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Treatment of mucositis with combined 660- and 808-nm-wavelength low-level laser therapy reduced mucositis grade, pain, and use of analgesics: a parallel, single-blind, two-arm controlled study

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Abstract

Oral squamous cell carcinoma (OSCC) is the most frequent oral malignant neoplasia. As consequence of OSCC treatment, oral mucositis (OM) is one of the most common adverse effects of OSCC treatment. Currently, there is no consensus for OM treatment. The purpose of the current study was to test the combination of red and infrared low-level laser therapy (LLLT) for OM treatment. Primary culture of human fibroblast was performed to identify LLLT dose. After laboratory tests, a two-arm parallel, single-blind, controlled study was conducted. The two arms were group 1, both 660- and 808-nm wavelengths (300 J/cm2, 9 J of total energy, 100 mW, spot size 3 mm2), and group 2, only 660-nm wavelength (300 J/cm2, 9 J of total energy, 100 mW, spot size 3 mm2). Both treatments were performed twice a week. Group 1 presented a reduction of mucositis grade in comparison to group 2. Group 1 also presented reduction of analgesics prescription. But no significant differences between groups 1 and 2 were observed according to the pain scale. In conclusion, the current study demonstrated that a combination of red and infrared at a higher dose (300 J/cm2) reduced both oral mucositis grade and analgesics prescription. The effects of the combination of RT and LLLT are unclear and need more studies.

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Acknowledgements

Dr. Guimarães, Dr. Dr. Santos, and Dr. de Paula are research fellows of the CNPq. Dr. Farias is a research fellow of FAPEMIG.

Funding

This study was supported by grants from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and the Fundação de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG).

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Authors and Affiliations

  1. Department of Dentistry, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil

    Raquel Gusmão Soares, Lucyana Conceição Farias, Agna Soares da Silva Menezes, Angeliny Tamiarana Lima Tabosa, Pablo Vinicyus Ferreira Chagas, Alfredo Maurício Batista de Paula & André Luiz Sena Guimarães

  2. Department of Nursy, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, Minas Gerais, Brazil

    Carla Silvana de Oliveira e Silva

  3. Dilson Godinho Hospital, Montes Claros, Minas Gerais, Brazil

    Laís Santiago & André Luiz Sena Guimarães

  4. Institute of Agricultural Sciences, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil

    Sérgio Henrique Sousa Santos

  5. Universidade Estadual de Montes Claros, Laboratório de Pesquisa em Saúde, Hospital Universitário Clemente Faria, 562 Av. Cula Mangabeira Santo Expedito, Montes Claros, Minas Gerais, 39401-001, Brazil

    André Luiz Sena Guimarães

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  1. Raquel Gusmão Soares
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Correspondence to André Luiz Sena Guimarães.

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The authors declare that they have no conflicts of interest.

Ethical approval

Ethical approval for this study was obtained from the relevant Institutional Review Board (48215415.0.0000.5146). The study was also registered in National Clinical Trials (UTN: U1111-1177-9023/67hjmn).

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Soares, R.G., Farias, L.C., da Silva Menezes, A.S. et al. Treatment of mucositis with combined 660- and 808-nm-wavelength low-level laser therapy reduced mucositis grade, pain, and use of analgesics: a parallel, single-blind, two-arm controlled study. Lasers Med Sci 33, 1813–1819 (2018). https://doi.org/10.1007/s10103-018-2549-y

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