical standards

Conflict of interest

The authors declare that there is no conflict of interest.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2019

Authors and Affiliations

  1. 1.Stem Cell Research CenterTabriz University of Medical SciencesTabrizIran
  2. 2.Neuroscience Research Center, Imam Reza Medical CenterTabriz University of Medical SciencesTabrizIran
  3. 3.Department of Medical Nanotechnology, Faculty of Advanced Medical SciencesTabriz University of Medical SciencesTabrizIran
  4. 4.Department of Parasitology and Mycology, School of MedicineIran University of Medical SciencesTehranIran
  5. 5.Department of Applied Cell Sciences, Faculty of Advanced Medical SciencesTabriz University of Medical SciencesTabrizIran

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