Data availability
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability
N/A.
References
Terrault NA, Lok ASF, McMahon BJ, Chang KM, Hwang JP, Jonas MM, Brown RS Jr, Bzowej NH, Wong JB (2018) Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology 67:1560–1599. https://doi.org/10.1002/hep.29800
Mallet V, van Bömmel F, Doerig C, Pischke S, Hermine O, Locasciulli A, Cordonnier C, Berg T, Moradpour D, Wedemeyer H, Ljungman P (2016) Management of viral hepatitis in patients with haematological malignancy and in patients undergoing haemopoietic stem cell transplantation: recommendations of the 5th European Conference on Infections in Leukaemia (ECIL-5). Lancet Infect Dis 16:606–617. https://doi.org/10.1016/S1473-3099(16)00118-3
Bacigalupo A, Metafuni E, Amato V, Marquez Algaba E, Pagano L (2020) Reducing infectious complications after allogeneic stem cell transplant. Expert Rev Hematol 13:1235–1251. https://doi.org/10.1080/17474086.2020.1831382
Viganò M, Vener C, Lampertico P, Annaloro C, Pichoud C, Zoulim F, Facchetti F, Poli F, Scalamogna M, Deliliers GL, Colombo M (2011) Risk of hepatitis B surface antigen seroreversion after allogeneic hematopoietic SCT. Bone Marrow Transplant 46:125–131. https://doi.org/10.1038/bmt.2010.70
Hammond SP, Borchelt AM, Ukomadu C, Ho VT, Baden LR, Marty FM (2009) Hepatitis B virus reactivation following allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 15:1049–1059. https://doi.org/10.1016/j.bbmt.2009.05.001
Seto WK, Chan TS, Hwang YY, Wong DK, Fung J, Liu KS, Gill H, Lam YF, Lau EHY, Cheung KS, Lie AKW, Lai CL, Kwong YL, Yuen MF (2017) Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: a prospective study. Hepatology 65:1451–1461. https://doi.org/10.1002/hep.29022
Mikulska M, Nicolini L, Signori A, Rivoli G, Del Bono V, Raiola AM, Di Grazia C, Dominietto A, Varaldo R, Ghiso A, Bacigalupo A, Viscoli C (2014) Hepatitis B reactivation in HBsAg-negative/HBcAb-positive allogeneic haematopoietic stem cell transplant recipients: risk factors and outcome. Clin Microbiol Infect 20:O694-701. https://doi.org/10.1111/1469-0691.12611
Cholongitas E, Haidich AB, Apostolidou-Kiouti F, Chalevas P, Papatheodoridis GV (2018) Hepatitis B virus reactivation in HBsAg-negative, anti-HBc-positive patients receiving immunosuppressive therapy: a systematic review. Ann Gastroenterol 31:480–90. https://doi.org/10.20524/aog.2018.0266
Funding
This paper was supported by Centro di ricerca sulle Cellule staminali emopoietiche e le terapie cellulari-Università Cattolica del Sacro Cuore, Roma, Italy.
Author information
Authors and Affiliations
Contributions
All authors contributed to the study conception and design. Data collection and analysis were performed by Marcello Viscovo, Francesco Santopaolo, Filippo Frioni, and Claudio Pellegrino. Elisabetta Metafuni, Sabrina Giammarco, Simona Sica, Patrizia Chiusolo, and Maurizio Pompili followed the patient. The first draft of the manuscript was written by Marcello Viscovo and Elisabetta Metafuni, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Ethics approval
This study was performed in line with the principles of the Declaration of Helsinki, and ethical approval for this study was obtained from the Ethics Committee of Fondazione Policlinico A. Gemelli IRCCS (prot.0030921/20; July 23, 2020).
Consent to participate
The patient signed informed consent and authorized to publication.
Consent for publication
N/A.
Competing interests
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Viscovo, M., Metafuni, E., Giammarco, S. et al. Late HBV reactivation after hematopoietic stem cell transplantation, despite long-term prophylaxis. Eur J Clin Microbiol Infect Dis 42, 1543–1545 (2023). https://doi.org/10.1007/s10096-023-04685-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10096-023-04685-8