Lasers in Medical Science

, Volume 31, Issue 9, pp 1907–1913 | Cite as

Low-intensity laser (660 nm) on sternotomy healing in patients who underwent coronary artery bypass graft: a randomized, double-blind study

  • Gilderlene Alves FernandesEmail author
  • Andréa Conceição Gomes Lima
  • Isabel Clarisse Albuquerque Gonzaga
  • Raimundo de Barros AraújoJr.
  • Rauirys Alencar de Oliveira
  • Renata Amadei Nicolau
Original Article


The aim of this study was to analyze the healing effects of low-level laser therapy (LLLT) on the longitudinal sternotomy incisions of patients who underwent coronary artery bypass graft (CABG). The volunteers were randomized into three groups of equal size (n = 30): control, placebo, and laser (λ = 660 nm and spatial average energy fluency [SAEF] = 1.06 J/cm2). The patients in the laser group underwent irradiation on postoperative days 2, 4, 6, and 8, and their sternotomy incisions were photographed immediately after the surgery and 8 days later for analysis. Three researchers who were blinded to the patient treatment groups analyzed the incision photographs to assess hyperemia and wound closure on the day of hospital discharge (eighth postoperative day). The sternotomy incisions in the LLLT group demonstrated less hyperemia, incisional bleeding, and dehiscence (p ≤ 0.005).


Coronary artery bypass graft Low-intensity laser therapy Sternotomy Incision healing 


Compliance with ethical standards

All of the subjects signed a written declaration of informed consent. The protocol for this study was approved by the local research ethics committee CAAE 0127.0.043.000-11, and it was registered at the Brazilian Clinical Trial Registry and the International Clinical Trials Registry Platform of the World Health Organization under RBR-38wgx6 and Universal Trial Number U1111-1128-9666.


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Copyright information

© Springer-Verlag London 2016

Authors and Affiliations

  • Gilderlene Alves Fernandes
    • 1
    • 2
    • 6
    Email author
  • Andréa Conceição Gomes Lima
    • 1
    • 3
  • Isabel Clarisse Albuquerque Gonzaga
    • 1
    • 2
  • Raimundo de Barros AraújoJr.
    • 4
  • Rauirys Alencar de Oliveira
    • 5
  • Renata Amadei Nicolau
    • 1
  1. 1.Lasertherapy and Photobiology Center, Research and Development Institute, IP&DUniversidade do Vale do Paraíba, UNIVAPSão PauloBrazil
  2. 2.Uninovafapi CollegeTeresinaBrazil
  3. 3.University of Piauí State (UESPI)TeresinaBrazil
  4. 4.Cardiac Surgery DepartmentSanta Maria HospitalTeresinaBrazil
  5. 5.Uninovafapi College and University of Piauí State (UESPI)TeresinaBrazil
  6. 6.TeresinaBrazil

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