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Can we predict the outcome of 595-nm wavelength pulsed dye laser therapy on capillary vascular malformations from the first beginning: a pilot study of efficacy co-related factors in 686 Chinese patients

Lasers in Medical Science volume 30, pages 1041–1046 (2015)Cite this article

Abstract

Currently, there are no standardized, objective, and clinically applicable methods to predict the outcome of pulsed dye laser (PDL) therapy on capillary vascular malformation (CVM) patients. The introduction of a method that can predict the outcome prior to treatment will be valuable for both the patients and the doctors. In this study, the authors treated CVM with 595-nm wavelength PDL in Chinese patients (n = 686) and analyzed the efficacy of treatment and complications retrospectively in a 5-year period. Nearly 18 % of patients (n = 122) had 76 % or more clearing of lesions; over 52 % of patients (n = 360) had more than 50 % of clearing. The lesions in head and neck region had the best effective rate (58.3 %), followed by trunk (42.9 %) and extremities (35.6 %). The efficacy of PDL therapy is related to age, type, and location of lesions. Fifty-seven patients (8.3 %) had complications, including 2.0 % blistering (n = 14), 4.5 % hyperpigmentation (n = 31), 1.3 % hypopigmentation (n = 9), and 0.4 % hypertrophic scarring (n = 3). Based on these preliminary data, the authors established a standardized, objective, and clinically applicable equation that may be applied to predict the efficacy of 595 nm PDL therapy on a newly diagnosed Chinese CVM patients based on the age, type, and location of lesions.

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Conflict of interest

The authors have no conflicts of interest to declare and no funding was received.

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Affiliations

  1. Division of Plastic and Reconstructive Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China

    Xiangxia Liu & Ruixi Zeng

  2. Department of Aesthetic and Laser Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China

    Xiangxia Liu, Yanfang Fan, Ruixi Zeng, Guangling Cao, Mukai Chen, Wenna Chen & Jinming Tang

  3. Department of Radiology, Guangdong Provincial Hospital of Chinese Traditional Medicine, Guangzhou, 510120, China

    Jiexin Huang

  4. Department of Dermatology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China

    Guangling Cao, Mukai Chen & Wenna Chen

  5. Division of Burn Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China

    Jinming Tang

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  1. Xiangxia Liu
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  2. Yanfang Fan
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  3. Jiexin Huang
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Correspondence to Xiangxia Liu.

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Liu, X., Fan, Y., Huang, J. et al. Can we predict the outcome of 595-nm wavelength pulsed dye laser therapy on capillary vascular malformations from the first beginning: a pilot study of efficacy co-related factors in 686 Chinese patients. Lasers Med Sci 30, 1041–1046 (2015). https://doi.org/10.1007/s10103-014-1695-0

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  • DOI: https://doi.org/10.1007/s10103-014-1695-0

Keywords

  • Capillary vascular malformations
  • Pulsed dye laser
  • Efficacy
  • Prediction