Abstract
The study defined the scientific evaluation of glycemic elements of extracts of Cynodon dactylon and Musa paradisiaca. A dose of 500 mg/kg body weight (bw) of C. dactylon produced maximum falls of 23.2% and 22.8% in blood glucose levels of normoglycemic rats during studies of fasting blood glucose and glucose tolerance, respectively, whereas the same dose of M. paradisiaca produced a rise of 34.9% and 18.4%. In diabetic rats during glucose tolerance tests, a fall of 27.8% and a rise of 17.5% were observed with the same dose of C. dactylon and M. paradisiaca, respectively. Laser-induced breakdown spectroscopy used for detection of glycemic elements present in both the extracts indicated that C. dactylon was rich in magnesium (Mg), whereas M. paradisiaca was rich in potassium (K) and sodium (Na), comparatively, suggesting thereby the defined roles of these elements in diabetes management.
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Abbreviations
- BGL:
-
Blood glucose level
- bw:
-
Body weight
- FBG:
-
Fasting blood glucose
- GTT:
-
Glucose tolerance test
- LIBS:
-
Laser-induced breakdown spectroscopy
- PPG:
-
Post-prandial glucose
- SD:
-
Standard deviation
- STZ:
-
Streptozotocin
References
Ivorra MD, Paya M, Villar A (1989) A review of natural products and plants as potential antidiabetic drugs. J Ethnopharmacol 27:243–275. doi:10.1016/0378-8741(89)90001-9
Bailey LJ, Day C (1989) Traditional plant medicine as treatment for diabetes. Diabetes Care 12:553–564. doi:10.2337/diacare.12.8.553
Rai PK, Jaiswal DJ, Diwakar S, Watal G (2008) Antihyperglycemic profile of Trichosanthes dioica seeds in experimental models. Pharm Biol 46:360–365. doi:10.1080/13880200801888011
Punitha ISR, Rajendran K, Shirwaikar A, Shirwaikar A (2005) Alcoholic stem extract of Coscinium fenestratum regulates carbohydrate metabolism and improves antioxidant status in streptozotocin–nicotinamide induced diabetic rats. Evid Based Complement Altern Med 2:375–381. doi:10.1093/ecam/neh099
Li WL, Zheng HC, Bukuru J, de Kimpe N (2004) Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol 92:1–21. doi:10.1016/j.jep.2003.12.031
Wright CI, Van-Buren L, Kroner CI, Koning MMG (2007) Herbal medicines as diuretics: a review of the scientific evidence. J Ethnopharmacol 114:1–31. doi:10.1016/j.jep.2007.07.023
El-Hilaly J, Tahraoui A, Israili JH, Lyoussi B (2006) Hypolipidemic effect of acute and sub-chronic administration of an aqueous extract of Ajuga Inva L. whole plant in normal and diabetic rats. J Ethnopharmacol 105:441–448. doi:10.1016/j.jep.2005.11.023
El-Hilaly J, Hmammuchi M, Lyoussi B (2003) Ethnobotanical studies and economic evaluation of medicinal plants in Taounate providence (Northern Morocco). J Ethnopharmacol 86:251–255. doi:10.1016/S0378-8741(03)00012-6
Kar A, Choudhary BK, Bandyopadhyay NG (2003) Comparative evaluation of hypoglycemic activity of some Indian medicinal plant in alloxan diabetic rats. J Ethnopharmacol 84:105–108. doi:10.1016/S0378-8741(02)00144-7
Mukherjee PK, Kumar V, N Kumar S, Heinrich M (2008) The Ayurvedic medicine Clitoria ternatea—from traditional use to scientific assessment. J Ethnopharmacol 120:291–301. doi:10.1016/j.jep.2008.09.009
Rai AK, Rai VN, Yueh FU, Singh JP (2003) Laser-induced breakdown spectroscopy: a versatile technique for elemental analysis. Trends Appl Spectrosc 4:165–169
Rai AK, Rai VN, Rai DK, Thakur SN, Yueh FU, Singh JP (2007) Laser induced breakdown spectroscopy of solid and molten materials. Elsevier Science, The Netherlands
Rai AK, Zhang H, Yueh FU, Singh JP, Weisburg A (2001) Parametric study of a fiber optic laser induced breakdown spectroscopy of probe for analysis of aluminum alloy. Spectrochim Acta B At Spectrosc 56:2371–2383
Piepmeier EH (1986) Laser ablation for atomic spectroscopy. In: Piepmeier EH (ed) Analytical application of lasers, Wiley, New York
Singh SK, Kesari AN, Gupta RK, Jaiswal DJ, Watal G (2007) Assessment of antidiabetic potential of Cynodon dactylon extract in streptozotocin diabetic rats. J Ethnopharmacol 114:174–179. doi:10.1016/j.jep.2007.07.039
Singh SK, Kesari AN, Rai PK, Watal G (2007) Assessment of glycemic potential of Musa paradisiaca stem juice. Indian J Clin Biochem 22:48–52. doi:10.1007/BF02913313
