Lasers in Medical Science

, Volume 27, Issue 2, pp 431–436 | Cite as

Effects of the Lexington LaserComb on hair regrowth in the C3H/HeJ mouse model of alopecia areata

  • Tongyu Cao Wikramanayake
  • Rosa Rodriguez
  • Sonal Choudhary
  • Lucia M. Mauro
  • Keyvan Nouri
  • Lawrence A. Schachner
  • Joaquin J. JimenezEmail author
Original Article


Alopecia areata (AA) is a common autoimmune disease that presents with non-scarring alopecia. It is characterized by intra- or peri-follicular lymphocytic infiltrates composed of CD4+ and CD8+ T-cells on histology. To this day, few treatments are effective for AA. Here we present findings of using a low-level laser comb to alleviate the symptoms of AA in a C3H/HeJ mouse model for AA. Fourteen C3H/HeJ mice with induced AA were used in this study. Two were killed to confirm AA through histology. The remaining 12 mice were randomized into two groups; group I received HairMax LaserComb (wavelength: 655 nm, beam diameter <5 mm; divergence 57 mrad; nine lasers) for 20 s daily, three times per week for a total of 6 weeks; group II was treated similarly, except that the laser was turned off (sham-treated). After 6 weeks of LaserComb treatment, hair regrowth was observed in all the mice in group I (laser-treated) but none in group II (sham-treated). On histology, increased number of anagen hair follicles was observed in laser-treated mice. On the other hand, sham-treated mice demonstrated hair follicles in the telogen phase with no hair shaft. LaserComb seems to be an effective and convenient device for the treatment of AA in the C3H/HeJ mouse model. Human studies are required to determine the efficacy and safety of this device for AA therapy.


LaserComb 655-nm laser Alopecia areata C3H/HeJ mice 



We are grateful for the generous support from Locks of Love to Dr. J.J.Jimenez. The HairMax LaserCombs were provided by Lexington International, LLC (Boca Raton, FL). Dr. T.C. Wikramanayake is supported by a Career Development Award (AR050487) from NIH/NIAMS.


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Copyright information

© Springer-Verlag London Ltd 2011

Authors and Affiliations

  • Tongyu Cao Wikramanayake
    • 1
  • Rosa Rodriguez
    • 1
    • 2
  • Sonal Choudhary
    • 3
  • Lucia M. Mauro
    • 4
  • Keyvan Nouri
    • 3
  • Lawrence A. Schachner
    • 1
  • Joaquin J. Jimenez
    • 1
    Email author
  1. 1.Department of Dermatology and Cutaneous SurgeryUniversity of Miami, Miller School of MedicineMiamiUSA
  2. 2.Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood InstituteNational Institutes of HealthBethesdaUSA
  3. 3.Department of Dermatology and Cutaneous SurgeryUniversity of Miami, Miller School of MedicineMiamiUSA
  4. 4.Department of Biochemistry and Molecular BiologyUniversity of Miami, Miller School of MedicineMiamiUSA

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