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Temocillin as an alternative treatment for acute bacterial cholangitis: a retrospective microbiology susceptibility-based study of 140 episodes

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Abstract

With rising antibiotic resistance, alternatives to carbapenems are needed for acute cholangitis (AC). Temocillin reaches high biliary concentrations with limited impact on microbiota. We retrospectively included 140 AC episodes and assessed the efficacy of temocillin using microbiology susceptibility testing from blood cultures. Considering all bacteria collected by episode, resistance to temocillin, PIP/TAZ and 3GC occurred in 27/140 (26%), 32 (22.8%) and 31 (22%) episodes, respectively (p = 0.7). After documentation, temocillin could have spared PIP/TAZ or carbapenems in 14/26 and 4/11 episodes. Temocillin may constitute an alternative treatment after microbiological documentation by sparing carbapenems and/or PIP/TAZ, but not as an empirical therapeutic option.

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Acknowledgements

This work was presented in part as a poster at the European Congress of Clinical Microbiology and Infectious Diseases in Amsterdam in April 2019 (Abstract #P0840).

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Authors and Affiliations

  1. Service de Médecine Interne, Hôpital Beaujon, Assistance-Publique Hôpitaux de Paris, 92100, Clichy, Paris, France

    Sylvain Chawki, Aurélien Sokal, Amandine Henry, Bruno Fantin & Victoire de Lastours

  2. Laboratoire de Microbiologie, Hôpital Beaujon, Hôpital Beaujon, Assistance-Publique Hôpitaux de Paris, 92100, Clichy, Paris, France

    Marion Duprilot, Véronique Leflon-Guibout & Marie-Hélène Nicolas-Chanoine

  3. IAME Research Group, UMR 1137, Université de Paris and INSERM, 75018, Paris, France

    Marion Duprilot, Marie-Hélène Nicolas-Chanoine, Bruno Fantin & Victoire de Lastours

Authors
  1. Sylvain Chawki
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  2. Aurélien Sokal
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  3. Marion Duprilot
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  4. Amandine Henry
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  5. Véronique Leflon-Guibout
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  6. Marie-Hélène Nicolas-Chanoine
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  7. Bruno Fantin
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  8. Victoire de Lastours
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Contributions

MHNC, BF and VDL designed the study. SC and AS collected clinical data. MD, AH and VLG performed the microbiology studies. SC, BF and VDL performed the analysis and wrote the paper.

Corresponding author

Correspondence to Victoire de Lastours.

Ethics declarations

Ethical approval

Data collection for the cohort was declared to the French “Commission Nationale Informatique et des Libertés” (CNIL), registration no. 2080377 on 4/4/2017. Under French law, approval by an Institutional Review Board is not mandatory for retrospective monocentric studies.

Consent to participate

All patients were informed of the study. No specific consent was necessary due to the retrospective nature of the work, according to French law.

Consent to publish

All authors have read the paper and gave their consent for publication.

Competing interests

Victoire de Lastours, Véronique Leflon and Bruno Fantin report non-financial support from EUMEDICA (travel expenses). Bruno Fantin reports financial support for participating on a board organised by EUMEDICA on clinical development of temocillin. All other authors declare no conflict of interest concerning this publication.

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Chawki, S., Sokal, A., Duprilot, M. et al. Temocillin as an alternative treatment for acute bacterial cholangitis: a retrospective microbiology susceptibility-based study of 140 episodes. Eur J Clin Microbiol Infect Dis 40, 1773–1777 (2021). https://doi.org/10.1007/s10096-021-04158-w

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  • DOI: https://doi.org/10.1007/s10096-021-04158-w

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