The effect of low-level laser therapy on knee osteoarthritis: prospective, descriptive study



Osteoarthritis (OA) is one of the most common joint disorders in the elderly which could be associated with considerable physical disability.

Patients and methods

In a descriptive, prospective study, 33 patients enrolled in the study from which 15 people were excluded due to incomplete course of treatment, leaving the total number of 18 patients with knee osteoarthritis. Gal-Al-As diode laser device was used as a source of low-power laser. Patients were performed laser therapy with a probe of LO7 with a wavelength of 810 nm and 50 mW output power in pulse radiation mode (F = 3,000, peak power = 80 W, Δt = 200 ns, density = 0.05 W/cm2, dose = 6 J/cm2, area = 1 cm2) and also a probe of MLO1K with a power output of 30 mW and a wavelength of 890 nm in pulse radiation mode (F = 3,000 Hz, peak power = 50 W, Δt = 200 ns, density = 0.017 W/cm2, total dose = 10 J/cm2), and were given low-level laser therapy (LLLT) three times a week with a total number of 12 sessions. Data were analyzed using SPSS ver. 15, and the obtained data were reported as mean ± SD and frequency (%). To analyze the data, repeated measurement and marginal homogeneity approaches were used.


In the current study, a significant reduction was observed regarding the nocturnal pain, pain on walking and ascending the steps, knee circumference, distance between the hip and heel, and knee to horizontal hip to heel distance at the end of the treatment course.


In brief, the current study focuses on the fact that LLLT is effective in reducing pain in knee osteoarthritis.

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Fig. 1



Low-level laser therapy


Transcutaneous electrical nerve stimulation




Western Ontario and McMaster Universities


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We would like to offer our special thanks to the Iranian Laser Association for assisting us throughout the current study.

Financial disclosure

The authors declare they have no financial disclosure.


This article is not supported by any funding organization. There is no sponsor for this work.

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Correspondence to Hassan Soleimanpour.

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Authors’ information

HS is Associate professor of Anesthesiology and Critical Care, Fellowship in Trauma Critical Care and CPR at the Department of Emergency Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. He is also editorial board member of  Emergency medicine journal (EGM) and Pakistan Journal of Biological Sciences (PJBS) and member of World Stroke Organization (WSO), too. KG and RT are anesthesiologists and members of  Iranian Medical Laser Association, Tehran, Iran. SEJG is an anesthesiologist at the Department of Anesthesiology, Tabriz University of Medical Sciences, Tabriz, Iran. SS is resident of Anesthesiology and Critical Care Department, Iran University of Medical Sciences, Tehran, Iran and Managing  Editor at Anesthesiology and Pain Medicine Journal. RME is member of Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. AI is anesthesiologist at Saudi German Hospital, Dubai, United Arab Emirates.

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Soleimanpour, H., Gahramani, K., Taheri, R. et al. The effect of low-level laser therapy on knee osteoarthritis: prospective, descriptive study. Lasers Med Sci 29, 1695–1700 (2014).

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  • Knee osteoarthritis
  • Low-level laser therapy
  • Pain