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Prevalence and risk factors of post chikungunya rheumatic musculoskeletal disorders: a prospective follow-up study in French Guiana

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Abstract

The estimated seroprevalence in the general population after chikungunya virus (CHIKV) epidemics ranged from 38 to 63%. Despite a low case fatality, subacute and chronic rheumatic forms of CHIKV infection generate significant morbidity and have a socioeconomic impact. The objective of the study was to estimate the prevalence of chronic post-CHIKV rheumatic or musculoskeletal pain (pCHIK-RMSP) at 3 and 6 months after the initial symptoms. An observational study was conducted at Cayenne General Hospital in French Guiana between April 1 and June 30, 2014. All patients seen for CHIKV infection confirmed by RT-PCR were prospectively included. Pregnant women and children under 15 were excluded from the study. All patients were called by phone at 3 and 6 months to enquire about the presence of pCHIK-RMSP. Out of a total of 254 eligible patients, 168 were selected. The mean age was 45.3 years (SD ± 1.4 yo) and the sex ratio (M/F) was 0.75. No death was reported. At 3 months, 40.2% (95% CI 31.1–49.3) of patients (n = 45/112) had pCHIK-RMSP and 31.3% (95% CI 22.2–40.4) of patients (n = 31/99) at 6 months. The median time of end to pain was 2 weeks after the date of onset of signs. The present study provides succinct but informative data about pCHIK-RMSP, which represents the real burden of the disease. There are few studies on that subject in the Amazonian region, but our study shows a lower impact than in the Indian Ocean islands where the population is older.

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Authors and Affiliations

  1. Tropical and Infectious Disease Department Centre hospitalier de Cayenne, Av des flamboyants, 97306, Cayenne, French Guiana, France

    Timothée Bonifay, Jean-François Lienne, Guillaume Vesin, Gaëlle Walter, Félix Djossou & Loïc Epelboin

  2. Centre d’Investigation Clinique Antilles Guyane, Inserm CIC 1424, Centre hospitalier de Cayenne, Av des flamboyants, 97306, Cayenne, French Guiana, France

    Timothée Bonifay & Mathieu Nacher

  3. Department of General Medicine, University of the French West Indies, French West Indies, France

    Timothée Bonifay

  4. Department of Internal Medicine, Centre Hospitalier Andrée Rosemon, F-97300, Cayenne, French Guiana, France

    Cécile Bagoée, Florin Santa & Nathalie Vaserman

Authors
  1. Timothée Bonifay
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  2. Jean-François Lienne
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  10. Loïc Epelboin
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Correspondence to Timothée Bonifay.

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Bonifay, T., Lienne, JF., Bagoée, C. et al. Prevalence and risk factors of post chikungunya rheumatic musculoskeletal disorders: a prospective follow-up study in French Guiana. Eur J Clin Microbiol Infect Dis 37, 2159–2164 (2018). https://doi.org/10.1007/s10096-018-3353-0

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