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Influence of Rheumatoid Factor on the Specificity of a Rapid Immunochromatographic Test for Diagnosing Dengue Infection

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European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

In order to determine the influence of rheumatoid factor in serum specimens on the specificity of an immunochromatographic test for the detection of antibodies against dengue virus, 50 clinical specimens containing rheumatoid factor were evaluated for cross reactivity with a commercially available assay. While specificity for the detection of immunoglobulin (Ig) G antibodies was 100%, the IgM component of the test showed false-positive results in 26% of cases. Thus, it is important to consider interference by rheumatoid factor when using immunochromatographic assays for the detection of specific IgM produced during dengue infection.

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Authors and Affiliations

  1. Department of Infectious Diseases and Tropical Medicine, University of Munich, Leopoldstrasse 5, 80802 Munich, Germany e-mail: jelinek@lrz.uni-muenchen.de, , , , , , DE

    T. Jelinek, S. Pröll & T. Löscher

  2. Rheuma-Einheit der Universität München, Medizinische Poliklinik des Klinikums Innenstadt, Ludwig-Maximilians-University, Munich, Germany, , , , , , DE

    J. Wastlhuber & M. Schattenkirchner

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  1. T. Jelinek
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  2. J. Wastlhuber
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  3. S. Pröll
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  4. M. Schattenkirchner
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  5. T. Löscher
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Jelinek, T., Wastlhuber, J., Pröll, S. et al. Influence of Rheumatoid Factor on the Specificity of a Rapid Immunochromatographic Test for Diagnosing Dengue Infection. EJCMID 19, 555–556 (2000). https://doi.org/10.1007/s100960000318

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  • DOI: https://doi.org/10.1007/s100960000318

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