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Metagenomic next-generation sequencing restores the diagnosis of a rare infectious complication of B cell depletion

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Abstract

A 45-year-old female patient receiving rituximab for B cell non-Hodgkin follicular lymphoma presented unexplained recurrent fever, abdominal discomfort, and pollakiuria. We performed shotgun metagenomic sequencing from peri-kidney collection that identified a co-infection with Mycoplasma hominis and Ureaplasma urealyticum. The patient recovered with sequelae after appropriate antibiotic treatment was given.

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Authors

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All authors directly contributed to the patient management. The first draft of the manuscript was written by MG and L-PZ, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Margaux Garzaro or Maud Salmona.

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Garzaro, M., Zhao, LP., De Castro, N. et al. Metagenomic next-generation sequencing restores the diagnosis of a rare infectious complication of B cell depletion. Eur J Clin Microbiol Infect Dis 41, 1269–1273 (2022). https://doi.org/10.1007/s10096-022-04484-7

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