Lasers in Medical Science

, Volume 29, Issue 5, pp 1593–1598 | Cite as

Effects of 660- and 980-nm low-level laser therapy on neuropathic pain relief following chronic constriction injury in rat sciatic nerve

  • M. Masoumipoor
  • S. B. JameieEmail author
  • A. Janzadeh
  • F. Nasirinezhad
  • M. Soleimani
  • M. Kerdary
Original Article


Neuropathic pain (NP) is one of the most suffered conditions in medical disciplines. The role of reactive oxygen species (ROS) and oxidative stress in the induction of NP was studied by many researchers. Neuropathies lead to medical, social, and economic isolation of the patient, so various therapies were used to treat or reduce it. During the recent years, low-level laser therapy (LLLT) has been used in certain areas of medicine and rehabilitation. Chronic constriction injury (CCI) is a well-known model for neuropathic pain studies. In order to find the effects of different wavelengths of LLLT on the injured sciatic nerve, the present research was done. Thirty Wistar adult male rats (230–320 g) were used in this study. The animals were randomly divided into three groups (n = 10). To induce neuropathic pain for the sciatic nerve, the CCI technique was used. Low-level laser of 660 and 980 nm was used for two consecutive weeks. Thermal and mechanical hyperalgesia was done before and after surgery on days 7 and 14, respectively. Paw withdrawal thresholds were also evaluated. CCI decreased the pain threshold, whereas both wavelengths of LLLT for 2 weeks increased mechanical and thermal threshold significantly. A comparison of the mechanical and thermal threshold showed a significant difference between the therapeutic effects of the two groups that received LLLT. Based on our findings, the laser with a 660-nm wavelength had better therapeutic effects than the laser with a 980-nm wavelength, so the former one may be used for clinical application in neuropathic cases; however, it needs more future studies.


Low-level laser therapy CCI Neuropathic pain 



The authors would like to thank the Medical Basic Sciences Laboratory (Faculty of Allied Medicine, TUMS) and Pain Laboratory (Faculty of Medicine, TUMS).


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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  • M. Masoumipoor
    • 1
  • S. B. Jameie
    • 1
    • 2
    • 3
    Email author
  • A. Janzadeh
    • 2
    • 4
  • F. Nasirinezhad
    • 4
  • M. Soleimani
    • 3
  • M. Kerdary
    • 2
  1. 1.Department of Nuclear Engineering, Sciences and Researches BranchIslamic Azad UniversityTehranIran
  2. 2.Department of Medical Basic Sciences, Faculty of Allied MedicineIUMSTehranIslamic Republic of Iran
  3. 3.Department of Anatomy, Faculty of MedicineIUMSTehranIran
  4. 4.Research Center of Physiology, Faculty of MedicineIUMSTehranIran

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