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Blue laser imaging with acetic acid enhancement improved the detection rate of gastric intestinal metaplasia

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Abstract

Our aim was to evaluate the ability of blue laser imaging (BLI) combined with acetic acid (BLI-AA) to detect gastric intestinal metaplasia (GIM). Participants undergoing gastroscopy from July 2017 to February 2018 in our hospital were enrolled prospectively. The abilities of white light imaging endoscopy, BLI endoscopy, and BLI-AA to detect GIM were compared. One hundred six patients undergoing gastroscopy met the inclusion criteria. GIM was diagnosed in 41 patients. For BLI-AA, the sensitivity, specificity, positive predictive, and negative predictive values were 85.4%, 84.6%, 77.8%, and 90.2% respectively. The diagnostic accuracy rate for BLI-AA was 84.9%, which was higher than that of white light imaging endoscopy and BLI endoscopy. For target biopsy, the GIM detection rate for the BLI-AA mode was significantly higher (77.8%, 105/135) than that for the BLI mode (58.3%, 84/144) or the white light endoscopy mode (40.4%, 57/141) (p < 0.05). BLI-AA is an efficient and simple method for the detection of GIM.

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Funding

This study was supported by the National Key Clinical Discipline and Guangdong Institute of Gastroenterology.

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Authors and Affiliations

  1. Department of Gastrointestinal Endoscopy, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, No.26 Yuancun Er Heng Rd, Tianhe District, Guangzhou, 510655, Guangdong Province, People’s Republic of China

    Honglei Chen, Yanan Liu, Qiuning Wu, Yi Lu & Chujun Li

  2. Department of Gastrointestinal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, No.26 Yuancun Er Heng Rd, Tianhe District, Guangzhou, 510655, Guangdong Province, People’s Republic of China

    Xiaobin Wu

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  1. Honglei Chen
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  2. Xiaobin Wu
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  3. Yanan Liu
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  4. Qiuning Wu
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  5. Yi Lu
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  6. Chujun Li
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Corresponding authors

Correspondence to Honglei Chen or Chujun Li.

Ethics declarations

Written informed consent was obtained from all participants. This study, which was approved by the Ethics Committee of the Sixth Affiliated Hospital of Sun Yat-sen University, was registered in the Chinese Clinical Trial Registry (ChiCTR-DDD-17011370) and conducted following the Declaration of Helsinki.

Conflict of interest

Honglei Chen has received funding from Guangdong province medical science and technology research fund project (grant number: A2017273). For the remaining authors, none were declared.

Additional information

Honglei Chen and Xiaobin Wu are the co-first author in this study.

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Chen, H., Wu, X., Liu, Y. et al. Blue laser imaging with acetic acid enhancement improved the detection rate of gastric intestinal metaplasia. Lasers Med Sci 34, 555–559 (2019). https://doi.org/10.1007/s10103-018-2629-z

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  • DOI: https://doi.org/10.1007/s10103-018-2629-z

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