Lasers in Medical Science

, Volume 24, Issue 2, pp 284–289 | Cite as

Hematoporphyrin-mediated fluorescence reflectance imaging: application to early tumor detection in vivo in small animals

  • Maddalena Autiero
  • Rosanna Cozzolino
  • Paolo Laccetti
  • Marcello Marotta
  • Maria Quarto
  • Patrizia Riccio
  • Giuseppe Roberti
Brief Report


The in vivo early detection of subcutaneous human tumors implanted in small animals was studied by laser-induced fluorescence reflectance imaging (FRI), with a hematoporphyrin (HP) compound as an exogenous optical contrast agent. Tumor detection was shown to be possible just 3 days after the inoculation of tumor cells, when tumors were neither visible nor palpable. However, this detection capability is limited to a temporal window of approximately 100 h from HP administration and to a low optical contrast of the tumor (<2).


Hematoporphyrins Tumor Fluorescence Lasers Early diagnosis 


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Copyright information

© Springer-Verlag London Limited 2007

Authors and Affiliations

  • Maddalena Autiero
    • 1
  • Rosanna Cozzolino
    • 2
  • Paolo Laccetti
    • 2
  • Marcello Marotta
    • 3
  • Maria Quarto
    • 1
  • Patrizia Riccio
    • 4
    • 5
  • Giuseppe Roberti
    • 1
    • 5
  1. 1.Dipartimento di Scienze FisicheUniversità di Napoli Federico IINaplesItaly
  2. 2.Dipartimento di Biologia Strutturale e FunzionaleUniversità di Napoli Federico IINaplesItaly
  3. 3.Dipartimento di Medicina Clinica e SperimentaleUniversità di Napoli Federico IINaplesItaly
  4. 4.Dipartimento di Biologia e Patologia Cellulare e MolecolareUniversità di Napoli Federico IINaplesItaly
  5. 5.Consorzio Nazionale Interuniversitario per le Scienze Fisiche della MateriaNaplesItaly

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