Lasers in Medical Science

, Volume 30, Issue 5, pp 1609–1618 | Cite as

Efficacy of low-level laser therapy for accelerating tooth movement during orthodontic treatment: a systematic review and meta-analysis

  • M. K. Ge
  • W. L. He
  • J. Chen
  • C. Wen
  • X. Yin
  • Z. A. Hu
  • Z. P. Liu
  • S. J. ZouEmail author
Review Article


This review aimed to evaluate the efficacy of low-level laser therapy (LLLT) for accelerating tooth movement during orthodontic treatment. An extensive electronic search was conducted by two reviewers. Randomized controlled trials (RCTs) and quasi-RCTs concerning the efficacy of LLLT for accelerating tooth movement during orthodontic treatment were searched in CENTRAL, Medline, PubMed, Embase, China Biology Medicine Disc (CBM), China National Knowledge Infrastructure (CNKI), and Google Scholar. Six RCTs and three quasi-RCTs, involving 211 patients from six countries, were selected from 173 relevant studies. All nine articles were feasible for the systematic review and meta-analysis, five of which were assessed as moderate risk of bias, while the rest were assessed as high risk of bias. The mean difference and the 95 % confidence interval (95 % CI) of accumulative moved distance of teeth were observed among all the researches. The results showed that the LLLT could accelerate orthodontic tooth movement (OTM) in 7 days (mean difference 0.19, 95 % CI [0.02, 0.37], p = 0.03) and 2 months (mean difference 1.08, 95 % CI [0.16, 2.01], p = 0.02). Moreover, a relatively lower energy density (5 and 8 J/cm2) was seemingly more effective than 20 and 25 J/cm2 and even higher ones.


Low-level laser therapy Tooth movement Orthodontic Systematic review Meta-analysis 



This work was supported by the National Nature Science Foundation of China (grant number 81271178).


