Abstract
Among 733 pregnant women with HIV followed between 2013 and 2021, only 8 (1.1%) had prior HPV vaccination. One had low-grade squamous intraepithelial lesions [LSIL], and none had HPV type information. Among the 725 non-vaccinated women, 578 (79.7%) had information on cervical cytology. Rate of cytologic abnormalities in this group was 20.6% (0.2% atypical glandular cells of undetermined significance [AGC], 1.7% atypical squamous cells of undetermined significance [ASC-US], 11.1% LSIL, and 7.6% high-grade squamous intraepithelial lesions [HSIL]). Among 56 women with HPV type information, 75.0% carried high risk types, with similar occurrence in women with and without cytologic abnormalities, 30.4% had multiple high-risk types, and 75.9% carried at least one of the types included in the currently recommended 9-valent vaccine.
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The corresponding author had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. All relevant data is detailed in the manuscript.
References
Liu G, Sharma M, Tan N, Barnabas RV (2018) HIV-positive women have higher risk of human papilloma virus infection, precancerous lesions, and cervical cancer. AIDS 32:795–808
Stelzle D, Tanaka LF, Lee KK, Khalil AI, Baussano I, Shah ASV et al (2021) Estimates of the global burden of cervical cancer associated with HIV. Lancet Glob Health 9:e161–e169
Kumakech E, Berggren V, Wabinga H, Lillsunde-Larsson G, Helenius G, Kaliff M et al (2016) Significantly reduced genoprevalence of vaccine-type HPV-16/18 infections among vaccinated compared to non-vaccinated young women 5.5 years after a bivalent HPV-16/18 vaccine (cervarix) pilot project in Uganda. PLoS One 11:e0160099
McClymont E, Lee M, Raboud J, Coutlée F, Walmsley S, Lipsky N et al (2019) The efficacy of the quadrivalent human papillomavirus vaccine in girls and women living with human immunodeficiency virus. Clin Infect Dis 68:788–794
Canvin M, Sinka K, Hughes G, Mesher D (2017) Decline in genital warts diagnoses among young women and young men since the introduction of the bivalent HPV (16/18) vaccination programme in England: an ecological analysis. Sex Transm Infect 93:125–128
Donken R, van Niekerk D, Hamm J, Spinelli JJ, Smith L, Sadarangani M et al (2021) Declining rates of cervical intraepithelial neoplasia in British Columbia, Canada: an ecological analysis on the effects of the school-based human papillomavirus vaccination program. Int J Cancer 49:191–199
Floridia M, Mastroiacovo P, Tamburrini E, Tibaldi C, Todro T, Crepaldi A et al (2013) Birth defects in a national cohort of pregnant women with HIV infection in Italy, 2001-2011. BJOG 120:1466–1475
Clifford GM, Tully S, Franceschi S (2017) Carcinogenicity of human papillomavirus (HPV) types in HIV-positive women: a meta-analysis from HPV infection to cervical cancer. Clin Infect Dis 64:1228–1235
HIV/AIDS Italian Expert Panel (2017) Linee Guida Italiane sull’utilizzo della Terapia Antiretrovirale e la gestione diagnostico-clinica delle persone con infezione da HIV-1 Edizione 2017. Available at: https://www.salute.gov.it/imgs/C_17_pubblicazioni_2696_allegato.pdf. Accessed 6 Aug 2021
Ribassin-Majed L, Pereira M, Magneron C, Levy-Bachelot L, Fagherazzi G, Baldauf JJ et al (2021) Interest of a geostatistical approach to analyze the geographical disparities in human papillomavirus vaccine coverage in France. Rev Epidemiol Sante Publique 69:321–328
Dong L, Nygård M, Hansen BT (2021) Sociodemographic correlates of human papillomavirus vaccine uptake: opportunistic and catch-up vaccination in Norway. Cancers (Basel) 13:3483
Osmani V, Klug SJ (2021) HPV vaccination and the prevention of genital warts and precancerous lesions. Current evidence and evaluation. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 64:590–599
Zheng L, Wu J, Zheng M (2021) Barriers to and facilitators of human papillomavirus vaccination among people aged 9 to 26 years: a systematic review. Sex Transm Dis 48:e255–e262
Bruni L, Diaz M, Castellsagué X, Ferrer E, Bosch FX, de Sanjosé S (2003) Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings. J Infect Dis 202:1789–1799
Acknowledgments
We thank Cosimo Polizzi and Alessandra Mattei of the Istituto Superiore di Sanità in Rome, Italy, for providing technical secretarial for this study. We also thank Ernesto Costabile for providing assistance as documentalist. No compensation was received for these contributions.
