Abstract
A 26-year-old girl with a longstanding colonization by Pandoraea nosoerga underwent liver-lung transplantation for cystic fibrosis (CF) in 2018. Her brother also suffering from CF was also colonized by P. nosoerga. Despite appropriate perioperative antibiotic therapy, she had post-transplant bacteremic pneumonia caused by extensively drug-resistant P. nosoerga. Drug repurposing was used to optimize treatment options. The cause of post-transplant contamination was studied by comparative whole-genome sequencing including pre- and post-transplant strains and her brother’s strains. Post-transplant contamination appeared to be due to her own pre-transplant strain, emphasizing the urgent need to study and implement effective decontamination protocols before transplantation.
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This work was supported by the French Government under the “Investissements d’avenir” (Investments for the Future) program managed by the Agence Nationale de la Recherche (ANR, fr: National Agency for Research) (reference: Méditerranée Infection 10-IAHU-03). This work was supported by Région Provence-Alpes-Côte d’Azur and European funding FEDER PRIMI.
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Peyclit L., Cassir N., Baron S. A., and Rolain J.-M. designed the study and drafted and revised the manuscript. Peyclit L. and Baron S. A. performed microbiology and genomic analyses. All authors have read and approved the final manuscript.
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Peyclit, L., Baron, S.A., Reynaud-Gaubert, M. et al. Fatal Pandoraea nosoerga infection after combined liver-lung transplantation for cystic fibrosis: a recontamination by the pre-transplantation strain. Eur J Clin Microbiol Infect Dis 40, 2403–2406 (2021). https://doi.org/10.1007/s10096-021-04235-0
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DOI: https://doi.org/10.1007/s10096-021-04235-0