  1. 1.
    Matsumoto T, Iimura T, Ogura K, Moriyama K, Yamaguchi A (2013) The role of osteocytes in bone resorption during orthodontic tooth movement. J Dent Res 92(4):340–345PubMedCrossRefGoogle Scholar
  2. 2.
    Jatania A, Shivalinga BM, Kiran J (2012) Root resorption after orthodontic treatment: a review. Int J Orthod Milwaukee 23(2):45–49PubMedGoogle Scholar
  3. 3.
    Geiger AM, Gorelick L, Gwinnett AJ, Benson BJ (1992) Reducing white spot lesions in orthodontic populations with fluoride rinsing. Am J Orthod Dentofacial Orthop 101(5):403–407PubMedCrossRefGoogle Scholar
  4. 4.
    Collins MK, Sinclair PM (1988) The local use of vitamin D to increase the rate of orthodontic tooth movement. Am J Orthod Dentofacial Orthop 94(4):278–284PubMedCrossRefGoogle Scholar
  5. 5.
    Kobayashi Y, Takagi H, Sakai H, Hashimoto F, Mataki S, Kobayashi K, Kato Y (1998) Effects of local administration of osteocalcin on experimental tooth movement. Angle Orthod 68(3):259–266PubMedGoogle Scholar
  6. 6.
    Yamasaki K, Shibata Y, Imai S, Tani Y, Shibasaki Y, Fukuhara T (1984) Clinical application of prostaglandin E1 (PGE1) upon orthodontic tooth movement. Am J Orthod 85(6):508–518PubMedCrossRefGoogle Scholar
  7. 7.
    Davidovitch Z, Finkelson MD, Steigman S, Shanfeld JL, Montgomery PC, Korostoff E (1980) Electric currents, bone remodeling, and orthodontic tooth movement. I. The effect of electric currents on periodontal cyclic nucleotides. Am J Orthod 77(1):14–32PubMedCrossRefGoogle Scholar
  8. 8.
    Davidovitch Z, Finkelson MD, Steigman S, Shanfeld JL, Montgomery PC, Korostoff E (1980) Electric currents, bone remodeling, and orthodontic tooth movement. II. Increase in rate of tooth movement and periodontal cyclic nucleotide levels by combined force and electric current. Am J Orthod 77(1):33–47PubMedCrossRefGoogle Scholar
  9. 9.
    Showkatbakhsh R, Jamilian A, Showkatbakhsh M (2010) The effect of pulsed electromagnetic fields on the acceleration of tooth movement. World J Orthod 11(4):e52–e56PubMedGoogle Scholar
  10. 10.
    Aboul-Ela SM, El-Beialy AR, El-Sayed KM, Selim EM, El-Mangoury NH, Mostafa YA (2011) Miniscrew implant-supported maxillary canine retraction with and without corticotomy-facilitated orthodontics. Am J Orthod Dentofacial Orthop 139(2):252–259PubMedCrossRefGoogle Scholar
  11. 11.
    Hassan AH, Al-Fraidi AA, Al-Saeed SH (2010) Corticotomy-assisted orthodontic treatment: review. Open Dent J 4:159–164PubMedCentralPubMedCrossRefGoogle Scholar
  12. 12.
    Seifi M, Eslami B, Saffar AS (2003) The effect of prostaglandin E2 and calcium gluconate on orthodontic tooth movement and root resorption in rats. Eur J Orthod 25(2):199–204PubMedCrossRefGoogle Scholar
  13. 13.
    Gontijo IT, Navarro RS, Ciamponi AL, Zezell DM (2008) Whitening techniques using the diode laser and halogen lamp in human devitalized primary teeth. J Dent Child (Chic) 75(2):164–167Google Scholar
  14. 14.
    Huth KC, Neuhaus KW, Gygax M, Bücher K, Crispin A, Paschos E, Hickel R, Lussi A (2008) Clinical performance of a new laser fluorescence device for detection of occlusal caries lesions in permanent molars. J Dent 36(12):1033–1040PubMedCrossRefGoogle Scholar
  15. 15.
    Zand N, Ataie-Fashtami L, Djavid GE, Fateh M, Alinaghizadeh MR, Fatemi SM, Arbabi-Kalati F (2009) Relieving pain in minor aphthous stomatitis by a single session of non-thermal carbon dioxide laser irradiation. Lasers Med Sci 24(4):515–520PubMedCrossRefGoogle Scholar
  16. 16.
    Kim YD, Kim SS, Hwang DS, Kim SG, Kwon YH, Shin SH, Kim UK, Kim JR, Chung IK (2007) Effect of low-level laser treatment after installation of dental titanium implant-immunohistochemical study of RANKL, RANK, OPG: an experimental study in rats. Lasers Surg Med 39(5):441–450PubMedCrossRefGoogle Scholar
  17. 17.
    Khadra M (2005) The effect of low level laser irradiation on implant-tissue interaction. In vivo and in vitro studies. Swed Dent J Suppl 172:1–63PubMedGoogle Scholar
  18. 18.
