Low-intensity laser (660 nm) on sternotomy healing in patients who underwent coronary artery bypass graft: a randomized, double-blind study
The aim of this study was to analyze the healing effects of low-level laser therapy (LLLT) on the longitudinal sternotomy incisions of patients who underwent coronary artery bypass graft (CABG). The volunteers were randomized into three groups of equal size (n = 30): control, placebo, and laser (λ = 660 nm and spatial average energy fluency [SAEF] = 1.06 J/cm2). The patients in the laser group underwent irradiation on postoperative days 2, 4, 6, and 8, and their sternotomy incisions were photographed immediately after the surgery and 8 days later for analysis. Three researchers who were blinded to the patient treatment groups analyzed the incision photographs to assess hyperemia and wound closure on the day of hospital discharge (eighth postoperative day). The sternotomy incisions in the LLLT group demonstrated less hyperemia, incisional bleeding, and dehiscence (p ≤ 0.005).
KeywordsCoronary artery bypass graft Low-intensity laser therapy Sternotomy Incision healing
Compliance with ethical standards
All of the subjects signed a written declaration of informed consent. The protocol for this study was approved by the local research ethics committee CAAE 0127.0.043.000-11, and it was registered at the Brazilian Clinical Trial Registry and the International Clinical Trials Registry Platform of the World Health Organization under RBR-38wgx6 and Universal Trial Number U1111-1128-9666.
- 2.Padua A De, Favarato D (2012) Original article mortality due to cardiovascular diseases in Brazil and in the Metropolitan Region of São Paulo : A 2011 Update. Arq Bras Cardiol 2:755–761. doi: 10.1590/S0066-782X2012005000061
- 6.Oliveira R de A de, Matos AF, Regina N, et al. (2013) Low-intensity laser therapy and led (light emitting diode) therapy in mechanical resistance of Rattus norvegicus chest inscision with implant of steel wire for sternal suture. Brazilian J Biomed Eng 29:166–174. doi: rbeb.2013.016Google Scholar
- 7.Carvalho KDC, Nicolau RA, Luis A et al (2010) Estudo da resistência cicatricial cutânea de ratos tratados com fototerapia a laser. Conscientiae saúde 9:179–186Google Scholar
- 10.Souza NHC, Marcondes PT, Albertini R et al (2014) Low-level laser therapy suppresses the oxidative stress-induced glucocorticoids resistance in U937 cells: relevance to cytokine secretion and histone deacetylase in alveolar macrophages. J Photochem Photobiol B 130:327–336. doi: 10.1016/j.jphotobiol.2013.12.010 CrossRefPubMedGoogle Scholar
- 16.De Baptista IM C, Chavantes MC, De Dallan LA O, Stolf NAG (2009) Laser de Baixa Intensidade: Nova Tecnologia para os Enfermeiros na Cicatrizaçao Pós-Esternotomia. Rev da Soc Cardiol do Estado São Paulo 19:3–8Google Scholar
- 24.Fukuda Y, Ito Y, Azumi H, et al. (2002) Cell death and proliferation in Nd-YAG laser, electrocautery, and scalpel wounds on mice skin. 28:106–118.Google Scholar