Multi-year prevalence and macrolide resistance of Mycoplasma genitalium in clinical samples from a southern Italian hospital


The use of azithromycin for the treatment of Mycoplasma genitalium infections has led to resistance to macrolides. From July 2014 to July 2020, 7150 samples were analysed for the detection of sexually transmitted infections at the Policlinico of Bari. A total of 67/7150 samples (0.93%) were positive for MG DNA and 47 samples were analysed for the evaluation of six azithromycin resistance-associated mutations. In 5/47 samples, the A2058G mutation was detected (10.63%). Although the cases of positive MG samples and mutations are low in our reality, diagnostic tests to detect azithromycin resistant-associated genes may provide a convenient way to monitor resistance rate.

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Correspondence to Ronga Luigi.

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The study number 5930 was approved by Ethical Committee of Policlinico of Bari (No. 0038512|06|05|2019).

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Angela, A., Raffaele, D.P., Federica, R. et al. Multi-year prevalence and macrolide resistance of Mycoplasma genitalium in clinical samples from a southern Italian hospital. Eur J Clin Microbiol Infect Dis 40, 893–895 (2021).

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  • Mycoplasma genitalium
  • Epidemiology
  • Surveillance
  • Azithromycin resistance
  • Multiplex real-time PCR