    Altan BA, Sokucu O, Ozkut MM, Inan S (2012) Metrical and histological investigation of the effects of low-level laser therapy on orthodontic tooth movement. Lasers Med Sci 27(1):131–140PubMedCrossRefGoogle Scholar
  19. 19.
    Kawasaki K, Shimizu N (2000) Effects of low-energy laser irradiation on bone remodeling during experimental tooth movement in rats. Lasers Surg Med 26(3):282–291PubMedCrossRefGoogle Scholar
  20. 20.
    Sun X, Zhu X, Xu C, Ye N, Zhu H (2001) Effects of low energy laser on tooth movement and remodeling of alveolar bone in rabbits. Hua Xi Kou Qiang Yi Xue Za Zhi 19(5):290–293PubMedGoogle Scholar
  21. 21.
    Yamaguchi M, Hayashi M, Fujita S, Yoshida T, Utsunomiya T, Yamamoto H, Kasai K (2010) Low-energy laser irradiation facilitates the velocity of tooth movement and the expressions of matrix metalloproteinase-9, cathepsin K, and alpha(v) beta(3) integrin in rats. Eur J Orthod 32(2):131–139PubMedCrossRefGoogle Scholar
  22. 22.
    Cruz DR, Kohara EK, Ribeiro MS, Wetter NU (2004) Effects of low-intensity laser therapy on the orthodontic movement velocity of human teeth: a preliminary study. Lasers Surg Med 35(2):117–120PubMedCrossRefGoogle Scholar
  23. 23.
    Doshi-Mehta G, Bhad-Patil WA (2012) Efficacy of low-intensity laser therapy in reducing treatment time and orthodontic pain: a clinical investigation. Am J Orthod Dentofacial Orthop 141(3):289–297PubMedCrossRefGoogle Scholar
  24. 24.
    Fujiyama K, Deguchi T, Murakami T, Fujii A, Kushima K, Takano-Yamamoto T (2008) Clinical effect of CO(2) laser in reducing pain in orthodontics. Angle Orthod 78(2):299–303PubMedCrossRefGoogle Scholar
  25. 25.
    Gui L, Qu H (2008) Clinical application of low energy laser in acceleration of orthodontic tooth movement. Journal of Dalian Medical University 30:155–156Google Scholar
  26. 26.
    Limpanichkul W, Godfrey K, Srisuk N, Rattanayatikul C (2006) Effects of low-level laser therapy on the rate of orthodontic tooth movement. Orthod Craniofac Res 9(1):38–43PubMedCrossRefGoogle Scholar
  27. 27.
    Sousa MV, Scanavini MA, Sannomiya EK, Velasco LG, Angelieri F (2011) Influence of low-level laser on the speed of orthodontic movement. Photomed Laser Surg 29(3):191–196PubMedCrossRefGoogle Scholar
  28. 28.
    Wang TJ, Liu DX, Dong ZY (2007) Efficacy of low-level laser therapy for accelerating tooth movement in orthodontic treatment. China Medical Herald 4(12):147–149Google Scholar
  29. 29.
    Xu CW, Zhang ZJ, Zhao J, Cao GD (2006) The effect of low energy laser on accelerating orthodontic tooth movement. Med J Qilu 21(1):45–47Google Scholar
  30. 30.
    Youssef M, Ashkar S, Hamade E, Gutknecht N, Lampert F, Mir M (2008) The effect of low-level laser therapy during orthodontic movement: a preliminary study. Lasers Med Sci 23(1):27–33PubMedCrossRefGoogle Scholar
  31. 31.
    Arany PR, Nayak RS, Hallikerimath S, Limaye AM, Kale AD, Kondaiah P (2007) Activation of latent TGF-beta1 by low-power laser in vitro correlates with increased TGF-beta1 levels in laser-enhanced oral wound healing. Wound Repair Regen 15(6):866–874PubMedCrossRefGoogle Scholar
  32. 32.
    Hawkins D, Houreld N, Abrahamse H (2005) Low level laser therapy (LLLT) as an effective therapeutic modality for delayed wound healing. Ann N Y Acad Sci 1056:486–493PubMedCrossRefGoogle Scholar
  33. 33.
    Aimbire F, Bjordal JM, Iversen VV, Albertini R, Frigo L, Pacheco MT, Castro-Faria-Neto HC, Chavantes MC, Labat RM, Lopes-Martins RA (2006) Low level laser therapy partially restores trachea muscle relaxation response in rats with tumor necrosis factor alpha-mediated smooth airway muscle dysfunction. Lasers Surg Med 38(8):773–778PubMedCrossRefGoogle Scholar
  34. 34.
    Hawkins D, Abrahamse H (2006) Effect of multiple exposures of low-level laser therapy on the cellular responses of wounded human skin fibroblasts. Photomed Laser Surg 24(6):705–714PubMedCrossRefGoogle Scholar
  35. 35.
    Huang TH, Liu SL, Chen CL, Shie MY, Kao CT (2013) Low-level laser effects on simulated orthodontic tension side periodontal ligament cells. Photomed Laser Surg 31(2):72–77PubMedCentralPubMedCrossRefGoogle Scholar
