Lasers in Medical Science

, Volume 34, Issue 7, pp 1345–1351 | Cite as

A pilot prospective study of 577-nm yellow subthreshold micropulse laser treatment with two different power settings for acute central serous chorioretinopathy

  • Lijun Zhou
  • Victor Chong
  • Kunbei Lai
  • Chuangxin Huang
  • Fabao Xu
  • Yajun Gong
  • Maimaitiaili Youlidaxi
  • Tao Li
  • Lin Lu
  • Chenjin JinEmail author
Original Article


To compare the efficacy of 50% threshold power with 25% threshold power of 577-nm subthreshold micropulse laser (SMPL) for acute central serous chorioretinopathy (CSC). Prospective, interventional, non-randomized, comparative case series. A total of 54 patients (54 eyes) with acute CSC were enrolled. Twenty-four eyes received 25% threshold power and 30 eyes received 50% threshold power of 577-nm SMPL. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and complete absorption of subretinal fluid (SRF) were evaluated at 1 month and 3 months. The complete absorption rate of SRF in the 50% power group was significantly greater than that in the 25% power group at 1 month (70.0% vs 25.0%, p < 0.001) and at 3 months (83.3% vs 54.2%, p < 0.001). Mean BCVA improved from 0.34 ± 0.20 LogMAR to 0.02 ± 0.13 LogMAR in the 50% power group and from 0.27 ± 0.15 LogMAR to 0.14 ± 0.21 LogMAR in the 25% power group with a significant difference between the two groups after 3 months (p = 0.027). In the 50% power group, the CMT decreased from 491.6 ± 154.8 μm at baseline to 231.3 ± 92.3 μm at 1 month and 228.2 ± 88.1 μm at 3 months, and in the 25% power group, the CMT decreased from 444.9 ± 164.1 to 306.8 ± 102.6 μm at 1 month and 254.5 ± 101.7 μm at 3 months. There was statistical difference of CMT at 1 month (p = 0.009) but no significant difference at 3 months between the two groups (p = 0.232). SMPL with 50% threshold power may be more effective than 25% threshold power for acute CSC.


Subthreshold micropulse laser Acute central serous chorioretinopathy Titration power 



The authors would like to thank all staff involved in the care of patient presented in this study.

Financial support

Supported by National Natural Science Foundation of China (81670866).

Compliance with ethical standards

Conflict of interest

All authors have no financial or other conflicts of interest concerning this study. VC is a consultant of Quantel Medical and an employee of Boehringer Ingelheim.

Informed consent

Written informed consents were obtained from the patients before treatment.

Ethical approval

This study was approved by the Ethics Committee of Zhongshan Ophthalmic Center of Sun Yat-Sen University and was conducted in adherence with the tenets of the Declaration of Helsinki.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2019

Authors and Affiliations

  1. 1.State Key Laboratory of OphthalmologyZhongshan Ophthalmic Center, Sun Yat-Sen UniversityGuangzhou CityChina
  2. 2.Optegra Eye HospitalLondonUK
  3. 3.The First People’s Hospital of KashgarKashgarChina

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