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The effects of minimally invasive laser needle system on suppression of trabecular bone loss induced by skeletal unloading

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An Erratum to this article was published on 25 June 2013

Abstract

This study was aimed to evaluate the effects of low-level laser therapy (LLLT) in the treatment of trabecular bone loss induced by skeletal unloading. Twelve mice have taken denervation operation. At 2 weeks after denervation, LLLT (wavelength, 660 nm; energy density, 3 J/cm2) was applied to the right tibiae of six mice (LASER) for 5 days/week over 2 weeks by using a minimally invasive laser needle system (MILNS) which consists of a 100 μm optical fiber in a fine needle (diameter, 130 μm). Structural parameters and histograms of bone mineralization density distribution (BMDD) were obtained before LLLT and at 2 weeks after LLLT. In addition, osteocyte, osteoblast, and osteoclast populations were counted. Two weeks after LLLT, bone volume fraction, trabeculae number, and trabeculae thickness were significantly increased and trabecular separations, trabecular bone pattern factor, and structure model index were significantly decreased in LASER than SHAM (p < 0.05). BMDD in LASER was maintained while that in SHAM was shifted to lower mineralization. Osteocyte and osteoblast populations were significantly increased but osteoclast population was significantly decreased in LASER when compared with those in SHAM (p < 0.05). The results indicate that LLLT with the MILNS may enhance bone quality and bone homeostasis associated with enhancement of bone formation and suppression of bone resorption.

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Acknowledgments

This research was supported by the Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST; 2010-00757).

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Author notes

  1. Hyunsoo Kim

    Present address: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

  2. Yeonhang Ryu

    Present address: Korean National Evidence-based Healthcare Collaborating Agency, Seoul, 110-450, Korea

Authors and Affiliations

  1. Research Team, Korea Orthopedics and Rehabilitation Engineering Center, Incheon, 403-712, Republic of Korea

    Chang-Yong Ko

  2. Department of Biomedical Engineering and Yonsei-Fraunhofer medical device lab, Yonsei University, Yonseidae-gil 1, Maeji, Heungup, Wonju, Gangwon-Do, 220-710, Republic of Korea

    Heesung Kang, Yeonhang Ryu, Byungjo Jung & Han Sung Kim

  3. Department of Microbiology and the Aging-associated Vascular Disease Research Center, College of Medicine, Yeungnam University, Daegu, 705-717, Republic of Korea

    Hyunsoo Kim & Daewon Jeong

  4. IHBR, Department of Oral Pathology, School of Dentistry, Kyungpook National University, Daegu, 700-412, Republic of Korea

    Hong-In Shin

  5. Department of Mechanical Engineering, College of Engineering, Sejong University, Seoul, 143-747, Republic of Korea

    Dohyung Lim

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  1. Chang-Yong Ko
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Correspondence to Han Sung Kim.

Additional information

Chang-Yong Ko and Heesung Kang contributed equally to this work.

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Ko, CY., Kang, H., Ryu, Y. et al. The effects of minimally invasive laser needle system on suppression of trabecular bone loss induced by skeletal unloading. Lasers Med Sci 28, 1495–1502 (2013). https://doi.org/10.1007/s10103-013-1265-x

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  • DOI: https://doi.org/10.1007/s10103-013-1265-x

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