Lasers in Medical Science

, Volume 34, Issue 6, pp 1099–1105 | Cite as

Clinical efficacy of laser combined with menstrual regulation in the treatment of female melasma: a retrospective study

  • Yu Jin
  • Wenbo Jiang
  • Yonghui Yao
  • Huang HuangEmail author
  • Jinlong HuangEmail author
Original Article


The aim of this study was to evaluate the clinical efficacy of using a Medlite C6 Q-switch Nd:YAG laser combined with menstrual regulation–based traditional Chinese medicine (TCM) in the treatment of female melasma. Forty cases of female patients with melasma, who were treated between December 2013 and December 2015 at the Jiangsu Provincial Hospital of Traditional Chinese Medicine, were reviewed retrospectively. Twenty patients received Q-switch Nd:YAG 1064 nm laser treatments combined with menstrual regulation treatments (experimental group), and 20 patients were treated only with the laser (control group). All treatments lasted for 6 months. The patients’ faces were photographed before, immediately, and 6 months after treatment. The therapeutic efficacy was assessed by the reduction in the Melasma Area and Severity Index (MASI) score and the total skin damage score, and this was then compared between the two groups. Immediately and 6 months after the treatment, both the MASI and total skin damage scores in the experimental group were significantly lower compared to those in the control group (P < 0.001). The experimental group had significantly higher basic recovery and effectiveness rates than the control group (P = 0.020 and P = 0.008, respectively) and had a significantly lower invalidity rate (P < 0.001). Results from Medlite C6 Q-switch Nd:YAG laser treatment combined with menstrual regulation are superior than those obtained using only a laser for the treatment of female melasma.


Female Melasma Menstrual regulation Laser Efficacy 


Compliance with ethical standards

Ethics approval

This study was approved by the Ethics Committee of the Jiangsu Provincial Hospital of Traditional Chinese Medicine. All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all the participants included in the study.

Competing interests

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Plastic SurgeryJiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of TCMNanjingChina
  2. 2.Cardiovascular Medicine DepartmentSuqian Hospital of TCMSuqianPeople’s Republic of China
  3. 3.General Surgery DepartmentNanjing Pukou District Hospital of TCMNanjingPeople’s Republic of China
  4. 4.College of Basic MedicineNanjing University of Chinese MedicineNanjingChina

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