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Extensively drug-resistant Acinetobacter baumannii carrying blaOXA-23-like and armA in a hospital after an intervention in the intensive care unit which ended a long-standing endemicity

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Abstract

The aim of the study was to evaluate for a long time the effectiveness of an intervention designed to reduce carbapenem-resistant Acinetobacter baumannii (CRAB) and its impact on colistin usage in the ICU of a tertiary hospital in Spain. The rate of carbapenem resistance declined drastically during the period of study (2015 to 2018), from 93.57 to 74.65%, especially in the ICU. A significant decrease in colistin usage, from 1.16 to 0.39 DOTs, was observed. Forty-nine CRAB isolates recovered nearly 1 year after starting the intervention were characterized. Most of them were recovered from patients admitted in wards other than ICU and were extensively drug-resistant, carried blaOXA-23-like and armA, and belonged to ST218. Implementation of control measures is crucial to CRAB control in ICUs but must be extended to all wards in order to eradicate CRAB from hospitals.

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Authors and Affiliations

  1. Servicio de Microbiología, Hospital Universitario de Cabueñes, 33394, Gijón, Asturias, Spain

    Carlos Rodríguez-Lucas

  2. Departamento de Biología Funcional, Área de Microbiología, Universidad de Oviedo, Oviedo, Spain

    Carlos Rodríguez-Lucas, M. Rosario Rodicio & Xenia Vázquez

  3. Grupo de Microbiología Traslacional, Instituto de Investigación Sanitaria del Principado de Asturias, 33011, Oviedo, Asturias, Spain

    Carlos Rodríguez-Lucas, M. Rosario Rodicio, Xenia Vázquez, Dolores Escudero & Javier Fernández

  4. Servicio de Medicina Intensiva, Hospital Universitario Central de Asturias, 33011, Oviedo, Asturias, Spain

    Dolores Escudero & Brígida Quindós

  5. Servicio de Farmacia Hospitalaria, Hospital Universitario Central de Asturias, 33011, Oviedo, Asturias, Spain

    Miguel Alaguero

  6. Servicio de Microbiología, Hospital Universitario Central de Asturias, Avenida de Roma s/n, 33011, Oviedo, Spain

    Javier Fernández

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  1. Carlos Rodríguez-Lucas
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  2. M. Rosario Rodicio
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  3. Xenia Vázquez
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  4. Dolores Escudero
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  7. Javier Fernández
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Correspondence to Javier Fernández.

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Rodríguez-Lucas, C., Rodicio, M.R., Vázquez, X. et al. Extensively drug-resistant Acinetobacter baumannii carrying blaOXA-23-like and armA in a hospital after an intervention in the intensive care unit which ended a long-standing endemicity. Eur J Clin Microbiol Infect Dis 40, 385–389 (2021). https://doi.org/10.1007/s10096-020-04009-0

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  • DOI: https://doi.org/10.1007/s10096-020-04009-0

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