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A rare class A carbapenemase FRI-11 in Enterobacter clinical strain

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Abstract

We found a carbapenem-resistant Enterobacter clinical strain which was susceptible to cefotaxime and ceftazidime. This unusual susceptibility profile promoted the investigation. This strain had blaFRI-11, a rare carbapenemase-encoding gene, on a 93,864-bp plasmid containing two replicons of IncFII(pECLA) and IncFIA(HI1). FRI-11, FRI-2, FRI-3, FRI-4, FRI-6, FRI-7, and FRI-9 belong to the same group of FRI β-lactamases based on the amino acid sequence similarity and their encoding genes are carried by plasmids containing an IncFII(pECLA) replicon. Awareness should be raised towards FRI carbapenemases that are plasmid-encoded and confer an unusual carbapenem-resistant but 3rd-generation-cephalosporin-susceptible resistance profile.

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Fig. 1

Data availability

Complete genome sequences of strain 155105 have been deposited in the GenBank databases under accession numbers CP104976 to CP104979.

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Funding

The work is supported by the National Natural Science Foundation of China (82172309) and grants from the West China Hospital of Sichuan University (1.3.5 project for disciplines of excellence, grant number ZYYC08006 and ZYGD22001).

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Authors and Affiliations

  1. Center of Infectious Diseases, West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, 610041, China

    Shikai Wu, Yanling He & Zhiyong Zong

  2. Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China

    Shikai Wu, Yanling He, Yu Feng & Zhiyong Zong

  3. Center for Pathogen Research, West China Hospital, Sichuan University, Chengdu, China

    Yu Feng & Zhiyong Zong

Authors
  1. Shikai Wu
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  2. Yanling He
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  3. Yu Feng
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  4. Zhiyong Zong
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Contributions

The study conception and design were performed by Zhiyong Zong. Material preparation and data collection and analysis were processed by Shikai Wu and Yanling He. The bioinformatics analysis of the strain genome was carried out by Yu Feng. The first draft of the manuscript was processed by Shikai Wu. The editing and review of the manuscript was completed by Zhiyong Zong. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Zhiyong Zong.

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Not applicable. This study was performed to characterize the bacterial strain only.

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Not applicable. This study was performed to characterize the bacterial strain only.

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The authors declare no competing interests.

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Wu, S., He, Y., Feng, Y. et al. A rare class A carbapenemase FRI-11 in Enterobacter clinical strain. Eur J Clin Microbiol Infect Dis 42, 513–517 (2023). https://doi.org/10.1007/s10096-023-04565-1

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  • DOI: https://doi.org/10.1007/s10096-023-04565-1

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