To compare the efficacy and safety of UVA1 and narrowband UVB (NB-UVB) therapy in the treatment of scalp psoriasis. Patients with scalp psoriasis were randomly assigned to either UVA1 or NB-UVB therapy. Both treatments were performed three times weekly for 6 weeks. Clinical efficacy was evaluated by using Psoriasis Scalp Severity Index (PSSI), and patient-reported quality of life (QoL) was assessed by Dermatology Life Quality Index (DLQI). Totally 68 patients completed the study. Both UVA1 and NB-UVB phototherapy achieved a statistically significant reduction of PSSI and DLQI scores at the end of the treatment period. Compared with the NB-UVB group, the significantly greater improvements occurred in UVA1 treatment group at week 3, although differences declined thereafter through week 10. Both UVA1 and NB-UVB therapy were well-tolerated in this study, and the occurrence of adverse events (AEs) was uncommon. Both UVA1 and NB-UVB phototherapy could offer relief of scalp symptoms in patients with scalp involvement. Furthermore, UVA1 treatment could improve the clinical manifestations and QoL more quickly than NB-UVB therapy.
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Parisi R, Symmons DP, Griffiths CE, Ashcroft DM (2013) Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Investig Dermatol 133:377–385
Wozel G, Klein E, Mrowietz U, Reich K, Sebastian M, Streit V (2011) Scalp psoriasis. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 9:70–74
Ortonne J, Chimenti S, Luger T, Puig L, Reid F, Trueb RM (2009) Scalp psoriasis: European consensus on grading and treatment algorithm. J Eur Acad Dermatol Venereol 23:1435–1444
Bagel J, Lynde C, Tyring S, Kricorian G, Shi Y, Klekotka P (2012) Moderate to severe plaque psoriasis with scalp involvement: a randomized, double-blind, placebo-controlled study of etanercept. J Am Acad Dermatol 67:86–92
Tyring S, Bagel J, Lynde C et al (2013) Patient-reported outcomes in moderate-to-severe plaque psoriasis with scalp involvement: results from a randomized, double-blind, placebo-controlled study of etanercept. J Eur Acad Dermatol Venereol 27:125–128
Thaci D, Daiber W, Boehncke WH, Kaufmann R (2001) Calcipotriol solution for the treatment of scalp psoriasis: evaluation of efficacy, safety and acceptance in 3,396 patients. Dermatology (Basel, Switzerland) 203:153–156
Gattu S, Rashid RM, Wu JJ (2009) 308-nm excimer laser in psoriasis vulgaris, scalp psoriasis, and palmoplantar psoriasis. J Eur Acad Dermatol Venereol 23:36–41
Nishida E, Furuhashi T, Kato H, Kaneko N, Shintani Y, Morita A (2011) Successful treatment of psoriasis vulgaris with targeted narrow-band ultraviolet B therapy using a new flat-type fluorescent lamp. Photodermatol Photoimmunol Photomed 27:248–250
York NR, Jacobe HT (2010) UVA1 phototherapy: a review of mechanism and therapeutic application. Int J Dermatol 49:623–630
Zandi S, Kalia S, Lui H (2012) UVA1 phototherapy: a concise and practical review. Skin Therapy Lett 17:1–4
Roussaki-Schulze AV, Kouskoukis C, Klimi E, Zafiriou E, Galanos A, Rallis E (2005) Calcipotriol monotherapy versus calcipotriol plus UVA1 versus calcipotriol plus narrow-band UVB in the treatment of psoriasis. Drugs Exp Clin Res 31:169–174
Tuchinda C, Kerr HA, Taylor CR et al (2006) UVA1 phototherapy for cutaneous diseases: an experience of 92 cases in the United States. Photodermatol Photoimmunol Photomed 22:247–253
Hofbauer G (2013) Phototherapy and carcinogenesis. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 64:349–353
Keyal U, Bhatta AK, Wang XL (2017) UVA1 a promising approach for scleroderma. Am J Transl Res 9:4280–4287
Morita A, Werfel T, Stege H et al (1997) Evidence that singlet oxygen-induced human T helper cell apoptosis is the basic mechanism of ultraviolet—a radiation phototherapy. J Exp Med 186:1763–1768
Breuckmann F, von Kobyletzki G, Avermaete A, Kreuter A, Altmeyer P (2002) Efficacy of ultraviolet A1 phototherapy on the expression of bcl-2 in atopic dermatitis and cutaneous T-cell lymphoma in vivo: a comparison study. Photodermatol Photoimmunol Photomed 18:217–222
El-Mofty M, Mostafa WZ, Yousef R et al (2014) Broadband ultraviolet a in the treatment of psoriasis vulgaris: a randomized controlled trial. Int J Dermatol 53:1157–1164
This study is supported by the Shanghai Municipal Commission of Health and Family Planning Foundation (Grant No: 201740245).
Conflict of interest
The authors declare that they have no conflict of interest.
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Zhou, J., Yi, X., Li, Y. et al. Efficacy assessment of UVA1 and narrowband UVB for treatment of scalp psoriasis. Lasers Med Sci 33, 1979–1982 (2018). https://doi.org/10.1007/s10103-018-2564-z
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