  36. 36.
    Gigo-Benato D, Russo TL, Tanaka EH, Assis L, Salvini TF, Parizotto NA (2010) Effects of 660 and 780 nm low-level laser therapy on neuromuscular recovery after crush injury in rat sciatic nerve. Lasers Surg Med 42(9):673–682PubMedCrossRefGoogle Scholar
  37. 37.
    He WL, Li CJ, Liu ZP, Sun JF, Hu ZA, Yin X, Zou SJ (2012) Efficacy of low-level laser therapy in the management of orthodontic pain: a systematic review and meta-analysis. Lasers Med Sci doi. doi: 10.1007/s10103-012-1196-y Google Scholar
  38. 38.
    Saito S, Shimizu N (1997) Stimulatory effects of low-power laser irradiation on bone regeneration in midpalatal suture during expansion in the rat. Am J Orthod Dentofacial Orthop 111(5):525–532PubMedCrossRefGoogle Scholar
  39. 39.
    Genc G, Kocadereli I, Tasar F, Kilinc K, El S, Sarkarati B (2013) Effect of low-level laser therapy (LLLT) on orthodontic tooth movement. Lasers Med Sci 28(1):41–47PubMedCrossRefGoogle Scholar
  40. 40.
    Karu TI, Pyatibrat LV, Afanasyeva NI (2004) A novel mitochondrial signaling pathway activated by visible-to-near infrared radiation. Photochem Photobiol 80(2):366–372PubMedCrossRefGoogle Scholar
  41. 41.
    Proff P, Römer P (2009) The molecular mechanism behind bone remodelling: a review. Clin Oral Investig 13(4):355–362PubMedCrossRefGoogle Scholar
  42. 42.
    Yamaguchi M (2009) RANK/RANKL/OPG during orthodontic tooth movement. Orthod Craniofac Res 12(2):113–119PubMedCrossRefGoogle Scholar
  43. 43.
    Fujita S, Yamaguchi M, Utsunomiya T, Yamamoto H, Kasai K (2008) Low-energy laser stimulates tooth movement velocity via expression of RANK and RANKL. Orthod Craniofac Res 11(3):143–155PubMedCrossRefGoogle Scholar
  44. 44.
    Do Nascimento RX, Callera F (2006) Low-level laser therapy at different energy densities (0.1–2.0 J/cm2) and its effects on the capacity of human long-term cryopreserved peripheral blood progenitor cells for the growth of colony-forming units. Photomed Laser Surg 24(5):601–604PubMedCrossRefGoogle Scholar
  45. 45.
    Goulart CS, Nouer PR, Mouramartins L, Garbin IU, de Fátima Zanirato Lizarelli R (2006) Photoradiation and orthodontic movement: experimental study with canines. Photomed Laser Surg 24(2):192–196PubMedCrossRefGoogle Scholar
  46. 46.
    Schindl A, Merwald H, Schindl L, Kaun C, Wojta J (2003) Direct stimulatory effect of low-intensity 670 nm laser irradiation on human endothelial cell proliferation. Br J Dermatol 148(2):334–336PubMedCrossRefGoogle Scholar
  47. 47.
    Seifi M, Shafeei HA, Daneshdoost S, Mir M (2007) Effects of two types of low-level laser wave lengths (850 and 630 nm) on the orthodontic tooth movements in rabbits. Lasers Med Sci 22(4):261–264PubMedCrossRefGoogle Scholar
  48. 48.
    Amaral AC, Parizotto NA, Salvini TF (2001) Dose-dependency of low-energy HeNe laser effect in regeneration of skeletal muscle in mice. Lasers Med Sci 16(1):44–51PubMedCrossRefGoogle Scholar
  49. 49.
    Parker S (2007) Laser regulation and safety in general dental practice. Br Dent J 202(9):523–532PubMedCrossRefGoogle Scholar
  50. 50.
    Long H, Pyakurel U, Wang Y, Liao L, Zhou Y, Lai W (2013) Interventions for accelerating orthodontic tooth movement: a systematic review. Angle Orthod 83(1):164–171PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  • M. K. Ge
    • 1
  • W. L. He
    • 2
  • J. Chen
    • 1
  • C. Wen
    • 3
  • X. Yin
    • 1
  • Z. A. Hu
    • 1
  • Z. P. Liu
    • 1
  • S. J. Zou
    • 1
    Email author
  1. 1.State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of StomatologySichuan UniversityChengduChina
  2. 2.Department of OrthodonticsGuangdong Provincial Stomatological Hospital, the Affiliated Stomatological Hospital of Southern Medical UniversityGuangzhouChina
  3. 3.State Key Laboratory of Oral Diseases, Department of Prosthodontics, West China Hospital of StomatologySichuan UniversityChengduChina

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