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Distribution of Macrolide-Resistance Genes in Staphylococcus aureus Blood-Culture Isolates from Fifteen German University Hospitals

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Abstract

 The purpose of the study was to analyze the distribution of the macrolide-resistance genes in 134 erythromycin-resistant Staphylococcus aureus blood-culture isolates collected at 15 German university hospitals. The most prevalent resistance gene was ermC (68/134; 50.7%), followed by ermA (52/134; 38.8%), ereB (10/134; 7.5%), and mrsA/msrB (4/134; 6%). The least common genes were ermB (3/134; 2.2%) and ereA (1/134; 0.7%). Overall, resistance to erythromycin was predominantly due to the presence of two erm genes, although with different distributions, depending on the methicillin-resistance pattern.

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Authors and Affiliations

  1. Eijkman-Winkler Institute for Clinical Microbiology, Utrecht Medical Center, University of Utrecht, The Netherlands, , , , , , NL

    F.-J. Schmitz & A. C. Fluit

  2. Institute of Medical Microbiology, Westfälische Wilhelms University Münster, Germany, , , , , , DE

    G. Peters & C. von Eiff

  3. Institute for Medical Microbiology and Virology, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, Geb. 22.21, 40225 Düsseldorf, Germany e-mail: schmitfj@uni-duesseldorf.de, , , , , , DE

    J. Petridou & U. Hadding

Authors
  1. F.-J. Schmitz
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  2. J. Petridou
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  3. A. C. Fluit
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  4. U. Hadding
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  5. G. Peters
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  6. C. von Eiff
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Schmitz, FJ., Petridou, J., Fluit, A. et al. Distribution of Macrolide-Resistance Genes in Staphylococcus aureus Blood-Culture Isolates from Fifteen German University Hospitals. EJCMID 19, 385–387 (2000). https://doi.org/10.1007/s100960050500

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  • DOI: https://doi.org/10.1007/s100960050500

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