Data availability
Complete genome sequences of strain 115,011 have been deposited in the GenBank databases under accession numbers CP089953 to CP089958.
References
Chen YT, Chang HY, Lai YC, Pan CC, Tsai SF, Peng HL (2004) Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43. Gene 337:189–198
Russo TA, Olson R, MacDonald U, Beanan J, Davidson BA (2015) Aerobactin, but not yersiniabactin, salmochelin, or enterobactin, enables the growth/survival of hypervirulent (hypermucoviscous) Klebsiella pneumoniae ex vivo and in vivo. Infect Immun 83:3325–3333
Polz MF, Alm EJ, Hanage WP (2013) Horizontal gene transfer and the evolution of bacterial and archaeal population structure. Trends Genet 29:170–175
Yang X, Wai-Chi Chan E, Zhang R, Chen S (2019) A conjugative plasmid that augments virulence in Klebsiella pneumoniae. Nat Microbiol 4:2039–2043
Lin TL, Chuang YP, Huang YT, Hsieh PF, Lin YT, Wang JT (2014) Identification of an immuno-dominant protein from Klebsiella pneumoniae strains causing pyogenic liver abscess: implication in serodiagnosis. BMC Microbiol 14:321
Valenzuela JK, Thomas L, Partridge SR, van der Reijden T, Dijkshoorn L, Iredell J (2007) Horizontal gene transfer in a polyclonal outbreak of carbapenem-resistant Acinetobacter baumannii. J Clin Microbiol 45:453–460
Tsai CJ, Loh JM, Proft T (2016) Galleria mellonella infection models for the study of bacterial diseases and for antimicrobial drug testing. Virulence 7:214–229
Gordo I, Perfeito L, Sousa A (2011) Fitness effects of mutations in bacteria. J Mol Microbiol Biotechnol 21:20–35
Alonso-Del Valle A, Leon-Sampedro R, Rodriguez-Beltran J, DelaFuente J, Hernandez-Garcia M, Ruiz-Garbajosa P, Canton R, Pena-Miller R, San Millan A (2021) Variability of plasmid fitness effects contributes to plasmid persistence in bacterial communities. Nat Commun 12:2653
Dionisio F, Conceição IC, Marques ACR, Fernandes L, Gordo I (2005) The evolution of a conjugative plasmid and its ability to increase bacterial fitness. Biol Let 1:250–252
Funding
This work was supported by the National Natural Science Foundation of China (81861138055) and a grant (project no. ZYYC08006) from West China Hospital of Sichuan University, China.
Author information
Authors and Affiliations
Contributions
The study conception and design was performed by ZZ. Material preparation, data collection and analysis, and the first draft of the manuscript were processed by QZ. The bioinformatics analysis of the strain genome was carried out by YF. The editing and review of the manuscript was completed by ZZ. All authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Ethics approval
Not applicable.
Consent to participate
Informed consent was obtained from the patient in the study.
Consent for publication
The authors affirm that the patient in the study provided informed consent for publication.
Competing interests
The authors declare no competing interests.
Additional information
Publisher's note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Zhao, Q., Feng, Y. & Zong, Z. An integrated IncFIB/IncFII plasmid confers hypervirulence and its fitness cost and stability. Eur J Clin Microbiol Infect Dis 41, 681–684 (2022). https://doi.org/10.1007/s10096-022-04407-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10096-022-04407-6