The Italian group on surveillance of antiretroviral treatment in pregnancy
Project coordinators: M. Floridia, M. Ravizza, E. Tamburrini.
Participants: M. Ravizza, E. Tamburrini, F. Di Lorenzo, G. Sterrantino, M. Meli, I. Campolmi, F. Vichi, B. Del Pin, R. Marocco, C. Mastroianni, V.S. Mercurio, D. Zanaboni, G. Guaraldi, G. Nardini, C. Stentarelli, B. Beghetto, A.M. Degli Antoni, A. Molinari, N. Bobbio, A. Donisi, A. Ruggieri, M. Piepoli, V. Cerri, G. Zuccotti, V. Giacomet, L. Paradiso, F. Forlanini, E. Longoni, G. Placido, P. Milini, F. Savalli, F. Sabbatini, D. Francisci, C. Papalini, L. Bernini, P. Grossi, L. Rizzi, V. Portelli, G. Maso, M. Bernardon, S. Bussolaro, I. Della Pietà, A. Sorz, A. Meloni, A. Chiodo, M. Dedoni, F. Ortu, P. Piano, I. Bordoni Vicini, K. Luzi, A. Spinillo, M. Roccio, A. Vimercati, D. Calabretti, S. Gigante, B. Guerra, F. Cervi, G. Simonazzi, E. Margarito, M.G. Capretti, C. Marsico, L. Corvaglia, M. Sansone, P. Martinelli, A. Capone, G.M. Maruotti, C. Tibaldi, L. Trentini, G. Masuelli, V. Frisina, V. Savasi, E. Cardellicchio, C. Giaquinto, M. Fiscon, E. Rubino, L. Franceschetti, R. Badolato, M.A. Forleo, B. Tassis, M. Ruggiero, O. Genovese, C. Cafforio, C. Pinnetti, G. Liuzzi, A.M. Casadei, A.F. Cavaliere, M. Cellini, A.M. Marconi, S. Dalzero, M. Ierardi, S.C. Simonetti, N. Alfieri, S. Agrati, C. Polizzi, A. Mattei, M.F. Pirillo, R. Amici, C.M. Galluzzo, S. Donnini, S. Baroncelli, M. Floridia.
Advisory Board: A. Cerioli, M. De Martino, F. Parazzini, E. Tamburrini, S. Vella.
SIGO-HIV Group National Coordinators: P. Martinelli, M. Ravizza.
Funding
This work (currently not funded) was supported in the past by public research grants (ref.: H85E08000200005) from the Italian Medicines Agency (AIFA).
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MF designed the study, drafted, and finalized the manuscript and was responsible for statistical analysis; GM, BT, VMS, MS, AS, LF, GG, CP, SD, AM, AV, GS, ET, and MR substantially contributed to acquisition of data, interpretation of data, and critical revision of the manuscript. All the authors approved the final version to be published.
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Ethics approval was obtained from the Ethics Committee of the I.N.M.I. Lazzaro Spallanzani in Rome. Laboratory and clinical data were collected following the women’s consent, using a patient information sheet that has received approval by the competent Ethics Committee (National Institute for Infectious Diseases L. Spallanzani, Rome, ref. deliberation 578/2001, September 28, 2001).
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Floridia, M., Masuelli, G., Tassis, B. et al. Minimal prevalence of HPV vaccination and common occurrence of high-risk HPV types in pregnant women with HIV: data from a national study in Italy. Eur J Clin Microbiol Infect Dis 41, 505–509 (2022). https://doi.org/10.1007/s10096-021-04393-1
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DOI: https://doi.org/10.1007/s10096-021-04393-1