Lasers in Medical Science

, Volume 33, Issue 3, pp 603–607 | Cite as

Effect of low-level laser therapy on the healing process of donor site in patients with grade 3 burn ulcer after skin graft surgery (a randomized clinical trial)

  • Reza Vaghardoost
  • Mahnoush Momeni
  • Nooshafarin Kazemikhoo
  • Soheila Mokmeli
  • Mostafa Dahmardehei
  • Fereshteh Ansari
  • Mohammad Ali Nilforoushzadeh
  • Parisa Sabr joo
  • Sara Mey Abadi
  • Soheila Naderi Gharagheshlagh
  • Saeed Sassani
Original Article


Skin graft is a standard therapeutic technique in patients with deep ulcers, but managing donor site after grafting is very important. Although several modern dressings are available to enhance the comfort of donor site, using techniques that accelerate wound healing may enhance patient satisfaction. Low-level laser therapy (LLLT) has been used in several medical fields, including healing of diabetic, surgical, and pressure ulcers, but there is not any report of using this method for healing of donor site in burn patients. The protocols and informed consent were reviewed according to Medical Ethics Board of Shahid Beheshti University of Medical Sciences (IR.SBMU.REC.1394.363) and Iranian Registry of Clinical Trials (IRCT2016020226069N2). Eighteen donor sites in 11 patients with grade 3 burn ulcer were selected. Donor areas were divided into 2 parts, for laser irradiation and control randomly. Laser area was irradiated by a red, 655-nm laser light, 150 mW, 2 J/cm2, on days 0 (immediately after surgery), 3, 5, and 7. Dressing and other therapeutic care for both sites were the same. The patients and the person who analyzed the results were blinded. The size of donor site reduced in both groups during the 7-day study period (P < 0.01) and this reduction was significantly greater in the laser group (P = 0.01). In the present study, for the first time, we evaluate the effects of LLLT on the healing process of donor site in burn patients. The results showed that local irradiation of red laser accelerates wound healing process significantly.


Low-level laser therapy Skin graft Wound healing 



We extend our gratitude to the staff of Motahari Burn Center for their assistance.

Compliance with ethical standards

The protocols and informed consent were reviewed according to Medical Ethics Board of Shahid Beheshti University of Medical Sciences (IR.SBMU.REC.1394.363) and Iranian Registry of Clinical Trials (IRCT2016020226069N2).

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  • Reza Vaghardoost
    • 1
  • Mahnoush Momeni
    • 1
  • Nooshafarin Kazemikhoo
    • 2
  • Soheila Mokmeli
    • 3
  • Mostafa Dahmardehei
    • 1
  • Fereshteh Ansari
    • 4
  • Mohammad Ali Nilforoushzadeh
    • 2
  • Parisa Sabr joo
    • 1
  • Sara Mey Abadi
    • 1
  • Soheila Naderi Gharagheshlagh
    • 1
  • Saeed Sassani
    • 5
  1. 1.Burn Research center, Department of Plastic and Reconstructive SurgeryIran University of Medical SciencesTehranIran
  2. 2.Skin and Stem Cell Research CenterTehran University of Medical SciencesTehranIran
  3. 3.Canadian Optic and Laser CenterVictoriaCanada
  4. 4.Laser Application in Medical Sciences Research CenterShahid Beheshti University of Medical SciencesTehranIran
  5. 5.Al Nasr Sport Club Medical SectionDubaiUnited Arab Emirates

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