Skip to main content

Advertisement

SpringerLink
Log in

Effect of photodynamic therapy with malachite green on non-surgical periodontal treatment in HIV patients: a pilot split-mouth study

  • Brief Report
  • Published:
Lasers in Medical Science Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Reznik DA (2005) Oral manifestations of HIV disease. Top HIV Med 13:143–8

    PubMed  Google Scholar 

  2. Coogan MM, Greenspan J, Challacombe SJ (2005) Oral lesions in infection with human immunodeficiency virus. Bull World Health Organ 83:700–6

    PubMed  PubMed Central  Google Scholar 

  3. Alpagot T, Duzgunes N, Wolff LF, Lee A (2004) Risk factors for periodontitis in HIV patients. J Periodontal Res 39:149–57

    Article  PubMed  Google Scholar 

  4. Yeung SC, Stewart GJ, Cooper DA, Sindhusake D (1993) Progression of periodontal disease in HIV seropositive patients. J Periodontol 64:651–7

    Article  CAS  PubMed  Google Scholar 

  5. Patel M, Coogan M, Galpin JS (2003) Periodontal pathogens in subgingival plaque of HIV-positive subjects with chronic periodontitis. Oral Microbiol Immunol 18:199–201

    Article  CAS  PubMed  Google Scholar 

  6. Rams TE, Andriolo M Jr, Feik D, Abel SN, McGivern TM, Slots J (1991) Microbiological study of HIV-related periodontitis. J Periodontol 62:74–81

    Article  CAS  PubMed  Google Scholar 

  7. Sanz M, Lau L, Herrera D, Morillo JM, Silva A (2004) Methods of detection of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Tannerella forsythensis in periodontal microbiology, with special emphasis on advanced molecular techniques: a review. J Clin Periodontol 31:1034–47

    Article  CAS  PubMed  Google Scholar 

  8. Anderson GB, Palmer JA, Bye FL, Smith BA, Caffesse RG (1996) Effectiveness of subgingival scaling and root planing: single versus multiple episodes of instrumentation. J Periodontol 67:367–73

    Article  CAS  PubMed  Google Scholar 

  9. Kornman KS (1993) Controlled-release local delivery antimicrobials in periodontics: prospects for the future. J Periodontol 64:782–91

    Article  CAS  PubMed  Google Scholar 

  10. Garcia Canas P, Khouly I, Sanz J, Loomer PM (2015) Effectiveness of systemic antimicrobial therapy in combination with scaling and root planing in the treatment of periodontitis: a systematic review. J Am Dent Assoc 146:150–63

    Article  PubMed  Google Scholar 

  11. Demidova TN, Hamblin MR (2005) Effect of cell-photosensitizer binding and cell density on microbial photoinactivation. Antimicrob Agents Chemother 49:2329–35

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Kowaltowski AJ, Turin J, Indig GL, Vercesi AE (1999) Mitochondrial effects of triarylmethane dyes. J Bioenerg Biomembr 31:581–90

    Article  CAS  PubMed  Google Scholar 

  13. Yamaoka K, Sasai R (2000) Pulsed electric linear dichroism of triphenylmethane dyes adsorbed on montmorillonite K10 in aqueous media. J Colloid Interface Sci 225:82–93

    Article  CAS  PubMed  Google Scholar 

  14. Eke PI, Page RC, Wei L, Thornton-Evans G, Genco RJ (2012) Update of the case definitions for population-based surveillance of periodontitis. J Periodontol 83:1449–54

    Article  PubMed  Google Scholar 

  15. Noro Filho GA, Casarin RC, Casati MZ, Giovani EM (2012) PDT in non-surgical treatment of periodontitis in HIV patients: a split-mouth, randomized clinical trial. Lasers Surg Med 44:296–302

    Article  PubMed  Google Scholar 

  16. Casarin RC, Ribeiro Edel P, Mariano FS, Nociti FH Jr, Casati MZ, Goncalves RB (2010) Levels of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, inflammatory cytokines and species-specific immunoglobulin G in generalized aggressive and chronic periodontitis. J Periodontal Res 45:635–42

    Article  CAS  PubMed  Google Scholar 

  17. Goncalves LS, Soares Ferreira SM, Souza CO, Souto R, Colombo AP (2007) Clinical and microbiological profiles of human immunodeficiency virus (HIV)-seropositive Brazilians undergoing highly active antiretroviral therapy and HIV-seronegative Brazilians with chronic periodontitis. J Periodontol 78:87–96

    Article  PubMed  Google Scholar 

  18. Correa MG, Oliveira DH, Saraceni CH, Ribeiro FV, Pimentel SP, Cirano FR et al (2015) Short-term microbiological effects of photodynamic therapy in non-surgical periodontal treatment of residual pockets: a split-mouth RCT. Lasers Surg Med

