Abstract
The aim of this study was to investigate the autonomic responses and central manifestations by peripheral FIR stimulation. Ten subjects (mean ± SD age 26.2 ± 3.52 years) received FIR stimulation at left median nerve territory for 40 min. Electrocardiograph was continuously recorded and heart rate variability (HRV) were analyzed. By using a 3 T-MRI scanner, three sessions of resting-state functional magnetic resonance images (fMRI) were acquired, namely, before (baseline-FIR), immediately after (IA-FIR) and 15 min after FIR was turned off (Post-FIR). The fractional amplitude of low-frequency (0.01-0.08 Hz) fluctuation (fALFF) of each session to evaluate the intensity of resting-brain activity in each session was analyzed. Our results showed that FIR stimulation induced significant HRV responses such as an increasing trend of nLF and LF/HF ratio, while FIR increased fALFF in right superior front gyrus, middle frontal gyrus and decreased the resting brain activity at fusiform gyrus, extrastriae cortex, inferior temporal gyrus and middle temporal gyrus, especially 15 min after FIR was turned off. We conclude that the central manifestation and the autonomic responses are prominent during and after FIR stimulation, which provide important mechanistic explanation on human disorder treated by such energy medicine.
Similar content being viewed by others
Abbreviations
- FIR:
-
Far-infrared radiation
- HRV:
-
Heart rate variability
- fMRI:
-
Functional magnetic resonance imaging
- fALFF:
-
Fractional amplitude of low-frequency fluctuation
References
Baxter GD, Bleakley C, McDonough S (2008) Clinical effectiveness of laser acupuncture: a systematic review. J Acupunct Meridian Stud 1:65–82
Bjordal JM, Lopes-Martins RA, Joensen J, Couppe C, Ljunggren AE et al (2008) A systematic review with procedural assessments and meta-analysis of low level laser therapy in lateral elbow tendinopathy (tennis elbow). BMC Musculoskelet Disord 9:75
Lin CC, Chang CF, Lai MY, Chen TW, Lee PC et al (2007) Far-infrared therapy: a novel treatment to improve access blood flow and unassisted patency of arteriovenous fistula in hemodialysis patients. J Am Soc Nephrol 18:985–992
Miyata M, Kihara T, Kubozono T, Ikeda Y, Shinsato T et al (2008) Beneficial effects of Waon therapy on patients with chronic heart failure: results of a prospective multicenter study. J Cardiol 52:79–85
Yu SY, Chiu JH, Yang SD, Hsu YC, Lui WY et al (2006) Biological effect of far-infrared therapy on increasing skin microcirculation in rats. Photodermatol Photoimmunol Photomed 22:78–86
Akasaki Y, Miyata M, Eto H, Shirasawa T, Hamada N et al (2006) Repeated thermal therapy up-regulates endothelial nitric oxide synthase and augments angiogenesis in a mouse model of hindlimb ischemia. Circ J 70:463–470
Lewith GT, White PJ, Pariente J (2005) Investigating acupuncture using brain imaging techniques: the current state of play. Evid Based Complement Alternat Med 2:315–319
Campbell A (2006) Point specificity of acupuncture in the light of recent clinical and imaging studies. Acupunct Med 24:118–122
Wu MT, Sheen JM, Chuang KH, Yang P, Chin SL et al (2002) Neuronal specificity of acupuncture response: a fMRI study with electroacupuncture. Neuroimage 16:1028–1037
Hsieh JC, Tu CH, Chen FP, Chen MC, Yeh TC et al (2001) Activation of the hypothalamus characterizes the acupuncture stimulation at the analgesic point in human: a positron emission tomography study. Neurosci Lett 307:105–108
Hui KKS, Nixon EE, Vangel MG, Liu J, Marina O et al (2007) Characterization of the “deqi” response in acupuncture. BMC Complement Alternat Med 7:33
Ho TJ, Duann JR, Chen CM, Chen JH, Shen WC et al (2008) Carryover effects alter FMRI statistical analysis in an acupuncture study. Am J Chin Med 36:55–70
Fox MD, Raichle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8:700–711
Biswal B, Zerrin Yetkin F, Haughton VM, Hyde JS (1995) Functional connectivity in the motor cortex of resting human brain using echo-planar mri. Magn Reson Med 34:537–541
