Lasers in Medical Science

, Volume 33, Issue 7, pp 1479–1483 | Cite as

Removal of unwanted hair: efficacy, tolerability, and safety of long-pulsed 755-nm alexandrite laser equipped with a sapphire handpiece

  • Steven Paul Nistico
  • Ester Del Duca
  • Francesca Farnetani
  • Stefania Guida
  • Giovanni Pellacani
  • Ali Rajabi-Estarabadi
  • Keyvan Nouri
Original Article


Due to the difference in refraction coefficients between air and the corneal epithelium, irradiation of the skin with a light source can lead to reflection of the energy and its leakage to the skin causes epidermal injury. All of which decreases the efficacy of treatment. We evaluated cooling sapphire handpieces’ efficacy in decreasing pain and epidermal injuries and enhancing the treatment outcome in laser hair removal. A total of 49 patients with Fitzpatrick skin types of II to IV were treated for laser hair removal on face, limbs, inguinal, and axillary areas with pulsed 755-nm alexandrite laser equipped with a sapphire handpiece and the cooling system. Hair counts were performed by two independent observers at the baseline and 3 months after the final treatment. A marked reduction in hair regrowth was noted 3 months after the final treatment in all body locations studied. Clinical hair reduction was observed and fully assessed. There were no serious side effects with an average pain score of 4.6 out of 40. The cooled sapphire cylinder tip has been shown to minimize epidermal injury and reduce the system energy leaks to the skin.


Laser Hair removal Alexandrite 755 nm 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


  1. 1.
    Goldberg DJ (2007) Laser and light-based hair removal: an update. Expert Rev Med Devices 4(2):253–260CrossRefPubMedGoogle Scholar
  2. 2.
    Lorenz S, Brunnberg S, Landthaler M et al (2002) Hair removal with the long pulsed Nd:YAG laser: a prospective study with one year follow-up. Lasers Surg Med 30:127–134CrossRefPubMedGoogle Scholar
  3. 3.
    Gan SD, Graber EM (2013) Laser hair removal: a review. Dermatol Surg 39(6):823–838CrossRefPubMedGoogle Scholar
  4. 4.
    Grunewald S, Bodendorf MO, Zygouris A et al (2014) Long-term efficacy of linear-scanning 808 nm diode laser for hair removal compared to a scanned alexandrite laser. Lasers Surg Med 46(1):13–19CrossRefPubMedGoogle Scholar
  5. 5.
    Drosner M, Photoepilation AM (2005) Guidelines for care from the European Society for Laser Dermatology (ESLD). J Cosmet Laser Ther 7:33–38PubMedGoogle Scholar
  6. 6.
    Davoudi SM, Behnia F, Gorouhi F et al (2008) Comparison of long-pulsed alexandrite and Nd:YAG lasers, individually and in combination, for leg hair reduction: an assessor blinded, randomized trial with 18 months follow-up. Arch Dermatol 144(10):1323–1327CrossRefPubMedGoogle Scholar
  7. 7.
    Toosi P, Sadighha A, Sharifian A et al (2006) A comparison study of the efficacy and side effects of different light sources in hair removal. Lasers Med Sci 21(1):1–4CrossRefPubMedGoogle Scholar
  8. 8.
    Freedman BM, Earley RV (2000) A structured treatment protocol improves results with laser hair removal. J Cutan Laser Ther 2:131–135CrossRefPubMedGoogle Scholar
  9. 9.
    Tierney EP, Goldberg DJ (2009) Laser hair removal pearls. J Cosmet Laser Ther 10(1):17–23Google Scholar
  10. 10.
    Goldberg DJ (2006) Laser complications: hair removal. J Cosmet Laser Ther 8:197–202CrossRefPubMedGoogle Scholar
  11. 11.
    Kutlubay Z (2009) Alexandrite laser hair removal results in 2359 patients: a Turkish experience. J Cosmet Laser Ther 11:85–93CrossRefPubMedGoogle Scholar
  12. 12.
    Rasheed AI (2009) Uncommonly reported side effects of hair removal by long pulsed alexandrite laser. J Cosmet Dermatol 8:267–274CrossRefPubMedGoogle Scholar
  13. 13.
    Chuang GS et al (2016) Gaseous and particulate content of laser hair removal plume. JAMA Dermatol 152(12):1320–1326CrossRefPubMedGoogle Scholar
  14. 14.
    Ross EV, Chuang GS, Ortiz AE (2017) Airborne particulate concentration during laser hair removal: a comparison between cold sapphire with aqueous gel and cryogen skin cooling. Lasers Surg Med.
  15. 15.
    Finkel B, Eliezri YD, Waldman A, Slatkine M (1997) Pulsed alexandrite laser technology for noninvasive hair removal. J Clin Laser Med Surg 15:225–229PubMedGoogle Scholar
  16. 16.
    Ibrahimi OA, Avram MM, Hanke CW, Kilmer SL, Anderson RR (2011) Laser hair removal. Dermatol Ther 24:94–107CrossRefPubMedGoogle Scholar
  17. 17.
    Serrano-Grau P, Campo-Voegeli A, Fotoepilacion RD (2009) Actas Dermosifiliogr 100:351–361CrossRefPubMedGoogle Scholar
  18. 18.
    Haedersdal M, Beerwerth F, Nash JF (2011) Laser and intense pulsed light hair removal technologies: from professional to home use. Br J Dermatol 165:31–36CrossRefPubMedGoogle Scholar
  19. 19.
    Nelson JS, Majaron B, Kelly KM (2000) Active skin cooling in conjunction with laser dermatologic surgery. Semin Cutan Med Surg 19(4):253–266CrossRefPubMedGoogle Scholar
  20. 20.
    Khan MA, Javed AA, Govindan et al (2016) Control of hair growth using long-pulsed alexandrite laser is an efficient and cost-effective therapy for patients suffering from recurrent pilonidal disease. Lasers Med Sci 31(5):857–862CrossRefPubMedGoogle Scholar
  21. 21.
    Jasterzbski TJ, Schwartz RA (2015) Pseudofolliculitis cutis: a vexing disorder of hair growth. Br J Dermatol 172(4):878–884CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  • Steven Paul Nistico
    • 1
  • Ester Del Duca
    • 2
  • Francesca Farnetani
    • 3
  • Stefania Guida
    • 3
  • Giovanni Pellacani
    • 3
  • Ali Rajabi-Estarabadi
    • 4
  • Keyvan Nouri
    • 4
  1. 1.Department of Health SciencesUniversity of Catanzaro “Magna Graecia”CatanzaroItaly
  2. 2.University of Tor VergataRomeItaly
  3. 3.Department of DermatologyUniversity of ModenaModenaItaly
  4. 4.Department of Dermatology and Cutaneous SurgeryUniversity of Miami Miller School of MedicineMiamiUSA

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