  19. Prates RA, Yamada AM Jr, Suzuki LC, Eiko Hashimoto MC, Cai S, Gouw-Soares S et al (2007) Bactericidal effect of malachite green and red laser on Actinobacillus actinomycetemcomitans. J Photochem Photobiol B 86:70–6

    Article  CAS  PubMed  Google Scholar 

  20. Rolim JP, de-Melo MA, Guedes SF, Albuquerque-Filho FB, de Souza JR, Nogueira NA et al (2012) The antimicrobial activity of photodynamic therapy against Streptococcus mutans using different photosensitizers. J Photochem Photobiol B 106:40–6

    Article  CAS  PubMed  Google Scholar 

  21. Polansky R, Haas M, Heschl A, Wimmer G (2009) Clinical effectiveness of photodynamic therapy in the treatment of periodontitis. J Clin Periodontol 36:575–80

    Article  PubMed  Google Scholar 

  22. Al-Zahrani MS, Austah ON (2011) Photodynamic therapy as an adjunctive to scaling and root planing in treatment of chronic periodontitis in smokers. Saudi Med J 32:1183–8

    PubMed  Google Scholar 

  23. Andersen R, Loebel N, Hammond D, Wilson M (2007) Treatment of periodontal disease by photodisinfection compared to scaling and root planing. J Clin Dent 18:34–8

    PubMed  Google Scholar 

  24. Braun A, Dehn C, Krause F, Jepsen S (2008) Short-term clinical effects of adjunctive antimicrobial photodynamic therapy in periodontal treatment: a randomized clinical trial. J Clin Periodontol 35:877–84

    Article  CAS  PubMed  Google Scholar 

  25. Campos GN, Pimentel SP, Ribeiro FV, Casarin RC, Cirano FR, Saraceni CH et al (2013) The adjunctive effect of photodynamic therapy for residual pockets in single-rooted teeth: a randomized controlled clinical trial. Lasers Med Sci 28:317–24

    Article  PubMed  Google Scholar 

  26. Atieh MA (2010) Photodynamic therapy as an adjunctive treatment for chronic periodontitis: a meta-analysis. Lasers Med Sci 25:605–13

    Article  PubMed  Google Scholar 

  27. Silva EJ, Coutinho-Filho WP, Andrade AO, Herrera DR, Coutinho-Filho TS, Krebs RL (2014) Evaluation of photodynamic therapy using a diode laser and different photosensitizers against enterococcus faecalis. Acta Odontol Latinoam 27:63–5

    PubMed  Google Scholar 

  28. Thiese MS (2014) Observational and interventional study design types; an overview. Biochem Med (Zagreb) 24:199–210

    Article  Google Scholar 

  29. Sgolastra F, Petrucci A, Severino M, Graziani F, Gatto R, Monaco A (2013) Adjunctive photodynamic therapy to non-surgical treatment of chronic periodontitis: a systematic review and meta-analysis. J Clin Periodontol 40:514–26

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Oral Radiology, School of Dentistry, University of São Paulo, Av. Lineu Prestes, 2227, 05508-000, Sao Paulo, SP, Brazil

    Daniela M. R. A. Salgado, Gilberto A. Noro-Filho, Arthur R. G. Cortes, Emiko S. Arita & Claudio Costa

  2. Department of Special Patients, School of Dentistry, Paulista University, São Paulo, Brazil

    Renato C. V. Casarin & Elcio M. Giovani

Authors
  1. Daniela M. R. A. Salgado
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gilberto A. Noro-Filho
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Arthur R. G. Cortes
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Emiko S. Arita
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Renato C. V. Casarin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Claudio Costa
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Elcio M. Giovani
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Arthur R. G. Cortes.

Ethics declarations

Ethical approval

Ethical approval was obtained from the ethics committee of the Paulista University (protocol number 408/11 CEP/ICS/UNIP).

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

All subjects willing to participate in this study signed an informed consent form.

Role of funding source

This work was partially funded by the Coordination for the Improvement of Higher Level or Education Personnel (CAPES—Brazil).

Additional information

Summary

Adjunctive periodontal treatment with PDT using malachite green leads to significant reduction of microbiological levels of periodontal pathogens in HIV patients.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Salgado, D.M.R.A., Noro-Filho, G.A., Cortes, A.R.G. et al. Effect of photodynamic therapy with malachite green on non-surgical periodontal treatment in HIV patients: a pilot split-mouth study. Lasers Med Sci 32, 1213–1217 (2017). https://doi.org/10.1007/s10103-016-2083-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10103-016-2083-8

Keywords

Search

Navigation