Lasers in Medical Science

, Volume 33, Issue 3, pp 461–467 | Cite as

Efficacy of long pulse Nd:YAG laser versus fractional Er:YAG laser in the treatment of hand wrinkles

  • Reza M. Robati
  • Elmira Asadi
  • Anoosh Shafiee
  • Nastaran Namazi
  • Atefeh Talebi
Original Article


There are different modalities for hand rejuvenation. Fractional Er:YAG laser and long pulse Nd:YAG laser were introduced for treating hand wrinkles. We plan to compare fractional Er:YAG laser and long pulse Nd:YAG laser in a randomized controlled double-blind design with multiple sessions and larger sample size in comparison with previous studies. Thirty-three participants with hand wrinkles entered this study. They were randomly allocated to undergo three monthly laser treatments on each hand, one with a fractional Er:YAG laser and the other with a long pulse Nd:YAG laser. The evaluations included assessment of clinical improvement determined by two independent dermatologists not enrolled in the treatment along with measuring skin biomechanical property of hands using a sensitive biometrologic device with the assessment of cutaneous resonance running time (CRRT). Moreover, potential side effects and patients’ satisfaction have been documented at baseline, 1 month after each treatment, and 3 months after the final treatment session. Clinical evaluation revealed both modalities significantly reduce hand wrinkles (p value < 0.05), with no significant difference between two lasers. Mean CRRT values also decreased significantly after the laser treatment compared to those of the baseline in both laser groups. There was no serious persistent side effect after both laser treatments. Both fractional Er:YAG and long pulse Nd:YAG lasers show substantial clinical improvement of hand skin wrinkles with no serious side effects. However, combination treatment by these lasers along with the other modalities such as fat transfer could lead to better outcomes in hand rejuvenation. Trial registration: IRCT2016032020468N4


Erbium:YAG laser Hand rejuvenation ND:YAG laser Skin aging 


Role of funding source

This study has been funded by Skin Research Center, Shahid Beheshti University of Medical Sciences with grant number of 94/141.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interests.

Ethical approval

This study was approved by the Ethical Committee of Shahid Beheshti University of Medical Sciences with number of Ir.sbmu.ram.rec.1394.414. This project was performed according to the principles of the Declaration of Helsinki. The protocol was approved by the Iranian Registry of Clinical Trials (IRCT ID2016032020468N4).

Informed consent

All of the subjects signed a written informed consent after explanation of the procedure.


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Copyright information

© Springer-Verlag London Ltd. 2017

Authors and Affiliations

  1. 1.Skin Research CenterShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Colorectal Research CenterIran University of Medical SciencesTehranIran

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