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A decade after the emergence of Candida auris: what do we know?

European Journal of Clinical Microbiology & Infectious Diseases volume 39, pages 1617–1627 (2020)Cite this article

Abstract

Candida auris is a remarkable emerging pathogen. It has emerged separately, yet simultaneously in different parts of the world, establishing four phylogenetic and geographic distinct clades with a potential fifth clade that was recently reported. C. auris is often perceived as a pathogen in disguise, due to its frequent misidentification and its immune evasion. On the other hand, many of the recovered isolates are multidrug-resistant. In fact, some of these isolates are resistant to the three main antifungal classes: echinocandins, azoles, and polyenes. Moreover, C. auris has the ability to persist and survive on different objects for a long time, aided by different adhering mechanisms including aggregation and biofilm formation, thereby causing outbreaks of invasive infections in hospital settings. However, C. auris ability to maintain its pathogenicity at high temperatures remains among its most unique properties. This is why C. auris represents a challenging threat, and more studies are needed to meet this challenge. This review highlights different characteristics of this emerging yeast with emphasis on its antifungal resistance, its ability to persistent on different surfaces, and its immune evasion capability.

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  1. Department of Microbiology and Immunology, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt

    Amira ElBaradei

  2. Alexandria University Hospital, Alexandria University, Alexandria, Egypt

    Amira ElBaradei

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ElBaradei, A. A decade after the emergence of Candida auris: what do we know?. Eur J Clin Microbiol Infect Dis 39, 1617–1627 (2020). https://doi.org/10.1007/s10096-020-03886-9

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Keywords

  • Candida auris
  • Antifungal resistance
  • ERG11
  • FKS1
  • NETs
  • Biofilm formation