Wang K, Jiang T, Yu C, Tian L, Li J et al (2007) Spontaneous activity associated with primary visual cortex: a resting-state fmri study. Cereb Cortex 18:697–704
Buckner RL, Andrews-Hanna JR, Schacter DL (2008) The brain’s default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci 1124:1–38
Franco AR, Pritchard A, Calhoun VD, Mayer AR (2009) Interrater and intermethod reliability of default mode network selection. Hum Brain Mapp 30:2293–2303
Greicius M, Flores B, Menon V, Glover G, Solvason H et al (2007) Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus. Biol Psychiatry 62:429–437
Baliki MN, Geha PY, Apkarian AV, Chialvo DR (2008) Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics. J Neurosci 28:1398–1403
Loggia ML, Berna C, Kim J, Cahalan CM, Gollub RL et al (2013) Disrupted brain circuitry for pain-related reward/punishment in fibromyalgia. Arthritis Rheum
Kuo CD, Chen GY (1998) Heart rate variability standards. Circulation 98:1589–1590
(1996) Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93:1043–1065
Terashima K, Mikami A, Tachibana N, Kumano-Go T, Teshima Y et al (2004) Sleep characteristics of menopausal insomnia: a polysomnographic study. Psychiatry Clin Neurosci 58:179–185
Chen CJ, Kuo TB, Tseng YJ, Yang CC (2009) Combined cardiac sympathetic excitation and vagal impairment in patients with non-organic erectile dysfunction. Clin Neurophysiol 120:348–352
Kung YY, Yang CC, Chiu JH, Kuo TB (2011) The relationship of subjective sleep quality and cardiac autonomic nervous system in postmenopausal women with insomnia under auricular acupressure. Menopause 18:638–645
Yan C, Zang Y (2010) DPARSF: a MATLAB toolbox for “pipeline” data analysis of resting-state fMRI. Front Syst Neurosci 5:12
Zou Q-H, Zhu C-Z, Yang Y, Zuo X-N, Long X-Y et al (2008) An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI: fractional ALFF. J Neurosci Methods 172:137–141
Lin CC, Liu XM, Peyton K, Wang H, Yang WC et al (2008) Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1. Arterioscler Thromb Vasc Biol 28:739–745
Hsu YH, Chen YC, Chen TH, Sue YM, Cheng TH et al (2012) Far-infrared therapy induces the nuclear translocation of PLZF which inhibits VEGF-induced proliferation in human umbilical vein endothelial cells. PLoS One 7:e30674
Beckmann CF, DeLuca M, Devlin JT, Smith SM (2005) Investigations into resting-state connectivity using independent component analysis. Phil Trans R Soc B Biol Sci 360:1001–1013
Van den Heuvel MP, Hulshoff Pol HE (2010) Exploring the brain network: a review on resting-state fMRI functional connectivity. Eur Neuropsychopharmacol 20:519–534
Fried I, Wilson CL, MacDonald KA, Behnke EJ (1998) Electric current stimulates laughter. Nature 391:650
Goldberg II, Harel M, Malach R (2006) When the brain loses its self: prefrontal inactivation during sensorimotor processing. Neuron 50:329–339
Muehlhan M, Lueken U, Siegert J, Wittchen HU, Smolka MN et al (2013) Enhanced sympathetic arousal in response to FMRI scanning correlates with task induced activations and deactivations. PLoS One 8:e72576
Acknowledgments
We are indebted to the Laboratory of Integrated Brain Research, Department of Medical Research and Education, Taipei Veterans General Hospital, Taiwan, Republic of China, for their excellent comments and resources. We acknowledge MR support from National Yang-Ming University, Taiwan, which is in part supported by the MOE plan for the top university.
Competing interest
The authors have no competing interest.
Authors’ contributions
Lin YJ conducted the studies, analyzed the data, and wrote the manuscript. Chiu JH supervised Dr. Lin YJ and designed the study. Hsieh JC assisted the study design while KungYY, Kuo WJ, Niddam DM, Chou CC, Cheng CM, and Yeh TC provided facilities and helped to analyze the data.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Lin, YJ., Kung, YY., Kuo, WJ. et al. Effects of far-infrared radiation on heart rate variability and central manifestations in healthy subjects: a resting-fMRI study. Lasers Med Sci 30, 295–301 (2015). https://doi.org/10.1007/s10103-014-1662-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10103-014-1662-9