Dhar ML, Dhawan M, Melhrotra (1968) Screening of Indian plants for biological activity: part I. Indian J Exp Biol 6:232–247
Ahmed S, Reza MS, Jabbar A (1994) Antimicrobial activity of Cynodon dactylon. Fitoterapia 65:463–464
Singh SK, Rai PK, Jaiswal D, Watal G (2007) Evidence based critical evaluation of glycemic potential of Cynodon dactylon. Evid Based Complement Altern Med 5:415–420. doi:10.1093ecamnem044
Chopra RN, Handa KL (1982) Indigenous drugs of India, 2nd edn. Academic, India
Kirtikar KR, Basu BD (1935) Indian medicinal plants, vol 2, 2nd edn. Lalit Mohan
Patil MB, Patil SS, Prakash NS, Jalandpure SS, Kokate C (2005) Antiulcer properties of alcoholic extract of C. dactylon in rats. J Pharmacol 680:115–118
Prasad KV, Bharthri K, Srinivasan K (1993) Evaluation of Musa (paradisiaca Linn. cultivator)—“Puttubale” stem juice for antilithiatic activity in albino rats. Indian J Physiol Pharmacol 37:337–341
Pari L, Maheshwari UJ (1999) Hypoglycemic effect of Musa sapientum L. in alloxan-induced diabetic rats. J Ethnopharmacol 68:321–325. doi:10.1016/S0378-8741(99)00088-4
Pari L, Maheshwari UJ (2000) Antihyperglycemic activity of Musa sapientum flowers: effect on lipid peroxidation in alloxan diabetic rats. Phytother Res 14:136–138. doi:10.1002/(SICI)1099-1573(200003)14:2<136::AID-PTR607>3.0.CO;2-K
Ghosal S (1985) Steryl glycosides and acyl steryl glycosides from Musa paradisiaca. Phytochem 24:1807–1810. doi:10.1016/S0031-9422(00)82556-X
Mondal SK, Ray B, Thakur S, Ghosal PK (2001) Isolation purification and some structural features of mucilaginous exudates from Musa paradisiaca. Fitoterapia 72:263–271. doi:10.1016/S0367-326X(00)00295-1
Brahm D, Trinder P (1972) Estimation of glucose by glucose oxidase method. Analyst (Lond) 97:142–145. doi:10.1039/an9729700142
Smith LH, Their SO (1999) Fisiopatologia. Principios biologicos dela enfermedad. Editorial Medica Panamericana, Buenos Aires, pp 1549–1600
Kumar GS, Nayak H, Dharmesh SM, Salimath PV (2006) Free and bound phenolic antioxidants in amla (Emblica officinalis) and turmeric (Curcuma longa). J Food Compost Anal 19:446–452. doi:10.1016/j.jfca.2005.12.015
Mertz W (1981) The essential trace elements. Science 213):1332–1338. doi:10.1126/science.7022654
Underwood EJ, Mertz W (1986) Trace elements in human and animal nutrition. Vol. I. Academic Press, New York
Kar A, Choudhary BK, Bandyopadhyaya NG (1999) Preliminary studies on the inorganic constituents of some indigenous hypoglycemic herbs on oral glucose tolerance test. J Ethnopharmacol 64:179–184. doi:10.1016/S0378-8741(98)00118-4
Khan A, Safdar M (2003) Role of diet, nutrients, spices and natural products in diabetes mellitus. Pak J Nutr. 2:1–12
Rai PK, Rai NK, Rai AK, Watal G (2007) Role of LIBS in elemental analysis of Psidium guajava responsible for glycemic potential. Instrum Sci Technol 35:507–522. doi:10.1080/10739140701540230
Rai PK, Rai NK, Pandhija S, Rai AK, Watal G (2006) Screening of glycemic elements in ethnobotanical plant by laser Induced breakdown spectroscopy. National Conference on LIBS, IIT Chennai, 21–22 December, p 44
Elson M, Haas MD (2007) Role of potassium in maintaining health. http://www.hkpp.org/general/potassium_health.html.
Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS (2003) Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care 26:1277–1294. doi:10.2337/diacare.26.4.1277
Ridaura RL, Willett WC, Rimm EB, Liu S, Stampeer MJ, Manson JE, Hu FB (2004) Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care 27:134–140. doi:10.2337/diacare.27.1.134
Acknowledgment
The authors are thankful to the National Medicinal Plants Board (NMPB), the Ministry of Health and Family Welfare of the Government of India, and DRDO New Delhi, India, for providing financial assistance.
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Rai, P.K., Jaiswal, D., Rai, N.K. et al. Role of glycemic elements of Cynodon dactylon and Musa paradisiaca in diabetes management. Lasers Med Sci 24, 761–768 (2009). https://doi.org/10.1007/s10103-008-0637-0
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DOI: https://doi.org/10.1007/s10103-008-0637-0
Keywords
- Cynodon dactylon
- Diabetes
- Laser-induced breakdown spectroscopy (LIBS)
- Musa paradisiaca
- Natural product