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Lasers in Medical Science

, Volume 29, Issue 1, pp 221–223 | Cite as

In vitro cell tests of pancreatic malignant tumor cells by photothermotherapy based on DMSO porous silicon colloids

  • Chanseok Hong
  • Chongmu LeeEmail author
Original Article

Abstract

Dimethyl sulfoxide porous silicon (DMSO-PSi) colloid in which DMSO was used as a surfactant suitable for inhibiting the agglomeration of PSi nanoparticles was prepared for use in cancer photothermotherapy. The photothermal effect of the DMSO-PSi colloid was found to be high enough to destroy cancer cells (T = ∼52 °C). The mean particle size of the PSi nanoparticles in the DMSO-PSi colloid was 67 nm, which is low enough to flow through blood vessels without causing a blockage. The DMSO-PSi colloid in combination with an NIR laser resulted in a cell viability of 5.70 %, which is a sufficiently high cytotoxic effect.

Keywords

Porous silicon nanoparticles Photothermotherapy Near-infrared light Surfactant 

Notes

Acknowledgments

This study was supported by the Korea Science and Engineering Foundation through “the 2010 Core Research Program.”

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Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  1. 1.Department of Materials Science and EngineeringInha UniversityIncheonRepublic of Korea

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