Promotion of wound healing through low-fluence ablative fractional laser treatment in diabetic mice

  • Han Na Lee
  • Jung Min Bae
  • Bon Cheol Leo Goo
  • Young Min Park
Brief Report


Chronic ulcers are a significant cause of morbidity in diabetic patients, which can greatly affect a patient’s quality of life. While numerous methods have been developed to promote and enhance wound healing in diabetic patients, a convenient, effective treatment for diabetic ulcers has yet to be established. Here, we demonstrate the promotion of wound healing using a low-fluence (2 mJ/spot) ablative fractional laser (AFL) treatment in diabetic mice. Treatment was shown to confer increases in mRNA expression and in protein abundance of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), along with decreases in mRNA expression and protein abundance of transforming growth factor beta (TGF-β). Taken together, these results suggest that low-fluence AFL treatment can be used to promote healing in chronic diabetic wounds.


Diabetics Fractional laser Wound healing Wound repair Regeneration 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  • Han Na Lee
    • 1
  • Jung Min Bae
    • 1
  • Bon Cheol Leo Goo
    • 2
  • Young Min Park
    • 3
  1. 1.Department of Dermatology, St. Vincent’s Hospital, College of MedicineThe Catholic University of KoreaSeoulSouth Korea
  2. 2.Naum ClinicSeoulSouth Korea
  3. 3.Department of Dermatology, Seoul St. Mary’s Hospital, College of MedicineThe Catholic University of KoreaSeoulSouth Korea

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