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Epidemiology of Non-Tuberculous Mycobacteria isolated from clinical specimens in Madrid, Spain, from 2013 to 2017

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Abstract

The epidemiology of non-tuberculous mycobacteria (NTM) in Spain is largely unknown because systematic reporting is not compulsory. The aim of our study was to describe the frequency and diversity of NTM species in our region and their distribution according to the source sample, gender, and age of the patients. We performed a multicenter study of all NTM isolated in 24 public hospitals in Madrid from 2013 to 2017. A total of 6.923 mycobacteria were isolated: 4535 (65.5%) NTM, and 2.388 (34.5%) Mycobacterium tuberculosis complex (MTB). Overall, 61 different NTM species were identified. The most frequently isolated species were Mycobacterium avium complex (47.7%), M. lentiflavum (12.2%), M. gordonae (9.2%), M. fortuitum (8.9%), and M. abscessus (3.9%). Whereas MTB cases were stable during the study period, the number of NTM isolates increased considerably from 930 isolates in 2013 to 1012 in 2017; a sharp increase occurred in the last year. The rise in NTM isolates was mostly due to M. lentiflavum, M. kansasii, and M. abscessus mainly isolated from respiratory specimens in patients older than 60. The increase in isolation rate of NTM in our region is consistent with the increasing rates reported worldwide in the last decades. The rise in NTM isolates was mainly attributed to M. lentiflavum but it also should be noted the increasing of species with high pathogenic potential such as M. kansasii and M. abscessus.

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Acknowledgments

Parts of this manuscript were communicated at the 29th ECCMID (Amsterdam, 2019) and the 23rd Congress of SEIMC (Madrid, 2019).

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Authors and Affiliations

  1. Department of Microbiology, Hospital 12 de Octubre, Madrid, Spain

    P López-Roa

  2. Laboratorio Central de Madrid (BRSalud), Madrid, Spain

    E Aznar

  3. Department of Microbiology, Hospital Universitario de Getafe, Getafe, Spain

    J Cacho

  4. Department of Microbiology, Hospital Universitario de Móstoles, Móstoles, Spain

    R Cogollos-Agruña

  5. Department of Microbiology, Hospital Universitario La Princesa, Madrid, Spain

    D Domingo

  6. Department of Microbiology, Hospital Universitario de Fuenlabrada, Fuenlabrada, Spain

    MI García-Arata

  7. Department of Microbiology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain

    R Millán

  8. Department of Microbiology, Hospital Universitario Severo Ochoa, Leganés, Spain

    M Páez

  9. Department of Microbiology, Hospital Clínico San Carlos, Madrid, Spain

    E Perez-Cecilia

  10. Department of Microbiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain

    MJ Ruiz-Serrano

  11. Department of Microbiology, Hospital Central de la Defensa Gómez Ulla, Madrid, Spain

    M Simón

  12. Department of Microbiology, Hospital Universitario Ramón y Cajal, Madrid, Spain

    M Tato

  13. Department of Microbiology, Hospital Universitario La Paz-Carlos III-Cantoblanco, Madrid, Spain

    C Toro

  14. Department of Microbiology, Fundación Hospital de Alcorcón, Alcorcón, Spain

    JF Valverde

  15. Department of Clinical Microbiology, IIS-Fundación Jiménez Díaz, Madrid, Spain

    J Esteban

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  1. P López-Roa
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  2. E Aznar
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  3. J Cacho
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  6. MI García-Arata
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  7. R Millán
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  8. M Páez
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  9. E Perez-Cecilia
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  10. MJ Ruiz-Serrano
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Correspondence to J Esteban.

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López-Roa, P., Aznar, E., Cacho, J. et al. Epidemiology of Non-Tuberculous Mycobacteria isolated from clinical specimens in Madrid, Spain, from 2013 to 2017. Eur J Clin Microbiol Infect Dis 39, 1089–1094 (2020). https://doi.org/10.1007/s10096-020-03826-7

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  • DOI: https://doi.org/10.1007/s10096-020-03826-7

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